Abstract：
:As the main nitrogen source in Malassezia furfur, tryptophan induces the formation of fluorochromes and pigments, which make the yeast less sensitive to UV light. To detect a chemical UV filter, M. furfur (CBS 1878) was incubated at 30 degrees C for 14 days on a pigment-inducing medium and agar extracts were purified by column chromatography, preparative TLC and HPLC. Structural analysis of the pure metabolites was performed by mass spectroscopy and NMR. A yellow compound eluting from the column with 64% acetonitrile was found to be a potential UV filter because of its broad UV absorption (lambda(max) 389, 315, 289, 212 nm). It was an indole derivative (C(20)H(13)N(3)O; pityriacitrin) which had recently been shown to be a potent UV filter in bacteria. Its UV protective properties were confirmed in a yeast model and also in humans. Pityriasis versicolor induced by Malassezia yeasts is characterized by depigmented skin areas showing reduced melanin synthesis but no increased UV sensitivity. This UV protection might be explained by the presence of pityriacitrin which is produced by M. furfur.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Mayser P,Schäfer U,Krämer HJ,Irlinger B,Steglich Wdoi
10.1007/s00403-002-0294-2keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
131-4issue
3eissn
0340-3696issn
1432-069Xjournal_volume
294pub_type
杂志文章abstract：:The effects of acidic and basic fibroblast growth factors (aFGF and bFGF, respectively) on proliferation and differentiation of cultured hair apparatus cells were examined using bovine pituitary extract (BPE)-free media. The importance of FGFs as growth factors in BPE was also examined. Both FGFs and BPE stimulated ce...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371577
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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doi：10.1007/BF00417528
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 信件
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journal_title：Archives of dermatological research
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doi：10.1007/BF00413357
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01112911
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585931
更新日期：1987-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00374074
更新日期：1995-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0884-8
更新日期：2008-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00403-002-0313-3
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...
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pub_type： 杂志文章
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