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The relationship between severity of the disease and circulating nucleosomes in psoriasis patients.

Abstract：

:Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an important factor affecting the apoptosis. In the present study, the relationship between TNF-α, nucleosome and the Psoriasis Area and Severity Index (PASI) score was investigated. The patients were divided according to PASI score into three groups (mild, moderately, severe). Serum TNF-α and nucleosome levels were measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings show a correct relationship between PASI scores and TNF-α and an inverse relationship between nucleosome and PASI score. According to the results obtained from the study, we believe that serum nucleosome levels can be used as a new indicator in follow-up of patients with psoriasis and monitoring of the effectiveness of drugs which used in the treatment of psoriasis.

journal_name

Arch Dermatol Res

journal_title

Archives of dermatological research

authors

Dilek AR,Dilek N,Saral Y,Yüksel D

doi

10.1007/s00403-013-1347-4

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

483-7

issue

6

eissn

0340-3696

issn

1432-069X

journal_volume

305

pub_type

杂志文章

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