Abstract：
:An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement membrane and several pericytes. Both endothelial cells and pericytes were of normal ultrastructural appearance. Intervascular "stromal" cells were few and morphologically identified as macrophages and/or phagocytic fibroblasts. Masses of hemosiderin were detected outside the cells and in the macrophages, endothelial cells, and pericytes. Intracytoplasmatic crystalloid inclusions similar to those found in fetal endothelium and hemangiomas were observed in a few endothelial cells. These findings are different from those of previously reported cases of pseudo-Kaposi's sarcoma and may be helpful in distinguishing Kaposi's sarcoma from BSS. The role of immunodeficiency in the onset of BSS is discussed.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Fimiani M,Simoni S,Miracco C,De Santi M,Luzi P,Andreassi Ldoi
10.1007/BF00424270subject
Has Abstractpub_date
1989-01-01 00:00:00pages
35-9issue
1eissn
0340-3696issn
1432-069Xjournal_volume
281pub_type
杂志文章abstract：:The effect of the proteolytic enzyme savinase on human plantar skin in vitro was examined by light and electron microscopy to elucidate the morphological involvement of activated savinase in human epidermis. Light microscopic examination of incubated skin fragments demonstrated that the histological changes produced b...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371819
更新日期：1991-01-01 00:00:00
abstract：:Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505252
更新日期：1996-08-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-013-1381-2
更新日期：2013-09-01 00:00:00
abstract：:Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CE...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372069
更新日期：1992-01-01 00:00:00
abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02507101
更新日期：1996-06-01 00:00:00
abstract：:Epstein-Barr virus (EBV) can infect epithelial cells as well as B lymphocytes. Infection of the male and female genital tracts has recently been demonstrated, and it has been suggested that the virus may be sexually transmissible. In our study we investigated whether EBV can be found in the anal region of sexually act...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00374084
更新日期：1995-01-01 00:00:00
abstract：:Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1347-4
更新日期：2013-08-01 00:00:00
abstract：:Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050479
更新日期：2000-05-01 00:00:00
abstract：:Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1340-y
更新日期：2013-08-01 00:00:00
abstract：:In this study we investigated the influence of keratinocytes on the phenotype of fibroblasts in an in vitro human skin equivalent. Keratinocytes were seeded at the surface of fibroblast-populated mechanically restrained type I collagen gels (lattices). Lattices without keratinocytes were handled in parallel as control...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371739
更新日期：1995-01-01 00:00:00
abstract：:An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694628
更新日期：1979-10-01 00:00:00
abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050398
更新日期：1999-04-01 00:00:00
abstract：:A 50-year-old male patient had three episodes of acrally located purpura within 12 years without any other symptoms. The first two episodes which lasted several months coincided with the intake of beta-blockers; the third episode developed after a respiratory infection. A cryofibrinogenemia was found without any evide...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585916
更新日期：1987-01-01 00:00:00
abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0683-z
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02182-y
更新日期：2021-01-12 00:00:00
abstract：:The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00493466
更新日期：1990-01-01 00:00:00
abstract：:Ionotrope glutamate receptors of the N-methyl-D-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-004-0505-0
更新日期：2004-09-01 00:00:00
abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...
journal_title：Archives of dermatological research
pub_type： 信件
doi：10.1007/s00403-004-0508-x
更新日期：2004-10-01 00:00:00
abstract：:The demonstration of cytokine mRNA expression in epidermal cells by the polymerase chain reaction technique preceded by reverse transcription (RT-PCR) requires linear test conditions (i.e. that the product obtained after amplification reflects the relative amounts of starting material) and high reproducibility, specif...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370722
更新日期：1994-01-01 00:00:00
abstract：:Biopsy specimens from mixed connective tissue disease (MCTD) and discoid lupus erythematodes (DLE) skin lesions were stained with monoclonal antibodies to differentiation and activation antigens. In addition, the blast cells were studied by combining autoradiography with immunoperoxidase staining. In both disease cond...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412679
更新日期：1988-01-01 00:00:00
abstract：:Besides its role in small-cell carcinoma of the lung, elevated serum levels of neuron-specific enolase (NSE) have recently been reported to be associated with autoimmune rheumatic disorders such as systemic sclerosis. Serum NSE seems to correlate with disease activity as well as Rodnan skin score. The aim of the study...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-004-0495-y
更新日期：2004-09-01 00:00:00
abstract：:Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1332-y
更新日期：2013-07-01 00:00:00
abstract：:The histological and ultrastructural effects following 3 weeks' topical treatment with two agents (all-trans retinoic acid and a new synthetic retinoid-like substance, CD271) were evaluated on the epidermis and the epithelial wall of the pseudocomedones in rhino mouse skin. The comedolytic effects of these drugs were ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371617
更新日期：1991-01-01 00:00:00
abstract：:Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-r...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1218-4
更新日期：2012-03-01 00:00:00
abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-014-1480-8
更新日期：2014-12-01 00:00:00
abstract：:Dopamine causes reflex erythema, central blanching, and piloerection depending on the dose and the type of application wheal reaction. Intracutaneous application shows from 1.5 gamma/0.1 ml wheal formation, erythema, piloerection, and blanching combined with increased heat radiation from the skin surface (AGA thermovi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412863
更新日期：1979-08-01 00:00:00
abstract：:The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00426583
更新日期：1989-01-01 00:00:00
abstract：:Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417145
更新日期：1981-01-01 00:00:00
abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-016-1638-7
更新日期：2016-07-01 00:00:00
abstract：:Genetic abnormalities for different subtypes of epidermolysis bullosa (EB) have been described. In dominant simplex type EB, mutations of the K5 or K14 gene lead to disruption of basal cells and the formation of bullae. The recessive simplex types include EB with muscular dystrophy due to abnormal plectin, EB without ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-002-0369-0
更新日期：2003-04-01 00:00:00
