Abstract:
:Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia. Here, we analyse the androgen-induced dermal papilla secreted factors on stimulating catagen entry in hair follicles and the molecular cross-talk between AR and Wnt/β-catenin signaling with a brief mention on alternative treatment strategy targeting Wnt/β-catenin signaling for promoting hair growth.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Premanand A,Reena Rajkumari Bdoi
10.1007/s00403-018-1826-8subject
Has Abstractpub_date
2018-07-01 00:00:00pages
391-399issue
5eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-018-1826-8journal_volume
310pub_type
杂志文章,评审abstract::Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00511060
更新日期:1984-01-01 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-014-1480-8
更新日期:2014-12-01 00:00:00
abstract::This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030000176
更新日期:2000-11-01 00:00:00
abstract::Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin de...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412738
更新日期:1990-01-01 00:00:00
abstract::The treatment of epidermolysis bullosa acquisita (EBA) is difficult and often disappointing. We report on the successful treatment of two EBA patients with colchicine. The drug was administered orally at an initial dose of 2 mg/day. After 2 weeks of therapy a dramatic improvement was observed. Most of the cutaneous an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00375841
更新日期:1994-01-01 00:00:00
abstract::The adenylate cyclase system of an established human trichilemmoma cell line was investigated. Stimulators of human epidermal adenylate cyclase system, epinephrine, histamine, adenosine, and prostaglandin E increased cyclic AMP levels of the trichilemmoma cells. The effects of epinephrine, histamine, and adenosine wer...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00413285
更新日期:1987-01-01 00:00:00
abstract::Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412927
更新日期:1986-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0623-3
更新日期:2006-02-01 00:00:00
abstract::Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403786
更新日期:1981-01-01 00:00:00
abstract::Epidermolytic hyperkeratosis (EH) is a genetic disorder of keratins associated with epidermal differentiation. Affected individuals carry gene mutations for conserved sequences of keratins K1 or K10. The structural alterations of tonofilaments in EH seem to be a direct consequence of the keratin gene mutations. EH epi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01105793
更新日期:1995-01-01 00:00:00
abstract::HaCaT keratinocytes differ from normal human epidermal keratinocytes (HEK) by constitutive expression of differentiation markers which are normally suppressed by vitamin A. In search of an explanation for this discrepancy we compared the vitamin A content, the expression of retinoid-binding proteins, and the vitamin A...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050419
更新日期:1999-06-01 00:00:00
abstract::Myotonic muscular dystrophy (MMD) is caused by an abnormal function of RNA-binding proteins (RBP) resulting in DNA spliceopathy. A case of a patient, with MMD multiple basal and squamous cell carcinomas and dysplastic nevi, is described. The association between MMD and non-melanoma skin cancer has been reported before...
journal_title:Archives of dermatological research
pub_type: 新闻
doi:10.1007/s00403-009-0997-8
更新日期:2010-04-01 00:00:00
abstract::Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0542-3
更新日期:2005-04-01 00:00:00
abstract::Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...
journal_title:Archives of dermatological research
pub_type: 信件
doi:10.1007/s00403-004-0508-x
更新日期:2004-10-01 00:00:00
abstract::Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00412560
更新日期:1984-01-01 00:00:00
abstract::This study was designed to investigate the proliferative activity of the buccal mucosa in healthy adult persons with regard to individual age. Punch biopsy specimens were taken from the buccal mucosa of 19 individuals (10 females, 9 males) ranging in age from 24 to 80 years, and were then examined autoradiographically...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00407881
更新日期:1979-06-25 00:00:00
abstract::Primary hyperhidrosis is a condition characterized by excessive sweating. The estimated prevalence is between 0.6 and 4.4%, and it can have economic, psychological, and social consequences for affected individuals. Family and genetic studies have suggested a genetic component in the inheritance of the disease. In this...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-019-01966-1
更新日期:2019-12-01 00:00:00
abstract::Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01982-1
更新日期:2020-03-01 00:00:00
abstract::Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1340-y
更新日期:2013-08-01 00:00:00
abstract::T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509086
更新日期:1985-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00403-004-0465-4
更新日期:2004-06-01 00:00:00
abstract::Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0645-5
更新日期:2006-07-01 00:00:00
abstract::The fetal development of Merkel cells-neuroendocrine cells of the skin - has been a matter of debate for a long time. Recent results have helped to confirm their intraepidermal development in humans. Simple epithelial cytokeratins (CK) nos. 8, 18, 19 and 20 are well established markers at the light microscopic level. ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505222
更新日期:1996-04-01 00:00:00
abstract::Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0357-4
更新日期:2003-01-01 00:00:00
abstract::We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice. Metronidazole and tinidazole ointments (1) suppressed the late-phase reaction (LPR) ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0381-4
更新日期:2003-03-01 00:00:00
abstract::CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1863-3
更新日期:2018-11-01 00:00:00
abstract::Linoleic acid is required for the formation and maintenance of the epidermal barrier, but most of the current in vitro keratinocyte culture systems are linoleic acid-deficient. The aim of the present study was to examine the efficiency of linoleic acid uptake in human keratinocyte cultures grown under submerged and ai...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050430
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abstract::The pathomorphological and pathophysiological reactions of the first skincycle of the mutant (Ng) were histologically investigated. 1. During the hair growth disturbances as the result of imperfect keratinisation changes of the morphology and function of different skin areas could be observed. 2. The developments of a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455574
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abstract::Primary cultures of guinea pig ear keratinocytes were treated with vitamin A acid at plating, or at 14 h or 14 days after plating. The intracellular content of the cyclic nucleotides cAMP and cGMP was determined by radioimmunoassay at intervals during a period of 50 h after treatment. When added at plating, vitamin A ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00416918
更新日期:1980-01-01 00:00:00
abstract::Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional sur...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02118-6
更新日期:2020-08-09 00:00:00