Abstract：
:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Balato A,Raimondo A,Balato N,Ayala F,Lembo Sdoi
10.1007/s00403-016-1638-7subject
Has Abstractpub_date
2016-07-01 00:00:00pages
287-96issue
5eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-016-1638-7journal_volume
308pub_type
杂志文章,评审abstract：:1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00446949
更新日期：1978-12-01 00:00:00
abstract：:Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. B. Grassi were invited to participate in the study (n = 395). Infor...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01911-2
更新日期：2019-07-01 00:00:00
abstract：:The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050474
更新日期：2000-04-01 00:00:00
abstract：:Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CE...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372069
更新日期：1992-01-01 00:00:00
abstract：:This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000176
更新日期：2000-11-01 00:00:00
abstract：:Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00403-012-1297-2
更新日期：2013-04-01 00:00:00
abstract：:Previous studies have demonstrated that permeability barrier disruption by acetone treatment significantly enhances skin permeability to both hydrophilic and amphipathic compounds, but not to highly lipophilic compounds. The purpose of the present study was to investigate the dependence of permeability on molecular we...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100229
更新日期：2001-06-01 00:00:00
abstract：:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1589-4
更新日期：2015-11-01 00:00:00
abstract：:Recent evidence indicates that the biologically active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], has an effect on the regulation of the immune response. We investigated whether topical treatment of mice with 1 alpha,25(OH)2D3 influences the contact hypersensitivity (CHS) response to...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412982
更新日期：1989-01-01 00:00:00
abstract：:It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000142
更新日期：2000-08-01 00:00:00
abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412495
更新日期：1985-01-01 00:00:00
abstract：:Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0628-y
更新日期：2006-03-01 00:00:00
abstract：:In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Painting of 3,3',4',5-tetrachlorosalicylanilide (TCSA) plus ultraviolet A (UVA) irradiation to the same site induces contact photosensitivity (CPS), but at the same time results in death of the photohapten-modified cells. Using an in vitro immune lymph node cell (LNC) proliferation system, we investigated the mechanis...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372063
更新日期：1991-01-01 00:00:00
abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1487-1
更新日期：2014-10-01 00:00:00
abstract：:Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0747-8
更新日期：2007-06-01 00:00:00
abstract：:The aim of the present study was to investigate the influence of three different retinoids, isotretinoin, etretinate and acitretin, on the mitogenic response of peripheral blood mononuclear cells (PBMCs) to PHA and PMA in vitro. All three retinoids at high concentrations (10(-4)M) significantly inhibited the mitogenic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050291
更新日期：1998-04-01 00:00:00
abstract：:The expression and location of the Ki-67 antigen was investigated in 62 basal cell carcinomas (BCC) using immunostaining techniques (PAP and APAAP) on cryostat sections. The tumor samples were classified into three groups according to microarchitecture (nodular, superficial or fibrosing). The Ki-67 growth fraction dis...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371599
更新日期：1993-01-01 00:00:00
abstract：:Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00407745
更新日期：1986-01-01 00:00:00
abstract：:The deposition of immunoglobulin (Ig) at the dermo-epidermal junction (DEJ) of the skin, frequently observed in autoimmune mouse strains, is similar to that seen in patients with systemic lupus erythematosus (SLE). MRL/Mp-lpr/lpr (MRL/lpr) mice have an autosomal recessive mutant gene, lpr, which produces massive T-cel...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370818
更新日期：1993-01-01 00:00:00
abstract：:The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate. We studied 187 women with alopecia, which we graded I, II, or III, according to Ludwig's classification, and 21 healthy control women. All participants were subjected to...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000184
更新日期：2000-12-01 00:00:00
abstract：:Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01976-z
更新日期：2020-01-01 00:00:00
abstract：:The penetration and permeation of the recombinant protein plasminogen activator inhibitor type 2 (PAI-2) in two formulations, one containing a penetration enhancer, into the psoriatic and uninvolved skin of eight patients with plaque-type psoriasis were investigated. Penetration and permeation of PAI-2 were measured b...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-003-0425-4
更新日期：2003-11-01 00:00:00
abstract：:Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-bind...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0610-8
更新日期：2005-12-01 00:00:00
abstract：:The effect of the proteolytic enzyme savinase on human plantar skin in vitro was examined by light and electron microscopy to elucidate the morphological involvement of activated savinase in human epidermis. Light microscopic examination of incubated skin fragments demonstrated that the histological changes produced b...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371819
更新日期：1991-01-01 00:00:00
abstract：:Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0645-5
更新日期：2006-07-01 00:00:00
abstract：:The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1298-1
更新日期：2013-04-01 00:00:00
abstract：:As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412496
更新日期：1985-01-01 00:00:00
abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
