Abstract:
:Patients with certain inflammatory skin diseases have multiple risk factors for venous thromboembolism (VTE). The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis is associated with VTE in US adults. Data were analyzed from the 2002-2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N = 72,512,581 adults, including 1,389,292 with VTE). In multivariable logistic regression models including age, sex, insurance, household income and race/ethnicity, hospitalization for AD (adjusted odds ratio [95% confidence intervals] 1.22 [1.17-1.27]), pemphigus (1.96 [1.68-2.28]) and pemphigoid (1.64 [1.47-1.83]) was associated with VTE. These associations remained significant in virtually all patient subsets, including males and females, different age groups and those with and without long-term corticosteroid use. In particular, AD, pemphigus and pemphigoid were each associated with DVT and PE. VTE was associated with increased inpatient length of stay, cost of care and mortality across all the inflammatory skin diseases. HS and psoriasis were not consistently associated with VTE. AD, pemphigus and pemphigoid and some subsets of patients with HS were associated with higher odds of hospitalization for VTE. Patients with these inflammatory skin diseases may benefit from increased screening and prevention of VTE.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Shaheen MS,Silverberg JIdoi
10.1007/s00403-020-02099-6subject
Has Abstractpub_date
2020-07-08 00:00:00eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-020-02099-6pub_type
杂志文章abstract::Classic Refsum disease (RD) is a rare, autosomal recessively-inherited disorder of peroxisome metabolism due to a defect in the initial step in the alpha oxidation of phytanic acid (PA), a C16 saturated fatty acid with four methyl side groups, which accumulates in plasma and lipid enriched tissues (please see van den ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1478-2
更新日期:2014-10-01 00:00:00
abstract::Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1654-7
更新日期:2016-08-01 00:00:00
abstract::An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424270
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abstract::Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050444
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abstract::Besides its role in small-cell carcinoma of the lung, elevated serum levels of neuron-specific enolase (NSE) have recently been reported to be associated with autoimmune rheumatic disorders such as systemic sclerosis. Serum NSE seems to correlate with disease activity as well as Rodnan skin score. The aim of the study...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0495-y
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abstract::The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1681-4
更新日期:2016-11-01 00:00:00
abstract::Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing glycerol in relatively high amounts, preventing drawing conclusions from direct effects. In this study, acute che...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-1021-z
更新日期:2010-08-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed in some papers, the mechanism of BCC pathogenesis is not fully understood. To the best of our knowledge, VEGF gene polymorphisms have ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1471-9
更新日期:2014-08-01 00:00:00
abstract::Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1347-4
更新日期:2013-08-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
doi:10.1007/s004030050231
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abstract::The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00426583
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abstract::Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1340-y
更新日期:2013-08-01 00:00:00
abstract::Staphylococcus aureus is a common wound-infecting organism which can interact with cells via the extracellular matrix protein fibronectin (FN). The aim of this study was to determine the effect of the FN-binding protein (FnBP) of S. aureus on the behaviour of a human skin keratinocytes cell line (UP). FN-coated plates...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0515-y
更新日期:2004-11-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-013-1381-2
更新日期:2013-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1126-z
更新日期:2011-04-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00373422
更新日期:1995-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00493466
更新日期:1990-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00694628
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abstract::To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455295
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412923
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1332-y
更新日期:2013-07-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371800
更新日期:1994-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1530-2
更新日期:2015-05-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
abstract::In the study described here we investigated the possibility of an association between the aggressiveness of melanoma and multidrug resistance phenotype by analyzing the expression and activity of P-glycoprotein (Pgp) in two genetically related transplantable hamster melanomas--a melanotic (Ma) and an amelanotic (Ab) f...
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pub_type: 杂志文章
doi:10.1007/s004030000146
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