Cocarcinogenic and tumor-promoting capabilities of anthralin.

Abstract:

:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cultures that were previously exposed to a low dose of either benzo-a-pyrene (BaP), an indirect-acting carcinogen needing metabolic conversion for its carcinogenic action, or beta-propiolactone (BPL), a direct-acting carcinogen which needs no metabolic conversion. As a cocarcinogen, i.e., when exposure of cells to anthralin was simultaneous with exposure to the carcinogen, anthralin enhanced neoplastic transformation only when the carcinogen was BaP. Several explanations are explored. The possibility that cocarcinogens and tumor promotion occur by separate mechanisms is suggested.

journal_name

Arch Dermatol Res

authors

Baturay NZ,Trombetta LD

doi

10.1007/BF00429985

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

443-50

issue

7

eissn

0340-3696

issn

1432-069X

journal_volume

280

pub_type

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