Abstract:
:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It had 100 amino acid residues and molecular mass of 11 406 Da, and its N-terminus was blocked. The amino acid sequence of the inhibitor demonstrated high similarity with that of the family 1 group, especially bovine thymus-derived cystatin. Thus, in summary, bovine hoof contains a cystatin-type cysteine proteinase inhibitor, presumably a family 1 cystatin.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Tsushima H,Higashiyama K,Mine Hdoi
10.1007/BF02505240subject
Has Abstractpub_date
1996-07-01 00:00:00pages
484-8issue
8eissn
0340-3696issn
1432-069Xjournal_volume
288pub_type
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