Abstract：
:A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain and trypsin was detected in this band. Using sodium-dodecyl-sulphate PAGE, the molecular mass of the inhibitor was estimated to be 2,200 daltons.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Takiuchi I,Takagi H,Goi H,Kawamura M,Higuchi Ddoi
10.1007/BF00412923subject
Has Abstractpub_date
1986-01-01 00:00:00pages
194-8issue
3eissn
0340-3696issn
1432-069Xjournal_volume
278pub_type
杂志文章abstract：:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1530-2
更新日期：2015-05-01 00:00:00
abstract：:This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only sl...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694617
更新日期：1979-10-01 00:00:00
abstract：:Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0868-8
更新日期：2008-10-01 00:00:00
abstract：:As the main nitrogen source in Malassezia furfur, tryptophan induces the formation of fluorochromes and pigments, which make the yeast less sensitive to UV light. To detect a chemical UV filter, M. furfur (CBS 1878) was incubated at 30 degrees C for 14 days on a pigment-inducing medium and agar extracts were purified ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0294-2
更新日期：2002-05-01 00:00:00
abstract：:An increase in phosphodiesterase 4 (PDE4) in blood mononuclear white cells of patients with atopic dermatitis (AD) has been described. This and other skin disorders worsen during stress, during which there are increased circulating levels of adrenaline and glucocorticoids. The aim of this study was to analyse the effe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0313-3
更新日期：2002-07-01 00:00:00
abstract：:Patients with certain inflammatory skin diseases have multiple risk factors for venous thromboembolism (VTE). The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis is associated with VTE in US adults. Data were analyzed from the 2002-2012 Natio...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02099-6
更新日期：2020-07-08 00:00:00
abstract：:We report the clinical features of 62 consecutive patients with lichen planus observed in 18 months. The largest number of cases occurred between 50 and 70 years of age. Thirty-four patients had lichen planus only. In the remainder, lichen planus was associated with chronic liver diseases (16 cases), immune-related di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene en...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1762-z
更新日期：2017-10-01 00:00:00
abstract：:In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen...
journal_title：Archives of dermatological research
pub_type： 历史文章,杂志文章
doi：10.1007/s00403-002-0328-9
更新日期：2002-08-01 00:00:00
abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373353
更新日期：1993-01-01 00:00:00
abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050398
更新日期：1999-04-01 00:00:00
abstract：:To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
abstract：:Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417145
更新日期：1981-01-01 00:00:00
abstract：:Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585921
更新日期：1987-01-01 00:00:00
abstract：:Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505639
更新日期：1990-01-01 00:00:00
abstract：:Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-011-1166-4
更新日期：2011-11-01 00:00:00
abstract：:Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/pl00007450
更新日期：1998-07-01 00:00:00
abstract：:Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050449
更新日期：1999-10-01 00:00:00
abstract：:The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1719-2
更新日期：2017-04-01 00:00:00
abstract：:A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404624
更新日期：1984-01-01 00:00:00
abstract：:Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0747-8
更新日期：2007-06-01 00:00:00
abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0683-z
更新日期：2006-09-01 00:00:00
abstract：:Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0572-x
更新日期：2005-07-01 00:00:00
abstract：:Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412622
更新日期：1987-01-01 00:00:00
abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1654-7
更新日期：2016-08-01 00:00:00
abstract：:Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509062
更新日期：1982-01-01 00:00:00
abstract：:A 61-year old woman developed a tumourous nodule in her left leg. Fifteen years ago a similar tumour had been removed in the same localization. Histological examination performed on biopsy material showed bundles of predominantly fusiform tumour cells with nuclear pleomorphism and many mitotic figures. Electron micros...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00446437
更新日期：1978-11-10 00:00:00
abstract：:Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0628-y
更新日期：2006-03-01 00:00:00
abstract：:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00426614
更新日期：1988-01-01 00:00:00
abstract：:A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00402624
更新日期：1990-01-01 00:00:00
