Abstract:
:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger RNA (mRNA) in subcutaneous adipose tissue (SAT) of psoriasis patients. 17 psoriasis vulgaris patients and 6 non-obese control patients who underwent skin surgery were enrolled in this study. We measured serum leptin levels. SAT samples in psoriasis patients were taken from beneath the lesional psoriatic skin at the time of skin biopsy. Leptin mRNA expression in SAT was measured using quantitative real-time reverse transcription polymerase chain reaction (real-time RT-PCR) amplification. Leptin mRNA expression showed a positive correlation with serum leptin levels and BMI. We classified psoriasis patients into two groups according to BMI: the group of non-obese psoriasis patients (BMI < 25, n = 7), and the group of obese psoriasis patients (BMI ≥ 25, n = 10). PASI score, serum leptin levels and Leptin mRNA expression in SAT were significantly higher in the obese psoriasis patients than in the non-obese psoriasis patients. Leptin mRNA expression in SAT was correlated with circulating levels of leptin, the severity of psoriasis, and obesity in psoriasis patients. Serum leptin levels and leptin mRNA expression levels in SAT of non-obese psoriasis patients were not significantly different from those of non-obese controls. The altered secretion of leptin by SAT may be related to the severity of psoriasis.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Mitsuyama S,Abe F,Kimura M,Yoshida M,Higuchi Tdoi
10.1007/s00403-015-1581-zsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
539-44issue
6eissn
0340-3696issn
1432-069Xjournal_volume
307pub_type
杂志文章abstract::This study was designed to investigate the proliferative activity of the buccal mucosa in healthy adult persons with regard to individual age. Punch biopsy specimens were taken from the buccal mucosa of 19 individuals (10 females, 9 males) ranging in age from 24 to 80 years, and were then examined autoradiographically...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00407881
更新日期:1979-06-25 00:00:00
abstract::Total osmotic pressure does not differ significantly in suction blister fluid or in serum of healthy persons from blister fluid, suction blister fluid or serum of patients with dermatitis herpetiformis, bullous contact dermatitis and pemphigus vulgaris. The average values reach about 293 mOsmol/kg. This results from d...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The effects of acidic and basic fibroblast growth factors (aFGF and bFGF, respectively) on proliferation and differentiation of cultured hair apparatus cells were examined using bovine pituitary extract (BPE)-free media. The importance of FGFs as growth factors in BPE was also examined. Both FGFs and BPE stimulated ce...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371577
更新日期:1994-01-01 00:00:00
abstract::Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1517-z
更新日期:2014-12-01 00:00:00
abstract::Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
doi:10.1007/s00403-014-1525-z
更新日期:2015-03-01 00:00:00
abstract::Human skin epithelial-like cells (NCTC strain 2544) were grown in NCTC 135 medium. Neuraminidase and hyaluronidase were added to the growth medium. Cells were incubated 96 h at 36 degrees C. Growth rate and viscosity of cell suspensions were measured after forming single cells mechanically (mopping). With addition of ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455372
更新日期:1978-02-15 00:00:00
abstract::Previous studies showed an association between various dermatological diseases and epicardial fat thickness (EFT). However, EFT, which has been accepted as a cardiometabolic risk factor in recent years, has not been studied in the context of hidradenitis suppurativa (HS). Therefore, we aimed to determine whether EFT i...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-02032-6
更新日期:2020-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050263
更新日期:1997-11-01 00:00:00
abstract::This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1734-3
更新日期:2017-07-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1752-1
更新日期:2017-09-01 00:00:00
abstract::Using the sebum-absorbent tape technique, we have disclosed five different patterns of follicular sebum excretion rate (SER). These are the infantile, pubertal, acne, adult and aging patterns, distinguished by different densities of active sebaceous follicles, by distinct levels of follicular SER and by the relative s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585931
更新日期:1987-01-01 00:00:00
abstract::Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1530-2
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Human VAT-1 (hVAT-1) is a homologue of the synaptic vesicle membrane protein of Torpedo californica. Its coding gene is located near the BRCA1 locus and thus hVAT-1 may be linked to an inherited predisposition to breast and ovary cancer. However, the hVAT-1 protein expression pattern in normal epith...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-003-0421-8
更新日期:2003-09-01 00:00:00
abstract::The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1250-4
更新日期:2012-11-01 00:00:00
abstract::The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1487-1
更新日期:2014-10-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/BF00638233
更新日期:1992-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-018-1826-8
更新日期:2018-07-01 00:00:00
abstract::The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed b...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02165-z
更新日期:2020-11-22 00:00:00
abstract::In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章,meta分析
doi:10.1007/s00403-017-1736-1
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abstract::No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-018-1882-0
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journal_title:Archives of dermatological research
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更新日期:2020-05-08 00:00:00
abstract::The aim of this study was to explore dermatologists' practices and attitudes related to educating and counseling their adolescent patients about indoor tanning. An online survey was carried out with a convenience sample of 100 dermatologists. Findings indicated that the majority of the dermatologists are actively enga...
journal_title:Archives of dermatological research
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更新日期:2020-11-01 00:00:00
abstract::Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional sur...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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abstract::The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1719-2
更新日期:2017-04-01 00:00:00
abstract::Thrombin has recently been shown not only to exert procoagulant activities, but also to induce mitogenic responses of different cell types involved in wound healing via binding to and cleavage of the thrombin receptor. In order to further explore these aspects of thrombin function, human keratinocytes (HaCaT cell line...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed in some papers, the mechanism of BCC pathogenesis is not fully understood. To the best of our knowledge, VEGF gene polymorphisms have ...
journal_title:Archives of dermatological research
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更新日期:2014-08-01 00:00:00