Abstract:
:Genetic differences are involved in the development of lupus erythematosus (LE). Skin lesions are influenced by environmental triggers such as ultraviolet light, temperature, and chemical stresses, and the patterns of skin lesion are variable in cutaneous LE such as systemic LE (SLE), chronic discoid LE (CDLE), subacute cutaneous LE (SCLE), and LE tumidus (LET). Although there are a few conflicting reports, many Japanese dermatologists feel there are photosensitivity differences in lupus erythematosus between Asian and Caucasian subjects with SCLE and LET. HLA studies in Japanese subjects revealed that HLA-DRB1*1501 association was with both CDLE and SLE. The association between HLA-Cw6 and CDLE was first reported in Japanese population, and a HLA-A33-B44-DRB1*1302 haplotype showed a positive association in CDLE. However, these results are not compatible with those from Caucasian subjects. There are no significant associations among HLA studies, photosensitivity, and anti-Ro/SS-A antibodies in Japanese CLE patients. Photosensitivity will be a key factor to dissolve multi-factorial complexes of LE etiopathogenesis. Our present understanding is that an axis of photosensitivity, anti-Ro/SS-A antibodies and apoptosis via TNF are the best (markers) to verify the contribution of genetics in SCLE, LET, and other CLEs. The incidence and photosensitivity of SCLE and LET are much lower in Japanese than in Caucasian subjects. However, this discrepancy may open the window for investigating CLE pathogenesis through global collaborations. For this purpose and goal, a new and more conventional method should be developed for the examination of so-called photosensitivity.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Furukawa F,Muto Mdoi
10.1007/s00403-008-0897-3subject
Has Abstractpub_date
2009-01-01 00:00:00pages
111-5issue
1eissn
0340-3696issn
1432-069Xjournal_volume
301pub_type
杂志文章,评审abstract::Nickel, cobalt and chromium are metals very often implicated in allergic contact dermatitis. In vivo, keratinocytes, which are the first target cells, can be directly activated to participate in the local reaction, especially through the expression of the membrane antigen ICAM-1, a ligand of the leucocyte antigen LFA-...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371573
更新日期:1994-01-01 00:00:00
abstract::An aromatic retinoid (Ro 10-9359) in 13-cis retinoic acid (Ro 4-3780) were fed by gastric tube to 170 male adult Syrian hamsters daily for 30 days. A low dose of 1 or 2 mg/kg and a high dose of 20 mg/kg body weight were selected. The effects of both retinoids on the sebaceous glands were assessed planimetrically (15 g...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404284
更新日期:1980-01-01 00:00:00
abstract::Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585921
更新日期:1987-01-01 00:00:00
abstract::Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/pl00007450
更新日期:1998-07-01 00:00:00
abstract::Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372034
更新日期:1992-01-01 00:00:00
abstract::The immigration of circulating T cells into specific tissues is directed by the interaction between adhesion molecules on lymphocyte subpopulations and their ligands on vascular endothelium. Of these, endothelial leucocyte adhesion molecule (ELAM-1), weakly expressed in normal human skin (NHS), seems to be the counter...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372006
更新日期:1993-01-01 00:00:00
abstract::The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed b...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02165-z
更新日期:2020-11-22 00:00:00
abstract::Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505821
更新日期:1996-03-01 00:00:00
abstract::The established mouse epidermis-derived cell line HEL/30 was incubated in the presence of 3H arachidonic acid (AA) for 1 h. After medium removal, cells were reincubated with fresh medium in the presence or absence of the calcium ionophore A23187 and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The AA me...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00429984
更新日期:1988-01-01 00:00:00
abstract::In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00373422
更新日期:1995-01-01 00:00:00
abstract::In the present study the action of various cytokines as regulators of human melanocyte growth and differentiation was examined in vitro. Primary melanocyte cultures were obtained in complete medium free of 12-O-tetradecanoylphorbol-13-acetate or serum. First passage melanocytes were treated with various concentrations...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01105076
更新日期:1995-01-01 00:00:00
abstract::The rhino mouse comedolytic model and the hairless mouse photoaging model are established animal models for screening the in vivo activity of retinoids. However, the expression of the retinoic acid receptors (RARs) and cellular retinoic acid-binding proteins (CRABPs), known to regulate retinoid activity, is not comple...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00373433
更新日期:1995-01-01 00:00:00
abstract::This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed tha...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00440602
更新日期:1988-01-01 00:00:00
abstract::Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404352
更新日期:1986-01-01 00:00:00
abstract::Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00407745
更新日期:1986-01-01 00:00:00
abstract::A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371642
更新日期:1990-01-01 00:00:00
abstract::Although cell death by apoptosis has been recognized as an important control mechanism in the maintenance of tissue homeostasis and in the elimination of cells with damaged DNA, information on the induction and characteristics of apoptosis in keratinocytes is rather scarce. Apoptotic mechanisms may play an important r...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505277
更新日期:1996-10-01 00:00:00
abstract::One of the primary events in the pathogenesis of acne vulgaris is abnormal follicular keratinization. Since oral isotretinoin therapy reduces follicular hyperkeratinization in acne, our study has been designed to determine whether epidermal lipid composition of the epithelium of sebaceous follicles is affected by isot...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417712
更新日期:1988-01-01 00:00:00
abstract::To have as further insight into the localizations of immune deposits in the skin the reversed passive and the passive Arthus reactions were carried out in the foot-pads skin of guinea-pigs using horseradish peroxidase as antigen. The transient localizations of immune deposits in the papillary dermis and in the epiderm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404457
更新日期:1980-01-01 00:00:00
abstract::Marie Unna Hereditary Hypotrichosis 1 (MUHH1; OMIM 146550), a rare monogenic condition characterized by the development of sparse, twisted hair or complete hair loss, is the consequence of mutations located in the hairless (HR) gene. We have identified a 68-year-old Hungarian woman affected by alopecia universalis and...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1244-2
更新日期:2012-10-01 00:00:00
abstract::A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412923
更新日期:1986-01-01 00:00:00
abstract::Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1126-z
更新日期:2011-04-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-013-1381-2
更新日期:2013-09-01 00:00:00
abstract::Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0645-5
更新日期:2006-07-01 00:00:00
abstract::Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large number of genes involved in immune responses, including cytokines and ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0342-y
更新日期:2002-12-01 00:00:00
abstract::Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-008-0889-3
更新日期:2009-01-01 00:00:00
abstract::We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0863-0
更新日期:2008-07-01 00:00:00
abstract::The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509237
更新日期:1985-01-01 00:00:00
abstract::Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509062
更新日期:1982-01-01 00:00:00
abstract::Langerhans cells appear to be critical for IgE-mediated allergen capture and presentation in human atopic dermatitis. The present study sought to determine whether epidermal (i.e Langerhans cells) and dermal dendritic cells in the skin of dogs with atopic dermatitis are hyperplastic and expressed surface IgE. Frozen s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505260
更新日期:1996-09-01 00:00:00