Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia.

Abstract:

:Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia. Here, we analyse the androgen-induced dermal papilla secreted factors on stimulating catagen entry in hair follicles and the molecular cross-talk between AR and Wnt/β-catenin signaling with a brief mention on alternative treatment strategy targeting Wnt/β-catenin signaling for promoting hair growth.

journal_name

Arch Dermatol Res

authors

Premanand A,Reena Rajkumari B

doi

10.1007/s00403-018-1826-8

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

391-399

issue

5

eissn

0340-3696

issn

1432-069X

pii

10.1007/s00403-018-1826-8

journal_volume

310

pub_type

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