Abstract：
:Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induced by mite allergens. Pooled sera from the conventional NC/Nga mice, and AD model animals, were incubated with varying concentrations of the control and KC-850U-pretreated allergens extracted from mite. The incubated mixtures were transferred to wells coated with intact allergens and subjected to ELISA to measure the amounts of immunoglobulin E (IgE) bound to the wells. Kinetic analysis revealed that exposure of mite extracts to plasma cluster ions destructed about 95% of the epitopes of the allergens. The specific pathogen-free and conventional mice were housed in rooms equipped with either KC-850U or a standard air cleaner and observed their dermal symptom for 2 weeks. Dermatological examination revealed the AD symptom of the conventional mice housed in a room equipped with an air cleaner. In contrast, the symptoms which became apparent during the experiments were suppressed remarkably exposing mice to plasma cluster ions. These observations suggested that plasma cluster ions generated by KC-850U destroyed the epitopes of mite allergens and suppressed the symptoms of AD in the mice.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Hiramoto K,Orita K,Yamate Y,Sato EF,Okano H,Nishikawa K,Inoue Mdoi
10.1007/s00403-010-1095-7subject
Has Abstractpub_date
2011-07-01 00:00:00pages
367-70issue
5eissn
0340-3696issn
1432-069Xjournal_volume
303pub_type
杂志文章abstract：:Nickel, cobalt and chromium are metals very often implicated in allergic contact dermatitis. In vivo, keratinocytes, which are the first target cells, can be directly activated to participate in the local reaction, especially through the expression of the membrane antigen ICAM-1, a ligand of the leucocyte antigen LFA-...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371573
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abstract：:Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...
journal_title：Archives of dermatological research
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abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
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doi：10.1007/s00403-015-1581-z
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abstract：:The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...
journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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doi：10.1007/BF00404286
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00429985
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00413357
更新日期：1984-01-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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abstract：:Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1 (control) were untreated and unexposed; Group 2 were untreated and exposed to ...
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更新日期：2020-05-08 00:00:00
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journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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abstract：:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...
journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
abstract：:Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1685-0
更新日期：2016-11-01 00:00:00
