Abstract：
:Up to now, bicomponent keratohyalin has only been described for rat epithelium and human intraepidermal sweat ducts and fetal nail organ cells. In normal human interductal epidermis, the keratohyalin appears homogeneous, osmiophilic and stellate in shape. Under pathological conditions, bicomponent keratohyalin has been observed in different palmoplantar keratoses and has therefore been thought to be associated with abnormal keratosis. We studied the keratinization process in normal human plantar epidermis, in which keratohyalin was found to exhibit several morphological differences as compared to that seen in non-ridged skin. The most striking feature was seen in upper granular cells, where the keratohyalin granules consisted of two components of differing electron density. The electron-dense component formed the main part of the composite granule and was found in the cytoplasm of lower and upper granular cells. The less-electron-dense component was attached to the main component and appeared in the cytoplasm of upper granular cells, forming the convex contact zone. No intranuclear osmiophilic inclusions were present. The respective electron densities of the two keratohyalin components of ridged skin were obviously different to that of the bicomponent keratohyalin granules seen in the epidermal sweat-duct cells of the same specimen. These findings indicate the presence of at least two different types of keratohyalin proteins in normal human ridged skin. They can be distinguished at the electron-microscope level and differ from the keratohyalin of human non-ridged skin as well as from bicomponent keratohyalin granules derived from human epidermal sweat-duct cells or from rat epithelium.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Kastl I,Anton-Lamprecht Idoi
10.1007/BF00493461subject
Has Abstractpub_date
1990-01-01 00:00:00pages
71-5issue
2eissn
0340-3696issn
1432-069Xjournal_volume
282pub_type
杂志文章abstract：:In the present study, attempts were made to clarify the role of an elastase-like enzyme in Arthus reaction by using rabbit-peritoneal polymorphonuclear leukocytes (PMNs). It was first confirmed that the injection of large amounts of PMNs with antibody can increase tissue damage in reversed Arthus reaction. The five va...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00413357
更新日期：1984-01-01 00:00:00
abstract：:To elucidate the interaction between melanoma and its matrix, we cultured B16 murine melanoma cells on and in type I collagen gel and evaluated specified functions of melanoma cells; tyrosinase activity and melanin-synthesizing capacity. Proliferation of cells cultured in these environments was markedly suppressed com...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371647
更新日期：1990-01-01 00:00:00
abstract：:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...
journal_title：Archives of dermatological research
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doi：10.1007/s00403-016-1681-4
更新日期：2016-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455372
更新日期：1978-02-15 00:00:00
abstract：:The cellular origin of Merkel cell carcinoma (MCC) is controversial. We previously hypothesized that MCC originates from hair follicle stem cells or Merkel cell (MC) progenitors residing within the hair follicle bulge. Examination of three cases of combined MCC led to the unexpected discovery that numerous keratin 20 ...
journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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journal_title：Archives of dermatological research
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更新日期：2014-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455295
更新日期：1978-05-31 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404316
更新日期：1985-01-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417277
更新日期：1979-02-23 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417712
更新日期：1988-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694624
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00440602
更新日期：1988-01-01 00:00:00
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-007-0809-y
更新日期：2008-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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更新日期：2001-09-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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doi：10.1007/s004030100239
更新日期：2001-07-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：2014-08-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：1997-07-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：1998-07-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：1996-04-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：1994-01-01 00:00:00
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