Abstract：
:Whereas the inflammatory infiltrates of malignant melanoma have been widely investigated, little is known about the infiltrates accompanying benign melanocytic naevi. Using monoclonal antibodies directed against HLA-DR antigens, the CD1 antigen, the transferrin receptor and functionally divergent macrophage subpopulations, frozen fresh material of 87 melanocytic naevi (MN), ten primary cutaneous melanomas (PCM) and ten samples of normal skin were studied. Compared with normal skin, abundant HLA-DR+ cells were found in the stroma of MN equivalent to the quantity present in PCM. In MN we found higher numbers of dermal CD1+ dendritic cells compared with PCM and normal skin. There were more macrophages that expressed the transferrin receptor or the antigens 27E10, RM3/1 and 25F9 in MN than in normal skin but fewer than in PCM. No significant differences were found between congenital MN (n = 40), common acquired MN (n = 27) and dysplastic MN (n = 20) macrophage subpopulations. Also, no correlations were evident between macrophage infiltrates and naevus location or patients' age. Our data show that potential melanoma precursors among melanocytic naevi cannot be identified by the pattern of macrophage infiltrates.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Bröcker EB,Reckenfeld C,Hamm H,Ruiter DJ,Sorg Cdoi
10.1007/BF00372703keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
127-31issue
3eissn
0340-3696issn
1432-069Xjournal_volume
284pub_type
杂志文章abstract：:The adenylate cyclase system of an established human trichilemmoma cell line was investigated. Stimulators of human epidermal adenylate cyclase system, epinephrine, histamine, adenosine, and prostaglandin E increased cyclic AMP levels of the trichilemmoma cells. The effects of epinephrine, histamine, and adenosine wer...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00413285
更新日期：1987-01-01 00:00:00
abstract：:In order to find, whether 8-MOP has an inhibiting effect on the proliferation of lymphocytes in the dark, we studied in vitro the lymphocyte proliferation by a mitogen (HgCl2) and by an antigen (tuberculin) from 16 psoriatic patients during the first oral PUVA treatment immediately before 8-MOP intake (03.--0.5 mg/kg ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455295
更新日期：1978-05-31 00:00:00
abstract：:HaCaT keratinocytes differ from normal human epidermal keratinocytes (HEK) by constitutive expression of differentiation markers which are normally suppressed by vitamin A. In search of an explanation for this discrepancy we compared the vitamin A content, the expression of retinoid-binding proteins, and the vitamin A...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050419
更新日期：1999-06-01 00:00:00
abstract：:An aromatic retinoid (Ro 10-9359) in 13-cis retinoic acid (Ro 4-3780) were fed by gastric tube to 170 male adult Syrian hamsters daily for 30 days. A low dose of 1 or 2 mg/kg and a high dose of 20 mg/kg body weight were selected. The effects of both retinoids on the sebaceous glands were assessed planimetrically (15 g...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404284
更新日期：1980-01-01 00:00:00
abstract：:Abnormal dermal deposition of elastic fibers is the earliest and most striking effect of prolonged sun exposure (solar elastosis). The hyperplastic fibers are usually ascribed to ultraviolet (UV) rays. Nonetheless, other portions of the solar spectrum may play contributing roles. Heat, for example, enhances experiment...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509050
更新日期：1982-01-01 00:00:00
abstract：:We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00511066
更新日期：1984-01-01 00:00:00
abstract：:Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0357-4
更新日期：2003-01-01 00:00:00
abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412706
更新日期：1979-05-29 00:00:00
abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412495
更新日期：1985-01-01 00:00:00
abstract：:Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0938-6
更新日期：2009-04-01 00:00:00
abstract：:A procedure measuring the ornithine decarboxylase (ODC) activity and polyamine formation of intact neonatal mouse epidermal cells in culture has been developed and tested. Basal cells prepared from neonatal mouse epidermis were plated on round 15-mm Lux coverslips, placed in Costar 24 well culture clusters and grown a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509038
更新日期：1982-01-01 00:00:00
abstract：:Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1685-0
更新日期：2016-11-01 00:00:00
abstract：:Interleukin-6-like (IL-6-like) immunoreactivity was sought in inflamed and normal human skin using the same immunohistochemical technique as for detection of neuropeptides. Such immunoreactivity was found in dermal and in a few intraepidermal nerve-like fibres in biopsy specimens from inflamed skin from patients with ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505230
更新日期：1996-07-01 00:00:00
abstract：:Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-011-1166-4
更新日期：2011-11-01 00:00:00
abstract：:In the present study the action of various cytokines as regulators of human melanocyte growth and differentiation was examined in vitro. Primary melanocyte cultures were obtained in complete medium free of 12-O-tetradecanoylphorbol-13-acetate or serum. First passage melanocytes were treated with various concentrations...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01105076
更新日期：1995-01-01 00:00:00
abstract：:To investigate the turnover of complete junctional membrane areas ("domain turnover"), psoriatic epidermis, keratoacanthoma, and squamous cell carcinoma were studied with an electron microscope and compared with the normal epidermis. Three types of domain turnover of junctions were observed. First, the uptake of intac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00510363
更新日期：1982-01-01 00:00:00
abstract：:The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050308
更新日期：1998-06-01 00:00:00
abstract：:The mechanism of action of thalidomide in the treatment of patients with Behçet's disease (BD) is poorly understood. There is some evidence to suggest that certain immunological abnormalities are associated with the pathogenesis of BD. A BD-like mouse model induced by herpes simplex virus (HSV) inoculation shows simil...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-004-0498-8
更新日期：2004-09-01 00:00:00
abstract：:A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404624
更新日期：1984-01-01 00:00:00
abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1863-3
更新日期：2018-11-01 00:00:00
abstract：:The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00426583
更新日期：1989-01-01 00:00:00
abstract：:Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050195
更新日期：1997-04-01 00:00:00
abstract：:The prolongation of the S-phase, characteristic of psoriatic keratinocytes, can be observed in cells of the eccrine sweat glands as well as in those of the infundibular part of hair follicles. In healthy individuals the average duration of DNA-synthesis time (ts) in the cells of the hair follicle is 6.8 h, in unaffect...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404286
更新日期：1980-01-01 00:00:00
abstract：:Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1797-1
更新日期：2018-03-01 00:00:00
abstract：:An animal experiment is presented in which two groups of pigmented hairless mice were exposed daily to suberythemal doses of UVA to study tumourigenesis. The aim of the study was to estimate the carcinogenic risks of tanning by UVA. The pigmented hairless mice, Skh-hr2, were separated by selective breeding into two gr...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00375721
更新日期：1990-01-01 00:00:00
abstract：:Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-011-1177-1
更新日期：2012-03-01 00:00:00
abstract：:The aim of this study was to investigate the presence and density of the nerve fibre-marker protein gene product 9.5 (PGP 9.5), with immunohistochemistry, in skin from patients with hidradenitis suppurativa (HS). Punch biopsies were obtained from 16 patients; 10 with involvement of the groin and six with axillary dise...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1028-5
更新日期：2010-08-01 00:00:00
abstract：:Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in whic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0664-2
更新日期：2006-06-01 00:00:00
abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418573
更新日期：1979-11-01 00:00:00
abstract：:Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognitio...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-017-1790-8
更新日期：2018-03-01 00:00:00
