Abstract：
:The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the basal layer of the epidermis in the HA and CCC model. Involucrin was obviously expressed in the upper layer of the epidermis in the HA and CCC model. Moreover, we observed that integrins α6 and β1 were strongly expressed along the basement membrane zone in the HA and CCC model, in which the dermis expressing type I collagen was more compact. In conclusion, our data indicate that CCC contributed to the formation of epidermis, basement membrane, and extracellular matrix in the reconstruction of SE and suggest that CCC may be a useful adjuvant in the reconstruction of SE.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Kim J,Jeong HS,Li H,Baek KJ,Kwon NS,Yun HY,Choi HR,Park KC,Kim DSdoi
10.1007/s00403-012-1283-8subject
Has Abstractpub_date
2013-01-01 00:00:00pages
85-89issue
1eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-012-1283-8journal_volume
305pub_type
杂志文章abstract：:The immigration of circulating T cells into specific tissues is directed by the interaction between adhesion molecules on lymphocyte subpopulations and their ligands on vascular endothelium. Of these, endothelial leucocyte adhesion molecule (ELAM-1), weakly expressed in normal human skin (NHS), seems to be the counter...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372006
更新日期：1993-01-01 00:00:00
abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373353
更新日期：1993-01-01 00:00:00
abstract：:IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02062-5
更新日期：2021-01-01 00:00:00
abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-016-1638-7
更新日期：2016-07-01 00:00:00
abstract：:Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioim...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01106107
更新日期：1991-01-01 00:00:00
abstract：:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cul...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00429985
更新日期：1988-01-01 00:00:00
abstract：:To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
abstract：:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1267-8
更新日期：2013-03-01 00:00:00
abstract：:To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1079-7
更新日期：2011-04-01 00:00:00
abstract：:Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01112911
更新日期：1993-01-01 00:00:00
abstract：:Marie Unna Hereditary Hypotrichosis 1 (MUHH1; OMIM 146550), a rare monogenic condition characterized by the development of sparse, twisted hair or complete hair loss, is the consequence of mutations located in the hairless (HR) gene. We have identified a 68-year-old Hungarian woman affected by alopecia universalis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1244-2
更新日期：2012-10-01 00:00:00
abstract：:Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against envoplakin and periplakin are almost always found. Epitope mapping has indicated that the linker subdomains of the proteins harbor the major antigenic sites recognized by PNP sera. In order to detect specific autoantib...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0901-y
更新日期：2009-10-01 00:00:00
abstract：:The incidence of cutaneous malignant melanoma continues to rise. Strategies to reduce mortality in this situation include improving therapy, encouraging earlier diagnosis, and promoting prevention. New developments such as epiluminescence, sentinel node biopsy, arterial limb perfusion and the use of vaccines are discu...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00370712
更新日期：1994-01-01 00:00:00
abstract：:A 61-year old woman developed a tumourous nodule in her left leg. Fifteen years ago a similar tumour had been removed in the same localization. Histological examination performed on biopsy material showed bundles of predominantly fusiform tumour cells with nuclear pleomorphism and many mitotic figures. Electron micros...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00446437
更新日期：1978-11-10 00:00:00
abstract：:In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373422
更新日期：1995-01-01 00:00:00
abstract：:Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacu...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694624
更新日期：1979-10-01 00:00:00
abstract：:Myotonic muscular dystrophy (MMD) is caused by an abnormal function of RNA-binding proteins (RBP) resulting in DNA spliceopathy. A case of a patient, with MMD multiple basal and squamous cell carcinomas and dysplastic nevi, is described. The association between MMD and non-melanoma skin cancer has been reported before...
journal_title：Archives of dermatological research
pub_type： 新闻
doi：10.1007/s00403-009-0997-8
更新日期：2010-04-01 00:00:00
abstract：:Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1828-6
更新日期：2018-07-01 00:00:00
abstract：:An increase in phosphodiesterase 4 (PDE4) in blood mononuclear white cells of patients with atopic dermatitis (AD) has been described. This and other skin disorders worsen during stress, during which there are increased circulating levels of adrenaline and glucocorticoids. The aim of this study was to analyse the effe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0313-3
更新日期：2002-07-01 00:00:00
abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412706
更新日期：1979-05-29 00:00:00
abstract：:Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosan-activated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin a produced an increased...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409454
更新日期：1981-01-01 00:00:00
abstract：:Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene en...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1762-z
更新日期：2017-10-01 00:00:00
abstract：:Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-r...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1218-4
更新日期：2012-03-01 00:00:00
abstract：:Painting of 3,3',4',5-tetrachlorosalicylanilide (TCSA) plus ultraviolet A (UVA) irradiation to the same site induces contact photosensitivity (CPS), but at the same time results in death of the photohapten-modified cells. Using an in vitro immune lymph node cell (LNC) proliferation system, we investigated the mechanis...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372063
更新日期：1991-01-01 00:00:00
abstract：:Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the P...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1711-2
更新日期：2017-04-01 00:00:00
abstract：:There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients witho...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1875-z
更新日期：2019-01-01 00:00:00
abstract：:The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0680-2
更新日期：2006-09-01 00:00:00
abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1863-3
更新日期：2018-11-01 00:00:00
abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0634-0
更新日期：2006-03-01 00:00:00
abstract：:Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-019-01972-3
更新日期：2020-03-01 00:00:00
