Abstract：
:Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of abnormalities of keratin filament aggregation. In bullous congenital ichthyosiform erythroderma Brocq and epidermolytic palmoplantar keratoderma Voerner suprabasal clumping of keratin filaments prevents the normal spreading of keratohyalin between keratin filaments. Keratohyalin granules, either isolated or attached to clumped keratins, were specifically labelled by the anti-filaggrin antibody, whereas tonofilament clumps did not show any reaction. In epidermolysis bullosa herpetiformis Dowling-Meara the abnormal filament aggregation occurred in basal cell keratins where no reaction of the anti-filaggrin antibody was detected. In high level keratinocytes with normal distribution of tonofilaments, normal stellate keratohyalin reacted specifically. In all instances keratin filament clumping occurred independently of, and spatially separated from, the first signs of profilaggrin synthesis and keratohyalin granule formation. Thus, in these disorders, filaggrin is not involved in filament aggregation.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Weidenthaler B,Hausser I,Anton-Lamprecht Idoi
10.1007/BF01112911subject
Has Abstractpub_date
1993-01-01 00:00:00pages
111-20issue
3eissn
0340-3696issn
1432-069Xjournal_volume
285pub_type
杂志文章abstract：:This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000176
更新日期：2000-11-01 00:00:00
abstract：:Whereas the inflammatory infiltrates of malignant melanoma have been widely investigated, little is known about the infiltrates accompanying benign melanocytic naevi. Using monoclonal antibodies directed against HLA-DR antigens, the CD1 antigen, the transferrin receptor and functionally divergent macrophage subpopulat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372703
更新日期：1992-01-01 00:00:00
abstract：:Sixteen malignant melanoma patients with different levels of tumor progression, two patients with melanoma in situ (Clark 10 two bronchogenic carcinoma patients and nine healthy controls were tested by means of the leukocyte adherence inhibition (LAI) test to assess the function of their cellular mediated immunity. Bl...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403801
更新日期：1980-01-01 00:00:00
abstract：:The mechanism of action of thalidomide in the treatment of patients with Behçet's disease (BD) is poorly understood. There is some evidence to suggest that certain immunological abnormalities are associated with the pathogenesis of BD. A BD-like mouse model induced by herpes simplex virus (HSV) inoculation shows simil...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-004-0498-8
更新日期：2004-09-01 00:00:00
abstract：:Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1582-y
更新日期：2015-10-01 00:00:00
abstract：:Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1828-6
更新日期：2018-07-01 00:00:00
abstract：:Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505821
更新日期：1996-03-01 00:00:00
abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen...
journal_title：Archives of dermatological research
pub_type： 历史文章,杂志文章
doi：10.1007/s00403-002-0328-9
更新日期：2002-08-01 00:00:00
abstract：:In this study we investigated the influence of keratinocytes on the phenotype of fibroblasts in an in vitro human skin equivalent. Keratinocytes were seeded at the surface of fibroblast-populated mechanically restrained type I collagen gels (lattices). Lattices without keratinocytes were handled in parallel as control...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371739
更新日期：1995-01-01 00:00:00
abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412706
更新日期：1979-05-29 00:00:00
abstract：:We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00511066
更新日期：1984-01-01 00:00:00
abstract：:Six cases of dermatofibrosarcoma protuberans were studied ultrastructurally. Biopsy material from all six cases as well as cell cultures derived from four cases were examined. In all cases, the tumor cells in vivo and in vitro were related to fibroblasts. The two cases with histiocytoid features and a small spiral pat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409221
更新日期：1985-01-01 00:00:00
abstract：:The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509237
更新日期：1985-01-01 00:00:00
abstract：:Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0542-3
更新日期：2005-04-01 00:00:00
abstract：:Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1053-4
更新日期：2010-10-01 00:00:00
abstract：:Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404316
更新日期：1985-01-01 00:00:00
abstract：:The prolongation of the S-phase, characteristic of psoriatic keratinocytes, can be observed in cells of the eccrine sweat glands as well as in those of the infundibular part of hair follicles. In healthy individuals the average duration of DNA-synthesis time (ts) in the cells of the hair follicle is 6.8 h, in unaffect...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404286
更新日期：1980-01-01 00:00:00
abstract：:Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1397-7
更新日期：2014-03-01 00:00:00
abstract：:Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0856-z
更新日期：2008-08-01 00:00:00
abstract：:The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Recently a new thin layer chromatography plate (Whatman LK 6D) became available which is extremely easy to handle and permits highly reproducible qualitative and quantitative analysis. This plate proved to be of great value for the investigation of skin surface lipids. The use of a fatty acid methyl ester as an intern...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412383
更新日期：1979-07-30 00:00:00
abstract：:Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1332-y
更新日期：2013-07-01 00:00:00
abstract：:An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00424270
更新日期：1989-01-01 00:00:00
abstract：:One of the primary events in the pathogenesis of acne vulgaris is abnormal follicular keratinization. Since oral isotretinoin therapy reduces follicular hyperkeratinization in acne, our study has been designed to determine whether epidermal lipid composition of the epithelium of sebaceous follicles is affected by isot...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417712
更新日期：1988-01-01 00:00:00
abstract：:In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418572
更新日期：1979-11-01 00:00:00
abstract：:An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694628
更新日期：1979-10-01 00:00:00
abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000160
更新日期：2000-09-01 00:00:00
abstract：:Three per cent boric acid incorporated in an anhydrous, water-emulsifying ointment causes no increase of boron levels in blood and urine during a period of 1-9 days after a single topical application. The same amount of boric acid incorporated in a water-based jelly does cause an increase in blood and urine levels, be...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00510389
更新日期：1982-01-01 00:00:00
abstract：:Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412927
更新日期：1986-01-01 00:00:00
