Cocarcinogenic and tumor-promoting capabilities of anthralin.


:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cultures that were previously exposed to a low dose of either benzo-a-pyrene (BaP), an indirect-acting carcinogen needing metabolic conversion for its carcinogenic action, or beta-propiolactone (BPL), a direct-acting carcinogen which needs no metabolic conversion. As a cocarcinogen, i.e., when exposure of cells to anthralin was simultaneous with exposure to the carcinogen, anthralin enhanced neoplastic transformation only when the carcinogen was BaP. Several explanations are explored. The possibility that cocarcinogens and tumor promotion occur by separate mechanisms is suggested.


Arch Dermatol Res


Baturay NZ,Trombetta LD




Has Abstract


1988-01-01 00:00:00












  • Effects of different doses of abobotulinumtoxinA for the treatment of anterior gingival smile.

    abstract::Botulinum toxin type A (BoNT-A) is an easy and fast treatment for gingival smile (GS). The objective of the study was to compare the reduction of gingival exposure using three different doses of abobotulinumtoxinA (ABO) in patients with different severities of anterior GS, and to assess treatment safety and patients' ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Hexsel D,Dal'Forno T,Camozzato F,Valente I,Soirefmann M,Silva AF,Siega C

    更新日期:2020-07-28 00:00:00

  • Cryotherapy plus low-dose oral isotretinoin vs cryotherapy only for the treatment of anogenital warts: a randomized clinical trial.

    abstract:BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Reyna-Rodríguez IL,Chavez-Alvarez S,Garza-Rodríguez V,Franco-Marquez R,Gonzalez-Martinez G,Ocampo-Candiani J,Villarreal-Martinez A

    更新日期:2021-01-12 00:00:00

  • Plasma cluster ions decrease the antigenicity of mite allergens and suppress atopic dermatitis in NC/Nga mice.

    abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Hiramoto K,Orita K,Yamate Y,Sato EF,Okano H,Nishikawa K,Inoue M

    更新日期:2011-07-01 00:00:00

  • Mycosis fungoides associated with Mediterranean lymphoma.

    abstract::Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Cassuto JP,Kövary PM,Campagni JP,Simony J,Maiolini R,Schneider M

    更新日期:1981-01-01 00:00:00

  • Biological activities of dermatological interest by the water extract of the microalga Botryococcus braunii.

    abstract::The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Buono S,Langellotti AL,Martello A,Bimonte M,Tito A,Carola A,Apone F,Colucci G,Fogliano V

    更新日期:2012-11-01 00:00:00

  • Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: potential benefits for wound healing.

    abstract::Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Moura J,da Silva L,Cruz MT,Carvalho E

    更新日期:2013-09-01 00:00:00

  • Proliferative activity of cutaneous melanocytic neoplasms defined by a proliferating cell nuclear antigen labelling index.

    abstract::To evaluate the proliferative activity of benign, borderline and malignant cutaneous melanocytic neoplasms, 30 cases of malignant melanoma (MM) and 41 cases of naevi were studied by immunostaining using a monoclonal antibody against proliferating cell nuclear antigen (PCNA). PCNA is a nuclear antigen expressed in the ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tokuda Y,Mukai K,Matsuno Y,Furuya S,Shimosato Y,Takasaki Y,Saida T,Ishihara K

    更新日期:1992-01-01 00:00:00

  • Skin levels of vasoactive intestinal polypeptide in atopic dermatitis.

    abstract::Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioim...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Pincelli C,Fantini F,Romualdi P,Lesa G,Giannetti A

    更新日期:1991-01-01 00:00:00

  • MicroRNA in localized scleroderma: a review of literature.

    abstract::Localized scleroderma (LoSc) is rare connective tissue disease that manifests with inflammation and fibrosis of the skin. Depending on the LoSc subtype, adjacent structures such as subcutaneous tissue, fascia, muscles, bones may be affected. The hallmark of fibrosis is tissue remodelling with excess deposition of extr...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Wolska-Gawron K,Bartosińska J,Krasowska D

    更新日期:2020-07-01 00:00:00

  • Alterations in leukocyte aryl hydrocarbon hydroxylase activity associated with treatment and age in psoriasis patients and healthy individuals.

    abstract::We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Kraemer KH,Robinson RC,Tarone RE,Protic-Sabljic M,Gelboin HV

    更新日期:1984-01-01 00:00:00

  • Influence of certain ingredients on the SPF determined in vivo.

    abstract::When determined in vitro, the SPF of certain commercial sunscreen products can be lower than the SPF indicated on the label. The study of the composition of this type of product enabled us to note that the majority contained substances reputed to have anti-inflammatory properties. This effect is shown by inhibiting th...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Couteau C,Chauvet C,Paparis E,Coiffard LJ

    更新日期:2012-12-01 00:00:00

  • Prior exposure to dim light at night impairs dermal wound healing in female C57BL/6 mice.

    abstract::Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effect...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Walker WH 2nd,Meléndez-Fernández OH,Nelson RJ

    更新日期:2019-09-01 00:00:00

  • Sugars protect desmosome and corneosome glycoproteins from proteolysis.

    abstract::Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Walsh A,Chapman SJ

    更新日期:1991-01-01 00:00:00

  • Histopathogenesis of inflammatory linear verrucose epidermal naevus: histochemistry, immunohistochemistry and ultrastructure.

    abstract::Skin lesions of three patients with inflammatory linear verrucose epidermal naevus (ILVEN) were examined. Histologically, orthokeratosis and parakeratosis were alternately seen in the acanthotic epidermis. By N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide staining, the horny cells in the parakeratotic epidermis sh...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ito M,Shimizu N,Fujiwara H,Maruyama T,Tezuka M

    更新日期:1991-01-01 00:00:00

  • Opposite regulation of tyrosinase and glutathione peroxidase by intracellular thiols in human melanoma cells.

    abstract::Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Benathan M

    更新日期:1997-05-01 00:00:00

  • Adenylate cyclase system of human trichilemmoma cell line.

    abstract::The adenylate cyclase system of an established human trichilemmoma cell line was investigated. Stimulators of human epidermal adenylate cyclase system, epinephrine, histamine, adenosine, and prostaglandin E increased cyclic AMP levels of the trichilemmoma cells. The effects of epinephrine, histamine, and adenosine wer...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tsutsui M,Iizuka H,Ohkawara A,Adachi K,Kanzaki T

    更新日期:1987-01-01 00:00:00

  • A novel point mutation in type III collagen gene resulting in exon 24 skipping in a case of vascular type Ehlers-Danlos syndrome.

    abstract::A novel point mutation in a patient with vascular type Ehlers-Danlos syndrome is herein reported. The patient experienced pneumothorax and multiple arterial troubles during the past 10 years. The patient's hand skin was atrophic, and a paper-like atrophic scar was seen. The collagen microfibrils from the patient's ski...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Okamoto O,Ando T,Watanabe A,Sato F,Mimata H,Shimada T,Fujiwara S

    更新日期:2008-10-01 00:00:00

  • Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin.

    abstract::The immigration of circulating T cells into specific tissues is directed by the interaction between adhesion molecules on lymphocyte subpopulations and their ligands on vascular endothelium. Of these, endothelial leucocyte adhesion molecule (ELAM-1), weakly expressed in normal human skin (NHS), seems to be the counter...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Bos JD,de Boer OJ,Tibosch E,Das PK,Pals ST

    更新日期:1993-01-01 00:00:00

  • The relationship between severity of the disease and circulating nucleosomes in psoriasis patients.

    abstract::Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Dilek AR,Dilek N,Saral Y,Yüksel D

    更新日期:2013-08-01 00:00:00

  • A comparative study of oxidant-antioxidant status in stable and active vitiligo patients.

    abstract::The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ines D,Sonia B,Riadh BM,Amel el G,Slaheddine M,Hamida T,Hamadi A,Basma H

    更新日期:2006-09-01 00:00:00

  • The ultrastructure of congenital nevocytic nevi. I. Nevus cells in walls of blood vessels and lymphatics.

    abstract::As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schneider BV,Maie O

    更新日期:1985-01-01 00:00:00

  • Topical application of a first porphycene dye for photodynamic therapy--penetration studies in human perilesional skin and basal cell carcinoma.

    abstract::Photodynamic therapy (PDT) in dermatology has been proven to be a successful noninvasive therapeutic modality for treating skin cancer. To facilitate its clinical introduction, the development of topical photosensitizers is necessary to avoid generalized, cutaneous photosensitivity. Therefore the penetration of synthe...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Karrer S,Abels C,Szeimies RM,Bäumler W,Dellian M,Hohenleutner U,Goetz AE,Landthaler M

    更新日期:1997-02-01 00:00:00

  • Enhanced production and secretion of glial cell line-derived neurotrophic factor and nerve growth factor from the skin in atopic dermatitis mouse model.

    abstract::Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tokime K,Katoh-Semba R,Yamanaka K,Mizoguchi A,Mizutani H

    更新日期:2008-08-01 00:00:00

  • Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.

    abstract::Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: López-López N,González-Curiel I,Treviño-Santa Cruz MB,Rivas-Santiago B,Trujillo-Paez V,Enciso-Moreno JA,Serrano CJ

    更新日期:2014-11-01 00:00:00

  • Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with interferon alpha-2a combined with acitretin or PUVA.

    abstract::Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Rajan GP,Seifert B,Prümmer O,Joller-Jemelka HI,Burg G,Dummer R

    更新日期:1996-08-01 00:00:00

  • Evaluation of cutaneous algogenic responses to bradykinin and inhibition by bradykinin analogs.

    abstract::Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction blister bases. After determination of the pain threshold to bradykin...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schneider BK,Morelli JG,Vavrek RJ,Stewart JM,Weston WL

    更新日期:1992-01-01 00:00:00

  • UVA-induced tumours in pigmented hairless mice and the carcinogenic risks of tanning with UVA.

    abstract::An animal experiment is presented in which two groups of pigmented hairless mice were exposed daily to suberythemal doses of UVA to study tumourigenesis. The aim of the study was to estimate the carcinogenic risks of tanning by UVA. The pigmented hairless mice, Skh-hr2, were separated by selective breeding into two gr...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: van Weelden H,van der Putte SC,Toonstra J,van der Leun JC

    更新日期:1990-01-01 00:00:00

  • Why is polymorphous light eruption so common in young women?

    abstract::Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...

    journal_title:Archives of dermatological research

    pub_type: 信件


    authors: Aubin F

    更新日期:2004-10-01 00:00:00

  • Leprosy: diagnostic and control challenges for a worldwide disease.

    abstract::Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Goulart IM,Goulart LR

    更新日期:2008-07-01 00:00:00

  • UV-induced changes in urinary polyamine excretion in the mouse.

    abstract::Exposure of hairless mice to the light of a germicidal lamp (254 nm) under conditions which are known to induce epidermal DNA synthesis, cell proliferation, and polyamine metabolism produced a marked increase of polyamine excretion in the urine which lasted for many days. The increase was about the same for free and a...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Seiler N,Richards W,Knödgen B

    更新日期:1981-01-01 00:00:00