Abstract：
:T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were not significantly different to those observed in normal subjects. In 15 patients with active disease, immunoregulatory mechanisms were functionally studied using an assay measuring the amount of total IgG synthesized in vitro. Peripheral-blood leukocytes were separated into T- and B-cell fractions, and cultured in various combinations. In ten experiments, prior to culturing with B cells, the T cells were irradiated to remove their suppressor function. No statistically significant differences were observed in the amount of total IgG synthesized by B cells obtained from patients and normal subjects when they were cultured with untreated T cells or irradiated T cells obtained from patients or normal controls. These results indicate that, in patients with bullous pemphigoid, there is no loss of suppressor-cell function or increased helper-cell function as assessed by measuring the total IgG synthesized. Therefore, the immunoregulatory defect, if present, is a highly specific one and can only be studied using antigen-specific assays.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Ahmed ARdoi
10.1007/BF00509086subject
Has Abstractpub_date
1985-01-01 00:00:00pages
307-12issue
4eissn
0340-3696issn
1432-069Xjournal_volume
277pub_type
杂志文章abstract：:Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1340-y
更新日期：2013-08-01 00:00:00
abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050398
更新日期：1999-04-01 00:00:00
abstract：:A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412923
更新日期：1986-01-01 00:00:00
abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1863-3
更新日期：2018-11-01 00:00:00
abstract：:This study determines if the anatomic region affected percutaneous absorption in the rhesus monkey, an animal model with some relevance to man. Percutaneous absorption of testosterone (13.3 microgram/cm2) from the ventral forearm was 8.8 +/- 2.5%. Absorption from the chest was slightly less (5.3 +/- 0.6%) while that f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403844
更新日期：1980-01-01 00:00:00
abstract：:To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
abstract：:Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-011-1161-9
更新日期：2011-12-01 00:00:00
abstract：:In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373422
更新日期：1995-01-01 00:00:00
abstract：:Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505639
更新日期：1990-01-01 00:00:00
abstract：:The aim of this study was to screen the antioxidant, anti-hyaluronidase, and anti-elastase activity of the lyophilized juice of Cucumis sativus fruit (CSLJ). The CSLJ was subjected to DPPH and superoxide radical scavenging assay in reference to butylated hydroxytoluene. The hyaluronidase and elastase inhibitory assay ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1103-y
更新日期：2011-05-01 00:00:00
abstract：:Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0628-y
更新日期：2006-03-01 00:00:00
abstract：:We report the clinical features of 62 consecutive patients with lichen planus observed in 18 months. The largest number of cases occurred between 50 and 70 years of age. Thirty-four patients had lichen planus only. In the remainder, lichen planus was associated with chronic liver diseases (16 cases), immune-related di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00412560
更新日期：1984-01-01 00:00:00
abstract：:The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-005-0607-3
更新日期：2005-12-01 00:00:00
abstract：:Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050444
更新日期：1999-09-01 00:00:00
abstract：:To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1079-7
更新日期：2011-04-01 00:00:00
abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02507101
更新日期：1996-06-01 00:00:00
abstract：:To have as further insight into the localizations of immune deposits in the skin the reversed passive and the passive Arthus reactions were carried out in the foot-pads skin of guinea-pigs using horseradish peroxidase as antigen. The transient localizations of immune deposits in the papillary dermis and in the epiderm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404457
更新日期：1980-01-01 00:00:00
abstract：:Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated exp...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-018-1826-8
更新日期：2018-07-01 00:00:00
abstract：:The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate. We studied 187 women with alopecia, which we graded I, II, or III, according to Ludwig's classification, and 21 healthy control women. All participants were subjected to...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000184
更新日期：2000-12-01 00:00:00
abstract：:A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404624
更新日期：1984-01-01 00:00:00
abstract：:In dermatophytosis, there is exocytosis of polymorphonuclear leukocytes (PMNs) toward the fungus-laden horny layer. To analyze this mechanism, we studied in vitro leukotactic properties of epidermal extracts prepared from lesions of experimental Trichophyton mentagrophytes infection in guinea pigs as well as fungus-de...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409248
更新日期：1982-01-01 00:00:00
abstract：:The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404455
更新日期：1980-01-01 00:00:00
abstract：:The fetal development of Merkel cells-neuroendocrine cells of the skin - has been a matter of debate for a long time. Recent results have helped to confirm their intraepidermal development in humans. Simple epithelial cytokeratins (CK) nos. 8, 18, 19 and 20 are well established markers at the light microscopic level. ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505222
更新日期：1996-04-01 00:00:00
abstract：:Scleroderma is a chronic fibrosing disease, in which an early inflammatory reaction precedes the fibrotic response. Systematic analysis of the pathways involved in the development of the disease together with information derived from novel animal models have helped to better understand the mechanisms that trigger and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-007-0756-7
更新日期：2007-06-01 00:00:00
abstract：:This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed tha...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00440602
更新日期：1988-01-01 00:00:00
abstract：:Marie Unna Hereditary Hypotrichosis 1 (MUHH1; OMIM 146550), a rare monogenic condition characterized by the development of sparse, twisted hair or complete hair loss, is the consequence of mutations located in the hairless (HR) gene. We have identified a 68-year-old Hungarian woman affected by alopecia universalis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1244-2
更新日期：2012-10-01 00:00:00
abstract：:Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosan-activated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin a produced an increased...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409454
更新日期：1981-01-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1517-z
更新日期：2014-12-01 00:00:00
