Percutaneous penetration of hydrocortisone in humans following skin delipidization by 1:1:1 trichloroethane.

Abstract:

:The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone with and without skin delipidization. It was postulated that the natural skin barrier was reestablished by the metabolic cutaneous lipid regeneration concomitant with the absorption of the fatty ingredients from the cream.

journal_name

Arch Dermatol Res

authors

Bucks DA,Maibach HI,Menczel E,Wester RC

doi

10.1007/BF00416669

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

242-5

issue

4

eissn

0340-3696

issn

1432-069X

journal_volume

275

pub_type

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