Differential expression of matrix metalloproteinases and their physiological inhibitors in acute murine skin wounds.

abstract：:We previously showed that the homeodomain protein HOXC13 is involved in the expression control of the early human hair keratin genes hHa5 and hHa2, which contain specific HOXC13 binding sites in their proximal promoters. Hox specificity is generally thought to be enhanced by the interaction with members of the TALE su...

journal_title：Archives of dermatological research

authors： Jave-Suárez LF,Schweizer J

更新日期：2006-02-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these ...

journal_title：Archives of dermatological research

authors： Mersmann M,Dworschak J,Ebermann K,Komorowski L,Schlumberger W,Stöcker W,Zillikens D,Probst C,Schmidt E

更新日期：2016-01-01 00:00:00

abstract：:Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...

journal_title：Archives of dermatological research

authors： Magina S,Esteves-Pinto C,Moura E,Serrão MP,Moura D,Petrosino S,Di Marzo V,Vieira-Coelho MA

更新日期：2011-04-01 00:00:00

abstract：:For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...

journal_title：Archives of dermatological research

authors： Nickoloff BJ

更新日期：1992-01-01 00:00:00

abstract：:Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional sur...

journal_title：Archives of dermatological research

authors： Lee KC,Lee I,Okhovat JP,Ko J,Powers JG,Ellis DL,Cheeley J,Garibyan L

更新日期：2020-08-09 00:00:00

abstract：:Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...

journal_title：Archives of dermatological research

authors： Metzler G,Schaumburg-Lever G,Liebig K

更新日期：1990-01-01 00:00:00

abstract：:We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...

journal_title：Archives of dermatological research

authors： Kraemer KH,Robinson RC,Tarone RE,Protic-Sabljic M,Gelboin HV

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Data on how patients with a history of skin cancer apply sunscreen are lacking. OBJECTIVE:To characterize (1) gender differences in sunscreen application technique (quantity used, anatomic site coverage, and time allocated) and (2) differences in sunscreen application to unaffected skin versus previous skin...

journal_title：Archives of dermatological research

authors： Dang J,Reserva J,Tung-Hahn E,Vasicek B,Krol C,Adams W,Tung R,Alam M

更新日期：2020-12-01 00:00:00

abstract：:The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris. It has been hypothesized that calcipotriol counteracts glucocorticoid-induced skin atrophy which is associated with changes in the extracellular matrix (ECM). To elucidate the combined effects ...

journal_title：Archives of dermatological research

authors： Norsgaard H,Kurdykowski S,Descargues P,Gonzalez T,Marstrand T,Dünstl G,Røpke M

更新日期：2014-10-01 00:00:00

abstract：:This study was designed to investigate the proliferative activity of the buccal mucosa in healthy adult persons with regard to individual age. Punch biopsy specimens were taken from the buccal mucosa of 19 individuals (10 females, 9 males) ranging in age from 24 to 80 years, and were then examined autoradiographically...

journal_title：Archives of dermatological research

authors： Maidhof R,Hornstein OP

更新日期：1979-06-25 00:00:00

abstract：:Thrombin has recently been shown not only to exert procoagulant activities, but also to induce mitogenic responses of different cell types involved in wound healing via binding to and cleavage of the thrombin receptor. In order to further explore these aspects of thrombin function, human keratinocytes (HaCaT cell line...

journal_title：Archives of dermatological research

authors： Algermissen B,Sitzmann J,Nürnberg W,Laubscher JC,Henz BM,Bauer F

更新日期：2000-10-01 00:00:00

abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...

journal_title：Archives of dermatological research

authors： Zesch A,Schaefer H,Stüttgen G

更新日期：1979-11-01 00:00:00

abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...

journal_title：Archives of dermatological research

authors： Callewaert C,Hutapea P,Van de Wiele T,Boon N

更新日期：2014-10-01 00:00:00

abstract：:Abnormal dermal deposition of elastic fibers is the earliest and most striking effect of prolonged sun exposure (solar elastosis). The hyperplastic fibers are usually ascribed to ultraviolet (UV) rays. Nonetheless, other portions of the solar spectrum may play contributing roles. Heat, for example, enhances experiment...

journal_title：Archives of dermatological research

authors： Kligman LH

更新日期：1982-01-01 00:00:00

abstract：:As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...

journal_title：Archives of dermatological research

authors： Schneider BV,Maie O

更新日期：1985-01-01 00:00:00

abstract：:The dependence of epithelial spread on human serum in culture has been studied. Using measured pieces of mouse ear skin epithelial outgrowth about floating explants (epiboly) and from adherent explants was studied. Where compared directly the two systems show similar results. Because of its ease of quantitation, the a...

journal_title：Archives of dermatological research

authors： Stenn KS,Dvoretzky I

更新日期：1979-02-23 00:00:00

abstract：:The exposure of naked unprotected skin to solar radiation may result in numerous acute and chronic undesirable effects. Evidence suggests that silymarin, a standardized extract from Silybum marianum (L.) Gaertn. seeds, and its major component silybin suppress UVB-induced skin damage. Here, we aimed to investigate the ...

journal_title：Archives of dermatological research

authors： Rajnochová Svobodová A,Gabrielová E,Ulrichová J,Zálešák B,Biedermann D,Vostálová J

更新日期：2019-08-01 00:00:00

abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...

journal_title：Archives of dermatological research

authors： Goulart IM,Goulart LR

更新日期：2008-07-01 00:00:00

abstract：:The pathomorphological and pathophysiological reactions of the first skincycle of the mutant (Ng) were histologically investigated. 1. During the hair growth disturbances as the result of imperfect keratinisation changes of the morphology and function of different skin areas could be observed. 2. The developments of a...

journal_title：Archives of dermatological research

authors： Franz E,Bosse K,Kreutzer E

更新日期：1978-06-29 00:00:00

abstract：:Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...

journal_title：Archives of dermatological research

authors： Walsh A,Chapman SJ

更新日期：1991-01-01 00:00:00

abstract：:Staphylococcus aureus is a common wound-infecting organism which can interact with cells via the extracellular matrix protein fibronectin (FN). The aim of this study was to determine the effect of the FN-binding protein (FnBP) of S. aureus on the behaviour of a human skin keratinocytes cell line (UP). FN-coated plates...

journal_title：Archives of dermatological research

authors： Kintarak S,Nair SP,Speight PM,Whawell SA

更新日期：2004-11-01 00:00:00

abstract：:HaCaT keratinocytes differ from normal human epidermal keratinocytes (HEK) by constitutive expression of differentiation markers which are normally suppressed by vitamin A. In search of an explanation for this discrepancy we compared the vitamin A content, the expression of retinoid-binding proteins, and the vitamin A...

journal_title：Archives of dermatological research

authors： Törmä H,Rollman O,Vahlquist A

更新日期：1999-06-01 00:00:00

abstract：:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous ...

journal_title：Archives of dermatological research

authors： Salem SA,Abu-Zeid RM,Nada OH

更新日期：2013-03-01 00:00:00

abstract：:Recently, medium-dose UVA1 phototherapy (50 J/cm2) has been introduced as an effective treatment for severe atopic dermatitis (AD). In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement in skin status in patients with AD, biopsy specimens from ten patients before an...

journal_title：Archives of dermatological research

authors： Breuckmann F,Pieck C,Kreuter A,Bacharach-Buhles M,Mannherz HG,Altmeyer P,von Kobyletzki G

更新日期：2001-04-01 00:00:00

abstract：:Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...

journal_title：Archives of dermatological research

authors： Emami A,Halim AS,Salahshourifar I,Yussof SJ,Khoo TL,Kannan TP

更新日期：2012-09-01 00:00:00

abstract：:Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of...

journal_title：Archives of dermatological research

authors： Weidenthaler B,Hausser I,Anton-Lamprecht I

更新日期：1993-01-01 00:00:00

abstract：:Painting of 3,3',4',5-tetrachlorosalicylanilide (TCSA) plus ultraviolet A (UVA) irradiation to the same site induces contact photosensitivity (CPS), but at the same time results in death of the photohapten-modified cells. Using an in vitro immune lymph node cell (LNC) proliferation system, we investigated the mechanis...

journal_title：Archives of dermatological research

authors： Tokura Y,Satoh T,Yamada M,Takigawa M

更新日期：1991-01-01 00:00:00

abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....

journal_title：Archives of dermatological research

authors： Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LB

更新日期：2006-03-01 00:00:00

abstract：:Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...

journal_title：Archives of dermatological research

authors： Komine M,Watabe Y,Shimaoka S,Sato F,Kake K,Nishina H,Ohtsuki M,Nakagawa H,Tamaki K

更新日期：1999-09-01 00:00:00

abstract：:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...

journal_title：Archives of dermatological research

authors： Tsushima H,Higashiyama K,Mine H

更新日期：1996-07-01 00:00:00