Cocarcinogenic and tumor-promoting capabilities of anthralin.


:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cultures that were previously exposed to a low dose of either benzo-a-pyrene (BaP), an indirect-acting carcinogen needing metabolic conversion for its carcinogenic action, or beta-propiolactone (BPL), a direct-acting carcinogen which needs no metabolic conversion. As a cocarcinogen, i.e., when exposure of cells to anthralin was simultaneous with exposure to the carcinogen, anthralin enhanced neoplastic transformation only when the carcinogen was BaP. Several explanations are explored. The possibility that cocarcinogens and tumor promotion occur by separate mechanisms is suggested.


Arch Dermatol Res


Baturay NZ,Trombetta LD




Has Abstract


1988-01-01 00:00:00












  • PCR analysis for Wolbachia in human and canine Demodex mites.

    abstract::In many skin diseases such as Demodex folliculitis, rosacea- or steroid-induced rosacea Demodex mites are present in abundance and are at least partially held responsible for causing these disorders. Although it is known that these diseases respond well to tetracyclines, it is unclear if this is due to the antiinflamm...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Borgo SN,Sattler EC,Hogardt M,Adler K,Plewig G

    更新日期:2009-10-01 00:00:00

  • Autoradiographic and planimetric analyses of the inflammatory infiltrate in psoriatic lesions under PUVA-therapy.

    abstract::The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Landthaler M,Plewig G,Hofmann C,Braun-Falco O

    更新日期:1980-01-01 00:00:00

  • Matrix metalloproteinase-2 promoter variability in psoriasis.

    abstract::The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity. In the total of 582 Czech Caucas...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Vasku V,Bienertova Vasku J,Slonková V,Kanková K,Vasku A

    更新日期:2009-07-01 00:00:00

  • Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria.

    abstract::The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HAN...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Bork K,Witzke G,Artmann K,Benes P,Böckers M,Kreuz W

    更新日期:1984-01-01 00:00:00

  • A specific ultrastructural marker for disseminated lipogranulomatosis (Faber).

    abstract::An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schmoeckel C,Hohlfed M

    更新日期:1979-10-01 00:00:00

  • Domain turnover of junctional membrane areas in the epidermis.

    abstract::To investigate the turnover of complete junctional membrane areas ("domain turnover"), psoriatic epidermis, keratoacanthoma, and squamous cell carcinoma were studied with an electron microscope and compared with the normal epidermis. Three types of domain turnover of junctions were observed. First, the uptake of intac...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Mahrle G

    更新日期:1982-01-01 00:00:00

  • Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis.

    abstract::Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Badertscher K,Brönnimann M,Karlen S,Braathen LR,Yawalkar N

    更新日期:2005-04-01 00:00:00

  • Histamine helps development of eczematous lesions in experimental contact dermatitis in mice.

    abstract::Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mic...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Seike M,Takata T,Ikeda M,Kodama H,Terui T,Ohtsu H

    更新日期:2005-08-01 00:00:00

  • Binding of autoantibodies is not restricted to desmosomes in pemphigus vulgaris: comparison of 14 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus studied by western immunoblot and immunoelectron microscopy.

    abstract::Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Bédane C,Prost C,Thomine E,Intrator L,Joly P,Caux F,Blecker M,Bernard P,Leboutet MJ,Tron F,Lauret P,Bonnetblanc JM,Dubertret L

    更新日期:1996-06-01 00:00:00

  • Cryofibrinogenemic purpura.

    abstract::A 50-year-old male patient had three episodes of acrally located purpura within 12 years without any other symptoms. The first two episodes which lasted several months coincided with the intake of beta-blockers; the third episode developed after a respiratory infection. A cryofibrinogenemia was found without any evide...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Brüngger A,Brülisauer M,Mitsuhashi Y,Schneider BV,Bollinger A,Schnyder UW

    更新日期:1987-01-01 00:00:00

  • Reversal of epidermal hyperproliferation in essential fatty acid deficient guinea pigs is accompanied by rapid generation of inositol triphosphate.

    abstract::This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed tha...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tang W,Ziboh VA

    更新日期:1988-01-01 00:00:00

  • Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis.

    abstract::Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clini...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schopf RE,Hoffmann A,Jung M,Morsches B,Bork K

    更新日期:1986-01-01 00:00:00

  • Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011.

    abstract::We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculat...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ong E,Goldacre R,Hoang U,Sinclair R,Goldacre M

    更新日期:2014-01-01 00:00:00

  • Epidermolytic palmoplantar keratoderma of Vörner: re-evaluation of Vörner's original family and identification of a novel keratin 9 mutation.

    abstract::In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen...

    journal_title:Archives of dermatological research

    pub_type: 历史文章,杂志文章


    authors: Küster W,Reis A,Hennies HC

    更新日期:2002-08-01 00:00:00

  • Effects of glycerol on human skin damaged by acute sodium lauryl sulphate treatment.

    abstract::Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing glycerol in relatively high amounts, preventing drawing conclusions from direct effects. In this study, acute che...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Atrux-Tallau N,Romagny C,Padois K,Denis A,Haftek M,Falson F,Pirot F,Maibach HI

    更新日期:2010-08-01 00:00:00

  • Pentane-1,5-diol as a percutaneous absorption enhancer.

    abstract::Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-bind...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Faergemann J,Wahlstrand B,Hedner T,Johnsson J,Neubert RH,Nyström L,Maibach H

    更新日期:2005-12-01 00:00:00

  • Stereographic analysis of syringomas.

    abstract::To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ito M,Yokoyama H,Ikeda K,Sato Y

    更新日期:1990-01-01 00:00:00

  • Enhanced production and secretion of glial cell line-derived neurotrophic factor and nerve growth factor from the skin in atopic dermatitis mouse model.

    abstract::Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tokime K,Katoh-Semba R,Yamanaka K,Mizoguchi A,Mizutani H

    更新日期:2008-08-01 00:00:00

  • [Histamine levels in interstitial fluid of lesional and perilesional skin in patients with chronic idiopathic urticaria (author's transl)].

    abstract::In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Bork K,König W,Böhm G

    更新日期:1979-11-01 00:00:00

  • [Reversible impairment of spermatogenesis induced by aromatic retinoid in guinea pigs (author's transl)].

    abstract::Forty-one male guinea pigs were treated orally with high doses of aromatic retinoid (Ro 10-9359) 25 mg/kg/day in oleum arachidis for 6 weeks. Twenty-three animals were investigated at the end of this treatment. The remaining 18 animals were investigated after an additional retinoid-free interval of 6 weeks. A control ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tsambaos D,Hundeiker M,Mahrle G,Orfanos CE

    更新日期:1980-01-01 00:00:00

  • Production of interferon and lymphoproliferative response in whole blood cultures derived from patients with atopic dermatitis.

    abstract::Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Kapp A,Gillitzer R,Kirchner H,Schöpf E

    更新日期:1987-01-01 00:00:00

  • GM-CSF downmodulates c-kit, Fc(epsilon)RI(alpha) and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells.

    abstract::GM-CSF is known primarily as a hematopoietic growth factor, but it has also been shown to inhibit mast cell differentiation in vitro. In order elucidate the mechanisms involved, we investigated the effects of GM-CSF in vitro on the differentiation of human leukemic mast cells (HMC-1 cells) and normal cord blood-derive...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Welker P,Grabbe J,Zuberbier T,Grützkau A,Henz BM

    更新日期:2001-05-01 00:00:00

  • Sex, constancy, and skin bacteria.

    abstract::Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Marples RR

    更新日期:1982-01-01 00:00:00

  • Quantitative analysis of alpha 1(I) and alpha 1(III) procollagen mRNA expression in systemic sclerosis skin tissue--an in situ hybridization study.

    abstract::Human alpha 1(I) and alpha 1(III) procollagen mRNA expression in skin tissue from 15 systemic sclerosis (SSc) patients and from 7 normal control subjects was quantitatively analyzed using in situ hybridization. The grains accumulating in each area, representing procollagen mRNA expression per cell, were counted. To no...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ohtsuka T,Koibuchi N,Sakai H,Yamakage A,Yamazaki S

    更新日期:1999-11-01 00:00:00

  • Detection of fumarate-glutathione adducts in the portal vein blood of rats: evidence for rapid dimethylfumarate metabolism.

    abstract::Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Dibbert S,Clement B,Skak-Nielsen T,Mrowietz U,Rostami-Yazdi M

    更新日期:2013-07-01 00:00:00

  • Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions.

    abstract::Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In th...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Vetter CS,Müller-Blech K,Schrama D,Bröcker EB,Becker JC

    更新日期:2005-07-01 00:00:00

  • Reporting regression with melanoma in situ: reappraisal of a potential paradox.

    abstract::Melanoma in situ (MIS) is a form of radial growth phase melanoma in which the proliferation of malignant cells is confined to the epidermis. Histologic features are invaluable in recognition of MIS. Regression occurs when the host's immune system attacks the primary melanocytic tumor cells via tumor infiltrate lymphoc...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Cartron AM,Aldana PC,Khachemoune A

    更新日期:2020-07-06 00:00:00

  • Suction blister fluid as a model for interstitial fluid in rats.

    abstract::1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Herfst MJ,van Rees H

    更新日期:1978-12-01 00:00:00

  • Interleukin-6 in psoriasis: expression and mitogenicity studies.

    abstract::Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Elder JT,Sartor CI,Boman DK,Benrazavi S,Fisher GJ,Pittelkow MR

    更新日期:1992-01-01 00:00:00

  • Cellular and nuclear volumetric alterations during differentiation of normal hamster cheek pouch epithelium.

    abstract::The aim of this investigation was to determine whether volumetric changes occurred in differentiating layers of stratified squamous epithelium. Samples of cheek pouch mucosa from 5 hamsters were obtained, prepared for electron microscopy using carefully controlled methods, and electron micrographs obtained from define...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: White FH,Gohari K

    更新日期:1982-01-01 00:00:00