Abstract:
:This study was designed to investigate the proliferative activity of the buccal mucosa in healthy adult persons with regard to individual age. Punch biopsy specimens were taken from the buccal mucosa of 19 individuals (10 females, 9 males) ranging in age from 24 to 80 years, and were then examined autoradiographically, applying nuclear 3H-thymidine labelling in vitro under oxygen pressure of 2.2 atm. The mean total labelling index in the progenitor compartment amounted to 26.0 +/- 2.6% including 6.2 +/- 2.0% labelled basal nuclei and 19.8 +/- 2.6% labelled suprabasal nuclei. Related to 1,000 mu surface length, the mean number of basal cells runs up to 270.7 +/- 38.6 and the total nuclear labelling index to 70.9 +/- 10.4. This high rate of S phase nuclei, exceeding that of the epidermis several times, depends on the ample progenitor compartment as well as on the basal epithelium length which, as compared to the epithelium surface length, was shown to be extended by a mean proportion of 1.75. None of the autoradiographic results obtained in the present study revealed an age dependency of the buccal mucosa proliferative activity. The magnitude of the proliferative pool constitutes the matrix of the high renewal rate of the healthy buccal mucosa and provides a steady state of superficial cell loss and basal cell regeneration, that was proved, at least in the normal mucosa, to continue until senile age.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Maidhof R,Hornstein OPdoi
10.1007/BF00407881subject
Has Abstractpub_date
1979-06-25 00:00:00pages
165-72issue
2eissn
0340-3696issn
1432-069Xjournal_volume
265pub_type
杂志文章abstract::Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00408223
更新日期:1981-01-01 00:00:00
abstract::The immigration of circulating T cells into specific tissues is directed by the interaction between adhesion molecules on lymphocyte subpopulations and their ligands on vascular endothelium. Of these, endothelial leucocyte adhesion molecule (ELAM-1), weakly expressed in normal human skin (NHS), seems to be the counter...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372006
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abstract::The dependence of epithelial spread on human serum in culture has been studied. Using measured pieces of mouse ear skin epithelial outgrowth about floating explants (epiboly) and from adherent explants was studied. Where compared directly the two systems show similar results. Because of its ease of quantitation, the a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417274
更新日期:1979-02-23 00:00:00
abstract::Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1689-9
更新日期:2016-12-01 00:00:00
abstract::1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00446949
更新日期:1978-12-01 00:00:00
abstract::Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1984-01-01 00:00:00
abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-010-1095-7
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abstract::Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...
journal_title:Archives of dermatological research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00403-006-0654-4
更新日期:2006-06-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0979-x
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journal_title:Archives of dermatological research
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abstract::Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050449
更新日期:1999-10-01 00:00:00
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journal_title:Archives of dermatological research
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doi:10.1007/s00403-008-0868-8
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abstract::Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00505639
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abstract::This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...
journal_title:Archives of dermatological research
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abstract::Hand warts were studied in 160 butchers. Clinical and histological studies were performed in 190 warts and virological studies in 165 warts from 104 butchers. Since we found almost perfect correlation between the histological pattern and the type of infecting virus, it was possible to evaluate the virus types in a fur...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585924
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412496
更新日期:1985-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505260
更新日期:1996-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-1009-8
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abstract::IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
abstract::The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00505640
更新日期:1990-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1582-y
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abstract::Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed cons...
journal_title:Archives of dermatological research
pub_type: 杂志文章,meta分析
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00