Abstract：
:The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly divided into the treatment group (n = 56) and the control group (n = 44). The treatment group was medicated with calcium gluconate (10 mg/ time, 1 time/day), vitamin D3 (intramuscular 10 mg/time, 1 time/week), mizolastine (10 mg/time, 1 time/day), and proteoglycan (1.2 g/time, 3 times/day), while the control group was administered with the same drugs except proteoglycan for 4 weeks. After treatment with combined mizolastine and proteoglycan, therapeutic effect with symptoms decline index (SDI) more than 60% was significant different (44 vs. 24, p = 0.000973) and the relapse rate after 2 months was significantly lower (17.9% vs. 38.6%, p = 0.0202). Using ELISA, we found that the IFN-γ (37.88 ± 4.27 pg/mL vs. 21.91 ± 4.95 pg/mL, p = 0.028) levels were specifically increased in the experiment group. The combination of mizolastine plus proteoglycan is effective in treating chronic urticaria with better therapeutic effect and lower relapse rate through promoting IFN-γ production.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Xiong X,Song L,Chen F,Ma Xdoi
10.1007/s00403-019-01967-0subject
Has Abstractpub_date
2019-12-01 00:00:00pages
801-805issue
10eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-019-01967-0journal_volume
311pub_type
杂志文章,随机对照试验abstract：:Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0868-8
更新日期：2008-10-01 00:00:00
abstract：:HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409265
更新日期：1982-01-01 00:00:00
abstract：:This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed tha...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00440602
更新日期：1988-01-01 00:00:00
abstract：:A monoclonal antibody (Ted-R-1) to the keratohyalin granules (KHGs) of the newborn rat epidermis was developed by immunizing mice with a pH 4.7 hematoxylin-stainable fraction of the extract in a 50 mM Tris-HCl buffer, pH 7.3, containing 10 micrograms/ml phenylmethylsulfonyl fluoride (PMSF) from the newborn rat whole e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00427657
更新日期：1989-01-01 00:00:00
abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412706
更新日期：1979-05-29 00:00:00
abstract：:Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1494-2
更新日期：2014-11-01 00:00:00
abstract：:Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin de...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412738
更新日期：1990-01-01 00:00:00
abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1517-z
更新日期：2014-12-01 00:00:00
abstract：:The aim of this investigation was to determine whether volumetric changes occurred in differentiating layers of stratified squamous epithelium. Samples of cheek pouch mucosa from 5 hamsters were obtained, prepared for electron microscopy using carefully controlled methods, and electron micrographs obtained from define...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00409260
更新日期：1982-01-01 00:00:00
abstract：:The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1298-1
更新日期：2013-04-01 00:00:00
abstract：:Investigations on the nutrient requirements of Malassezia yeasts led to the preparation of a new minimal medium consisting of an amino nitrogen and a lipid source, which only allowed the growth of the species M. furfur. Carbohydrates, electrolytes, vitamins and trace elements were not required. Using the basal medium,...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050304
更新日期：1998-05-01 00:00:00
abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1606-7
更新日期：2016-01-01 00:00:00
abstract：:Solar ultraviolet (UV) irradiation causes damages on human skin and premature skin aging (photoaging). UV-induced reduction of type I collagen in dermis is widely considered primarily induction of wrinkled appearance of photoaging skin. Type I procollagen synthesis is reduced under UV irradiation by blocking transform...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0805-2
更新日期：2008-04-01 00:00:00
abstract：:Up to now, bicomponent keratohyalin has only been described for rat epithelium and human intraepidermal sweat ducts and fetal nail organ cells. In normal human interductal epidermis, the keratohyalin appears homogeneous, osmiophilic and stellate in shape. Under pathological conditions, bicomponent keratohyalin has bee...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00493461
更新日期：1990-01-01 00:00:00
abstract：:Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100239
更新日期：2001-07-01 00:00:00
abstract：:The penetration and permeation of the recombinant protein plasminogen activator inhibitor type 2 (PAI-2) in two formulations, one containing a penetration enhancer, into the psoriatic and uninvolved skin of eight patients with plaque-type psoriasis were investigated. Penetration and permeation of PAI-2 were measured b...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-003-0425-4
更新日期：2003-11-01 00:00:00
abstract：:The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00426583
更新日期：1989-01-01 00:00:00
abstract：:Serotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functiona...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0909-3
更新日期：2009-07-01 00:00:00
abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412495
更新日期：1985-01-01 00:00:00
abstract：:Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0938-6
更新日期：2009-04-01 00:00:00
abstract：:The goal of this study is to investigate commercially available cosmetics (foundations, skin care creams) which also claim to include a sun protection factor (SPF). Are these products, which are not considered sunscreen products, helpful or could they be harmful? Using an in vitro method, we tested the effectiveness o...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0974-2
更新日期：2009-09-01 00:00:00
abstract：:Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1053-4
更新日期：2010-10-01 00:00:00
abstract：:The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1719-2
更新日期：2017-04-01 00:00:00
abstract：:Patients with atopic dermatitis (AD) often present with dry skin, and the reduced secretion of sebum may be responsible for the impaired skin barrier function. A sebum check film enables the patient to self-evaluate the skin sebum content. This study compared the sebum check film with a sebumeter. The skin sebum conte...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1076-x
更新日期：2010-11-01 00:00:00
abstract：:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505240
更新日期：1996-07-01 00:00:00
abstract：:Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioim...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01106107
更新日期：1991-01-01 00:00:00
abstract：:Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1262-0
更新日期：2012-09-01 00:00:00
abstract：:The dermal papilla plays pivotal roles in hair follicle cycle and dermal papilla cells (DPCs) with aggregative behavior have more obviously inductive ability. In the present study, the suppression subtractive hybridization method was employed to identify the differentially expressed genes in dermal papillae cells with...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0583-7
更新日期：2005-09-01 00:00:00
abstract：:Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0645-5
更新日期：2006-07-01 00:00:00
abstract：:Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00408223
更新日期：1981-01-01 00:00:00
