Abstract:
:Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-binding substance, antimicrobial agent and preservative and may therefore replace several ingredients in a skin composition. The release of tri-iodothyroacetic acid (TRIAC) and percutaneous absorption of hydrocortisone and mometasone furoate with either pentane-1,5-diol or propane-1,2-diol and 2-methyl-pentane-2,4-diol (hexylene glycol), respectively, as enhancers was compared. The release of TRIAC was 21% higher when pentane-1,5-diol was used as an enhancer instead of propane-1,2-diol. The percutaneous absorption of hydrocortisone through the skin was increased 12 times with propane-1,2-diol compared to 4.4 times with pentane-1,5-diol. However, the percutaneous absorption of hydrocortisone into the skin was 50% higher with pentane-1,5-diol compared to propane-1,2-diol. There was no significant difference, between the original mometasone furoate cream, with 2-methyl-pentane-2,4-diol, and the new cream with pentane-1,5-diol in the amount of mometasone furoate that was absorbed into the skin and through the skin. However, the cosmetic properties of the new mometasone furoate cream was superior to the original mometasone furoate cream, for examples, no bad odour, more even texture, goes better into the skin and has less greasiness. Pentane-1,5-diol can be used as a technology platform, which adds a series of desirable properties to dermatological preparations and enhances product usability. This will result in improved formulations for a series of major and commonly used dermatological drugs. When used in pharmaceutical topical preparations, pentane-1,5-diol will increase the percutaneous absorption of the active substance and it is an efficient antimicrobial agent that will act as an effective preservative in topical formulations. Pentane-1,5-diol is cosmetically attractive, has low risk for skin and eye irritation compared to other diols, low toxicity risk and no bad odour.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Faergemann J,Wahlstrand B,Hedner T,Johnsson J,Neubert RH,Nyström L,Maibach Hdoi
10.1007/s00403-005-0610-8keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
261-5issue
6eissn
0340-3696issn
1432-069Xjournal_volume
297pub_type
杂志文章abstract::Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1494-2
更新日期:2014-11-01 00:00:00
abstract::Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505821
更新日期:1996-03-01 00:00:00
abstract::The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone wi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00416669
更新日期:1983-01-01 00:00:00
abstract::Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01896-y
更新日期:2019-05-01 00:00:00
abstract::Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0856-z
更新日期:2008-08-01 00:00:00
abstract::Epstein-Barr virus (EBV) can infect epithelial cells as well as B lymphocytes. Infection of the male and female genital tracts has recently been demonstrated, and it has been suggested that the virus may be sexually transmissible. In our study we investigated whether EBV can be found in the anal region of sexually act...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00374084
更新日期:1995-01-01 00:00:00
abstract::An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424270
更新日期:1989-01-01 00:00:00
abstract::HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00409265
更新日期:1982-01-01 00:00:00
abstract::Vitiliginous patients undergoing photochemotherapy with TMP were less susceptible to a sun burn. To investigate this point, the MED for UV-B was measured before, 2 h, and 24 h after oral intake of TMP in 10 healthy volunteers. There was an increase of MED when UV exposure had taken place 2 h after TMP intake (P < 0.01...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403890
更新日期:1980-01-01 00:00:00
abstract::The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00426614
更新日期:1988-01-01 00:00:00
abstract::Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1689-9
更新日期:2016-12-01 00:00:00
abstract::Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1582-y
更新日期:2015-10-01 00:00:00
abstract::GM-CSF is known primarily as a hematopoietic growth factor, but it has also been shown to inhibit mast cell differentiation in vitro. In order elucidate the mechanisms involved, we investigated the effects of GM-CSF in vitro on the differentiation of human leukemic mast cells (HMC-1 cells) and normal cord blood-derive...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030100225
更新日期:2001-05-01 00:00:00
abstract::Mice homozygous for three different recessive mutations known to cause pleiotropic defects in the immune system and in the skin were used to evaluate the relationship between the classical immune system and dendritic epidermal cell populations. Numbers of Langerhans cells (LCs) and Thy-1+ dendritic cells (Thy-1+DEC) w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372621
更新日期:1990-01-01 00:00:00
abstract::Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1581-z
更新日期:2015-08-01 00:00:00
abstract::Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372058
更新日期:1991-01-01 00:00:00
abstract::Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00403-012-1297-2
更新日期:2013-04-01 00:00:00
abstract::The cellular DNA ploidy of 30 cases of malignant melanoma was measured by 4',6-diamidino-2-phenylindole-DNA (DAPI-DNA) microfluorometry. DNA histograms and DNA index values were compared among melanomas of different cell morphology. Epithelioid cell melanomas often showed greater DNA aneuploidy than spindle cell melan...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372134
更新日期:1993-01-01 00:00:00
abstract::Vitiligo is an acquired clinical conundrum, characterized by white areas on the skin due to loss of functional melanocytes. Various studies demonstrated that vitiligo is associated with fewer risk of skin cancer but no exact molecular explanation for this interesting observation has been described. This article review...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-011-1165-5
更新日期:2011-11-01 00:00:00
abstract::The fetal development of Merkel cells-neuroendocrine cells of the skin - has been a matter of debate for a long time. Recent results have helped to confirm their intraepidermal development in humans. Simple epithelial cytokeratins (CK) nos. 8, 18, 19 and 20 are well established markers at the light microscopic level. ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505222
更新日期:1996-04-01 00:00:00
abstract::In this study we investigated the influence of keratinocytes on the phenotype of fibroblasts in an in vitro human skin equivalent. Keratinocytes were seeded at the surface of fibroblast-populated mechanically restrained type I collagen gels (lattices). Lattices without keratinocytes were handled in parallel as control...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371739
更新日期:1995-01-01 00:00:00
abstract::A 61-year old woman developed a tumourous nodule in her left leg. Fifteen years ago a similar tumour had been removed in the same localization. Histological examination performed on biopsy material showed bundles of predominantly fusiform tumour cells with nuclear pleomorphism and many mitotic figures. Electron micros...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00446437
更新日期:1978-11-10 00:00:00
abstract::CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1863-3
更新日期:2018-11-01 00:00:00
abstract::Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403786
更新日期:1981-01-01 00:00:00
abstract::Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacu...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00694624
更新日期:1979-10-01 00:00:00
abstract::The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050308
更新日期:1998-06-01 00:00:00
abstract::Primary hyperhidrosis is a condition characterized by excessive sweating. The estimated prevalence is between 0.6 and 4.4%, and it can have economic, psychological, and social consequences for affected individuals. Family and genetic studies have suggested a genetic component in the inheritance of the disease. In this...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-019-01966-1
更新日期:2019-12-01 00:00:00
abstract::Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0357-4
更新日期:2003-01-01 00:00:00
abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1095-7
更新日期:2011-07-01 00:00:00
abstract::Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix (ECM) in the dermis. It is a late spreading skin overgrowth and may be considered a plastic surgeon's nightmare. In nature, curcuminoid is composed of curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (bDMC). Curcumino...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1075-y
更新日期:2010-12-01 00:00:00