Abstract:
:The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone with and without skin delipidization. It was postulated that the natural skin barrier was reestablished by the metabolic cutaneous lipid regeneration concomitant with the absorption of the fatty ingredients from the cream.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Bucks DA,Maibach HI,Menczel E,Wester RCdoi
10.1007/BF00416669subject
Has Abstractpub_date
1983-01-01 00:00:00pages
242-5issue
4eissn
0340-3696issn
1432-069Xjournal_volume
275pub_type
杂志文章abstract::Six cases of dermatofibrosarcoma protuberans were studied ultrastructurally. Biopsy material from all six cases as well as cell cultures derived from four cases were examined. In all cases, the tumor cells in vivo and in vitro were related to fibroblasts. The two cases with histiocytoid features and a small spiral pat...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00409221
更新日期:1985-01-01 00:00:00
abstract::Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0569-5
更新日期:2005-08-01 00:00:00
abstract::Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585921
更新日期:1987-01-01 00:00:00
abstract::Recent evidence indicates that the biologically active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], has an effect on the regulation of the immune response. We investigated whether topical treatment of mice with 1 alpha,25(OH)2D3 influences the contact hypersensitivity (CHS) response to...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412982
更新日期:1989-01-01 00:00:00
abstract::Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1685-0
更新日期:2016-11-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-013-1381-2
更新日期:2013-09-01 00:00:00
abstract::The composition of the aerobic and anaerobic bacterial skin flora was investigated quantitatively and qualitatively in 25 patients with seborrheic eczema (SE) and in 35 healthy persons. In SE patients, the geometric mean count for propionibacteria in the pilosebaceous ducts of the forehead was reduced to a statistical...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404292
更新日期:1980-01-01 00:00:00
abstract::Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioim...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01106107
更新日期:1991-01-01 00:00:00
abstract::Nowadays, there is a great attention to the plasma applications in medicine. Not only does cold atmospheric pressure plasma provide a therapeutic opportunity to control redox-based processes, it is also an innovative method in rejuvenation. Given the current interest in new methods of rejuvenation, we aimed to introdu...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-02020-w
更新日期:2020-07-01 00:00:00
abstract::Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1828-6
更新日期:2018-07-01 00:00:00
abstract::For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/BF00638233
更新日期:1992-01-01 00:00:00
abstract::Total osmotic pressure does not differ significantly in suction blister fluid or in serum of healthy persons from blister fluid, suction blister fluid or serum of patients with dermatitis herpetiformis, bullous contact dermatitis and pemphigus vulgaris. The average values reach about 293 mOsmol/kg. This results from d...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Photodynamic therapy (PDT) in dermatology has been proven to be a successful noninvasive therapeutic modality for treating skin cancer. To facilitate its clinical introduction, the development of topical photosensitizers is necessary to avoid generalized, cutaneous photosensitivity. Therefore the penetration of synthe...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050168
更新日期:1997-02-01 00:00:00
abstract::The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1595-6
更新日期:2015-11-01 00:00:00
abstract::The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
doi:10.1007/s004030050231
更新日期:1997-08-01 00:00:00
abstract::Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1126-z
更新日期:2011-04-01 00:00:00
abstract::The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050474
更新日期:2000-04-01 00:00:00
abstract::Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-018-1823-y
更新日期:2018-07-01 00:00:00
abstract::To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1079-7
更新日期:2011-04-01 00:00:00
abstract::Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...
journal_title:Archives of dermatological research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00403-006-0654-4
更新日期:2006-06-01 00:00:00
abstract::The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly divided into the treatment group (n = 56) and the control group (n = 44). The treatment group was medicated with calcium gluconate (10 mg/ time, 1 time/day), vitamin D3 (i...
journal_title:Archives of dermatological research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00403-019-01967-0
更新日期:2019-12-01 00:00:00
abstract::Histochemical findings of primary and metastatic amelanotic melanomas were shown by the formaldehyde-induced fluorescence method (Falck and Hillarp). All or some of the amelanotic melanoma cells were discovered to emit green specific fluorescence. Results of the determination of 5-S-cysteinyldopa and DOPA in amelanoti...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417207
更新日期:1983-01-01 00:00:00
abstract::Serotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functiona...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0909-3
更新日期:2009-07-01 00:00:00
abstract::The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system's response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1760-1
更新日期:2017-09-01 00:00:00
abstract::Keratin specificity analyses of eight anti-keratin antibodies (34 beta B4 (K1), 35 beta H11 (K8), Ks 13.1 (K13), Ks 19.1 (K19), PKK1, LP34 (CK1), KL1 and AE1) using keratin protein derived from normal thigh epidermis, normal parotid gland and a human squamous cell carcinoma cell line (HSC-5) were performed, and compar...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00370816
更新日期:1993-01-01 00:00:00
abstract::Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00403-012-1297-2
更新日期:2013-04-01 00:00:00
abstract::Wound infections with multi-drug resistant bacteria increase morbidity and mortality and have considerable socioeconomic impact. They can lead to impaired wound healing, resulting in rising treatment costs. The aim of this study was to investigate an ex vivo human wound infection model. Human full-thickness skin from ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-1009-8
更新日期:2010-07-01 00:00:00
abstract::The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0967-1
更新日期:2009-10-01 00:00:00
abstract::A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404624
更新日期:1984-01-01 00:00:00
abstract::The effect of theophylline, an inhibitor of phosphodiesterase, on tyrosine (Tyr) transport across cell membrane was studied using cultured B-16 mouse melanoma cells. 1.5 mM Theophylline in culture medium increased Tyr uptake velocity in linear fashion up to 36 h, after which it reached a plateau at which the cells sho...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00414014
更新日期:1984-01-01 00:00:00