Abstract:
:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1 and mTORC2 as well as their upstream modulators, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), and their downstream targets in various dermatologic diseases. Phytochemicals, plant-derived naturally occurring compounds, have been shown to regulate the mTOR pathway and may serve as novel therapeutic agents in dermatological disease. Here, we review phytochemicals in the context of the mTOR pathway and their potential use in cutaneous disease.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Leo MS,Sivamani RKdoi
10.1007/s00403-014-1480-8subject
Has Abstractpub_date
2014-12-01 00:00:00pages
861-71issue
10eissn
0340-3696issn
1432-069Xjournal_volume
306pub_type
杂志文章,评审abstract::Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00505639
更新日期:1990-01-01 00:00:00
abstract::The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone wi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00416669
更新日期:1983-01-01 00:00:00
abstract::Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0804-3
更新日期:2008-04-01 00:00:00
abstract::The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed b...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02165-z
更新日期:2020-11-22 00:00:00
abstract::It has been suggested that free fatty acids (FFA) such as palmitate, which are secreted from enlarged adipocytes in the subcutaneous fat of obese subjects, serve as a link between obesity and altered skin functions. Cyclooxygenease-2 (COX-2) and prostanoids participate in the induction of impaired dermal function. In ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1434-6
更新日期:2014-05-01 00:00:00
abstract::The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HAN...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00413358
更新日期:1984-01-01 00:00:00
abstract::In the study described here we investigated the possibility of an association between the aggressiveness of melanoma and multidrug resistance phenotype by analyzing the expression and activity of P-glycoprotein (Pgp) in two genetically related transplantable hamster melanomas--a melanotic (Ma) and an amelanotic (Ab) f...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030000146
更新日期:2000-07-01 00:00:00
abstract::The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00418573
更新日期:1979-11-01 00:00:00
abstract::Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-011-1166-4
更新日期:2011-11-01 00:00:00
abstract::Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidan...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01976-z
更新日期:2020-01-01 00:00:00
abstract::Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin de...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412738
更新日期:1990-01-01 00:00:00
abstract::Photodynamic therapy (PDT) in dermatology has been proven to be a successful noninvasive therapeutic modality for treating skin cancer. To facilitate its clinical introduction, the development of topical photosensitizers is necessary to avoid generalized, cutaneous photosensitivity. Therefore the penetration of synthe...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050168
更新日期:1997-02-01 00:00:00
abstract::Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effect...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01935-8
更新日期:2019-09-01 00:00:00
abstract::The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNF alpha) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372709
更新日期:1992-01-01 00:00:00
abstract::Dopamine causes reflex erythema, central blanching, and piloerection depending on the dose and the type of application wheal reaction. Intracutaneous application shows from 1.5 gamma/0.1 ml wheal formation, erythema, piloerection, and blanching combined with increased heat radiation from the skin surface (AGA thermovi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412863
更新日期:1979-08-01 00:00:00
abstract::Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01112911
更新日期:1993-01-01 00:00:00
abstract::Solar ultraviolet (UV) irradiation causes damages on human skin and premature skin aging (photoaging). UV-induced reduction of type I collagen in dermis is widely considered primarily induction of wrinkled appearance of photoaging skin. Type I procollagen synthesis is reduced under UV irradiation by blocking transform...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0805-2
更新日期:2008-04-01 00:00:00
abstract::Myotonic muscular dystrophy (MMD) is caused by an abnormal function of RNA-binding proteins (RBP) resulting in DNA spliceopathy. A case of a patient, with MMD multiple basal and squamous cell carcinomas and dysplastic nevi, is described. The association between MMD and non-melanoma skin cancer has been reported before...
journal_title:Archives of dermatological research
pub_type: 新闻
doi:10.1007/s00403-009-0997-8
更新日期:2010-04-01 00:00:00
abstract::In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/BF00638233
更新日期:1992-01-01 00:00:00
abstract::The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050218
更新日期:1997-07-01 00:00:00
abstract::A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated. All the 13 patients with keloids revealed in the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403728
更新日期:1982-01-01 00:00:00
abstract::Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. M...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1753-0
更新日期:2017-09-01 00:00:00
abstract::Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0357-4
更新日期:2003-01-01 00:00:00
abstract::Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional sur...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02118-6
更新日期:2020-08-09 00:00:00
abstract::Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505821
更新日期:1996-03-01 00:00:00
abstract::A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404624
更新日期:1984-01-01 00:00:00
abstract::The established mouse epidermis-derived cell line HEL/30 was incubated in the presence of 3H arachidonic acid (AA) for 1 h. After medium removal, cells were reincubated with fresh medium in the presence or absence of the calcium ionophore A23187 and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The AA me...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00429984
更新日期:1988-01-01 00:00:00
abstract::Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1177-1
更新日期:2012-03-01 00:00:00
abstract::Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00412560
更新日期:1984-01-01 00:00:00