Abstract：
:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospectively from January to April 2012 at the Peking Union Medical College Hospital. Only cutaneous ADRs induced by systemic drugs were considered. Fifty cases were confirmed as cutaneous ADRs, for an estimated incidence of 2.2 per 1000 during this period (95 % confidence interval 1.6-2.8). Cases of cutaneous ADRs comprised 69 % females, while 63 % of all inpatients were female (χ (2) = 0.641, P = 0.427). The department of infectious diseases was the most frequently involved department. Morbilliform exanthema (40 %) was the most frequent cutaneous ADR, followed by urticaria (23.1 %). Anti-infection drugs (36.9 %) caused most cases of cutaneous ADRs, followed by iodinated contrast media (ICM, 18.5 %) and non-steroidal anti-inflammatory drugs (NSAIDs, 18.5 %). The most frequently associated disorders were cancer (24 %), infection (22 %), cardiovascular and cerebrovascular diseases (20 %), and autoimmune diseases (18 %). In this first prospective study assessing the incidence of cutaneous ADRs in China, anti-infection drugs were the most commonly involved drugs, followed by ICM and NSAIDs. No evidence of increased cutaneous ADR incidence in AIDS or SLE patients was observed. Our findings indicate that cancer and its treatments were often related to cutaneous ADRs in China.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Tian XY,Liu B,Shi H,Zhao ZR,Zhou XP,Zhang T,Sun QN,Zuo YGdoi
10.1007/s00403-015-1589-4subject
Has Abstractpub_date
2015-11-01 00:00:00pages
829-34issue
9eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-015-1589-4journal_volume
307pub_type
杂志文章abstract：:There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients witho...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1875-z
更新日期：2019-01-01 00:00:00
abstract：:A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00402624
更新日期：1990-01-01 00:00:00
abstract：:To have as further insight into the localizations of immune deposits in the skin the reversed passive and the passive Arthus reactions were carried out in the foot-pads skin of guinea-pigs using horseradish peroxidase as antigen. The transient localizations of immune deposits in the papillary dermis and in the epiderm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404457
更新日期：1980-01-01 00:00:00
abstract：:The incidence of epithelioid sarcoma among patients with malignant soft tissue tumors is small, but the rates of recurrence and metastasis of this type of sarcoma are high. To date, effective chemotherapy for advanced epithelioid sarcoma has not been established and, furthermore, epithelioid sarcoma is known to exhibi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000127
更新日期：2000-06-01 00:00:00
abstract：:Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505821
更新日期：1996-03-01 00:00:00
abstract：:A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371642
更新日期：1990-01-01 00:00:00
abstract：:The effects of acidic and basic fibroblast growth factors (aFGF and bFGF, respectively) on proliferation and differentiation of cultured hair apparatus cells were examined using bovine pituitary extract (BPE)-free media. The importance of FGFs as growth factors in BPE was also examined. Both FGFs and BPE stimulated ce...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371577
更新日期：1994-01-01 00:00:00
abstract：:The cellular DNA ploidy of 30 cases of malignant melanoma was measured by 4',6-diamidino-2-phenylindole-DNA (DAPI-DNA) microfluorometry. DNA histograms and DNA index values were compared among melanomas of different cell morphology. Epithelioid cell melanomas often showed greater DNA aneuploidy than spindle cell melan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372134
更新日期：1993-01-01 00:00:00
abstract：:Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01896-y
更新日期：2019-05-01 00:00:00
abstract：:Adult female Wistar rats (n = 48) divided into four groups of 12 were treated orally with 3 mg/kg per day thalidomide, a 0.05% hexachlorobenzene (HCB)--containing diet, with both drugs together and with the vehicles (controls) over periods of 10 and 60 days. The protein and P450 contents and the activities of aminopyr...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00402227
更新日期：1994-01-01 00:00:00
abstract：:The incidence of cutaneous malignant melanoma continues to rise. Strategies to reduce mortality in this situation include improving therapy, encouraging earlier diagnosis, and promoting prevention. New developments such as epiluminescence, sentinel node biopsy, arterial limb perfusion and the use of vaccines are discu...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00370712
更新日期：1994-01-01 00:00:00
abstract：:The composition of the aerobic and anaerobic bacterial skin flora was investigated quantitatively and qualitatively in 25 patients with seborrheic eczema (SE) and in 35 healthy persons. In SE patients, the geometric mean count for propionibacteria in the pilosebaceous ducts of the forehead was reduced to a statistical...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404292
更新日期：1980-01-01 00:00:00
abstract：:No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1882-0
更新日期：2019-01-01 00:00:00
abstract：:Exposure to ultraviolet (UV) irradiation has detrimental effects on skin accompanied by the increased metabolism of hyaluronan (HA), a linear polysaccharide important for the normal physiological functions of skin. In this study, the modulation of human keratinocyte response to UVB irradiation by HA (970 kDa) was inve...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-011-1146-8
更新日期：2011-05-01 00:00:00
abstract：:The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the b...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1283-8
更新日期：2013-01-01 00:00:00
abstract：:As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412496
更新日期：1985-01-01 00:00:00
abstract：:Mouse S91 melanoma cells which grow as a monolayer in culture were studied by transmission and scanning electron microscopy after fixation in situ. The cells were spindle-shaped and tended to grow in dense colonies. Melanosomes at all stages of melanization (stages I-IV) were observed. Other cell organelles reflected ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00431064
更新日期：1989-01-01 00:00:00
abstract：:Although cell death by apoptosis has been recognized as an important control mechanism in the maintenance of tissue homeostasis and in the elimination of cells with damaged DNA, information on the induction and characteristics of apoptosis in keratinocytes is rather scarce. Apoptotic mechanisms may play an important r...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505277
更新日期：1996-10-01 00:00:00
abstract：:Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-011-1161-9
更新日期：2011-12-01 00:00:00
abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000160
更新日期：2000-09-01 00:00:00
abstract：:Serotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functiona...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0909-3
更新日期：2009-07-01 00:00:00
abstract：:Fingernail growth was studied in 28 patients who were receiving systemic treatment with the aromatic retinoid, Ro 10-9359 known as Tigason (etretinate; AR). A group of 15 patients with psoriasis was compared with a group of 13 patients with other dermatoses which are known to have a good response to AR therapy. In the...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00414112
更新日期：1985-01-01 00:00:00
abstract：:To elucidate the interaction between melanoma and its matrix, we cultured B16 murine melanoma cells on and in type I collagen gel and evaluated specified functions of melanoma cells; tyrosinase activity and melanin-synthesizing capacity. Proliferation of cells cultured in these environments was markedly suppressed com...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371647
更新日期：1990-01-01 00:00:00
abstract：:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1681-4
更新日期：2016-11-01 00:00:00
abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0857-y
更新日期：2008-07-01 00:00:00
abstract：:The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly divided into the treatment group (n = 56) and the control group (n = 44). The treatment group was medicated with calcium gluconate (10 mg/ time, 1 time/day), vitamin D3 (i...
journal_title：Archives of dermatological research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00403-019-01967-0
更新日期：2019-12-01 00:00:00
abstract：:This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only sl...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694617
更新日期：1979-10-01 00:00:00
abstract：:Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01262328
更新日期：1995-01-01 00:00:00
abstract：:Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404352
更新日期：1986-01-01 00:00:00
abstract：:Scleroderma is a heterogeneous disease with a complex etiology. As more information is gained about the underlying mechanisms and the improved classifications of scleroderma subtypes, treatments can be better personalized. Improving scleroderma patients' early diagnosis before end organ manifestations occur should imp...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-016-1647-6
更新日期：2016-09-01 00:00:00
