Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma.

abstract：:The aim of this study was to investigate the presence and density of the nerve fibre-marker protein gene product 9.5 (PGP 9.5), with immunohistochemistry, in skin from patients with hidradenitis suppurativa (HS). Punch biopsies were obtained from 16 patients; 10 with involvement of the groin and six with axillary dise...

journal_title：Archives of dermatological research

authors： Sartorius K,Emtestam L,Lapins J,Johansson O

更新日期：2010-08-01 00:00:00

abstract：:Keratin specificity analyses of eight anti-keratin antibodies (34 beta B4 (K1), 35 beta H11 (K8), Ks 13.1 (K13), Ks 19.1 (K19), PKK1, LP34 (CK1), KL1 and AE1) using keratin protein derived from normal thigh epidermis, normal parotid gland and a human squamous cell carcinoma cell line (HSC-5) were performed, and compar...

journal_title：Archives of dermatological research

authors： Ansai SI,Katagata Y,Yoshikawa KI,Hozumi Y,Aso K

更新日期：1993-01-01 00:00:00

abstract：:Langerhans cells appear to be critical for IgE-mediated allergen capture and presentation in human atopic dermatitis. The present study sought to determine whether epidermal (i.e Langerhans cells) and dermal dendritic cells in the skin of dogs with atopic dermatitis are hyperplastic and expressed surface IgE. Frozen s...

journal_title：Archives of dermatological research

authors： Olivry T,Moore PF,Affolter VK,Naydan DK

更新日期：1996-09-01 00:00:00

abstract：:In dermatophytosis, there is exocytosis of polymorphonuclear leukocytes (PMNs) toward the fungus-laden horny layer. To analyze this mechanism, we studied in vitro leukotactic properties of epidermal extracts prepared from lesions of experimental Trichophyton mentagrophytes infection in guinea pigs as well as fungus-de...

journal_title：Archives of dermatological research

authors： Tagami H,Natsume N,Aoshima T,Inoue F,Suehisa S,Yamada M

更新日期：1982-01-01 00:00:00

abstract：:Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...

journal_title：Archives of dermatological research

authors： Kubo M,Zhao Y,Moriguchi T

更新日期：2012-11-01 00:00:00

abstract：:The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...

journal_title：Archives of dermatological research

authors： Paquet P,Jacob E,Damas P,Pirson J,Piérard G

更新日期：2005-12-01 00:00:00

abstract：:This study was designed to investigate the proliferative activity of the buccal mucosa in healthy adult persons with regard to individual age. Punch biopsy specimens were taken from the buccal mucosa of 19 individuals (10 females, 9 males) ranging in age from 24 to 80 years, and were then examined autoradiographically...

journal_title：Archives of dermatological research

authors： Maidhof R,Hornstein OP

更新日期：1979-06-25 00:00:00

abstract：:This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated ...

journal_title：Archives of dermatological research

authors： Zerbinati N,D'Este E,Parodi PC,Calligaro A

更新日期：2017-07-01 00:00:00

abstract：:Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...

journal_title：Archives of dermatological research

authors： Metzler G,Schaumburg-Lever G,Liebig K

更新日期：1990-01-01 00:00:00

abstract：:In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...

journal_title：Archives of dermatological research

authors： Eberle J,Garbe C,Orfanos CE

更新日期：1995-01-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these ...

journal_title：Archives of dermatological research

authors： Mersmann M,Dworschak J,Ebermann K,Komorowski L,Schlumberger W,Stöcker W,Zillikens D,Probst C,Schmidt E

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to explore dermatologists' practices and attitudes related to educating and counseling their adolescent patients about indoor tanning. An online survey was carried out with a convenience sample of 100 dermatologists. Findings indicated that the majority of the dermatologists are actively enga...

journal_title：Archives of dermatological research

authors： Nahar VK,Wilkerson AH,Mayer JE,Gromley Z,Berry D,Nahar L,Brodell RT

更新日期：2020-11-01 00:00:00

abstract：:When determined in vitro, the SPF of certain commercial sunscreen products can be lower than the SPF indicated on the label. The study of the composition of this type of product enabled us to note that the majority contained substances reputed to have anti-inflammatory properties. This effect is shown by inhibiting th...

journal_title：Archives of dermatological research

authors： Couteau C,Chauvet C,Paparis E,Coiffard LJ

更新日期：2012-12-01 00:00:00

abstract：:Although cell death by apoptosis has been recognized as an important control mechanism in the maintenance of tissue homeostasis and in the elimination of cells with damaged DNA, information on the induction and characteristics of apoptosis in keratinocytes is rather scarce. Apoptotic mechanisms may play an important r...

journal_title：Archives of dermatological research

authors： Henseleit U,Rosenbach T,Kolde G

更新日期：1996-10-01 00:00:00

abstract：:It has been reported that artificial restoration of barrier function by a water vapor-impermeable membrane after tape stripping induces barrier abrogation in hairless mice, impeding rather than enhancing barrier recovery. To address this issue, we examined the morphologic changes in the epidermis after tape stripping ...

journal_title：Archives of dermatological research

authors： Jiang S,Koo SW,Lee SH

更新日期：1998-03-01 00:00:00

abstract：:The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...

journal_title：Archives of dermatological research

authors： Lavrijsen AP,Tieben LM,Ponec M,van der Schroeff JG,van Muijen GN

更新日期：1989-01-01 00:00:00

abstract：:Using the sebum-absorbent tape technique, we have disclosed five different patterns of follicular sebum excretion rate (SER). These are the infantile, pubertal, acne, adult and aging patterns, distinguished by different densities of active sebaceous follicles, by distinct levels of follicular SER and by the relative s...

journal_title：Archives of dermatological research

authors： Piérard GE,Piérard-Franchimont C,Lê T,Lapière C

更新日期：1987-01-01 00:00:00

abstract：:Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...

journal_title：Archives of dermatological research

authors： Ramot Y,Marzani B,Pinto D,Sorbellini E,Rinaldi F

更新日期：2018-07-01 00:00:00

abstract：:HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...

journal_title：Archives of dermatological research

authors： Eggert J,Zachariae H,Svejgaard E,Svejgaard A,Kissmeyer-Nielsen F

更新日期：1982-01-01 00:00:00

abstract：:Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. B. Grassi were invited to participate in the study (n = 395). Infor...

journal_title：Archives of dermatological research

authors： Fortes C,Mastroeni S,Mannooranparampil TJ,Di Lallo D

更新日期：2019-07-01 00:00:00

abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...

journal_title：Archives of dermatological research

authors： Takeda K,Hatamochi A,Arakawa M,Ueki H

更新日期：1993-01-01 00:00:00

abstract：:In the present study, attempts were made to clarify the role of an elastase-like enzyme in Arthus reaction by using rabbit-peritoneal polymorphonuclear leukocytes (PMNs). It was first confirmed that the injection of large amounts of PMNs with antibody can increase tissue damage in reversed Arthus reaction. The five va...

journal_title：Archives of dermatological research

authors： Hamanaka K,Toki N,Tsushima H,Takasugi S

更新日期：1984-01-01 00:00:00

abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...

journal_title：Archives of dermatological research

authors： Meguro S,Arai Y,Masukawa Y,Uie K,Tokimitsu I

更新日期：2000-09-01 00:00:00

abstract：:Recent studies on eosinophilic fasciitis have lead to this investigation of eosinophilia in progressive systemic sclerosis and localized scleroderma. Eosinophilia (eosinophilic count greater than 300/cmm) was found in ten of 63 progressive systemic sclerosis patients (15.8%) and in two of nine localized scleroderma ca...

journal_title：Archives of dermatological research

authors： Giordano M,Ara M,Valentini G,Chianese U,Bencivenga T

更新日期：1981-01-01 00:00:00

abstract：:The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system's response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with...

journal_title：Archives of dermatological research

authors： Ottas A,Fishman D,Okas TL,Kingo K,Soomets U

更新日期：2017-09-01 00:00:00

abstract：:Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6...

journal_title：Archives of dermatological research

authors： Barlow RJ,Macdonald DM,Black AK,Greaves MW

更新日期：1995-01-01 00:00:00

abstract：:To elucidate the interaction between melanoma and its matrix, we cultured B16 murine melanoma cells on and in type I collagen gel and evaluated specified functions of melanoma cells; tyrosinase activity and melanin-synthesizing capacity. Proliferation of cells cultured in these environments was markedly suppressed com...

journal_title：Archives of dermatological research

authors： Kono T,Furukawa M,Tanii T,Mizuno N,Taniguchi S,Ishii M,Hamada T

更新日期：1990-01-01 00:00:00

abstract：:A procedure measuring the ornithine decarboxylase (ODC) activity and polyamine formation of intact neonatal mouse epidermal cells in culture has been developed and tested. Basal cells prepared from neonatal mouse epidermis were plated on round 15-mm Lux coverslips, placed in Costar 24 well culture clusters and grown a...

journal_title：Archives of dermatological research

authors： Roseeuw DI,Duell EA,Marcelo CL

更新日期：1982-01-01 00:00:00

abstract：:The histological and ultrastructural effects following 3 weeks' topical treatment with two agents (all-trans retinoic acid and a new synthetic retinoid-like substance, CD271) were evaluated on the epidermis and the epithelial wall of the pseudocomedones in rhino mouse skin. The comedolytic effects of these drugs were ...

journal_title：Archives of dermatological research

authors： Bernerd F,Ortonne JP,Bouclier M,Chatelus A,Hensby C

更新日期：1991-01-01 00:00:00

abstract：:A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...

journal_title：Archives of dermatological research

authors： Neittaanmäki H,Karjalainen S,Fräki JE,Kiistala U

更新日期：1984-01-01 00:00:00