Abstract:
:The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence of new lesions or their progression in the last 6 months, respectively. Eighteen patients with active vitiligo, 18 patients with stable vitiligo, and 40 controls were included in this study. We examined serum levels of malondialdehyde, selenium, vitamin E and A, and the erythrocyte activities of glutathione peroxidase, superoxide dismutase, and catalase. Our results revealed a significantly higher level of serum malondialdehyde, selenium in patients with active disease compared with the controls. Significant higher increase in erythrocytes superoxide dismutase activities was observed in active vitiligo group, erythrocyte glutathione peroxidase activity was decreased significantly in active disease, whereas erythrocyte catalase activity and plasma vitamin E and A levels were not different in vitiligo patients as compared with controls. Our study shows that oxidative stress is involved in the pathophysiology of both active and stable vitiligo but increased imbalance of antioxidants was observed in the blood of active vitiligo patients.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Ines D,Sonia B,Riadh BM,Amel el G,Slaheddine M,Hamida T,Hamadi A,Basma Hdoi
10.1007/s00403-006-0680-2subject
Has Abstractpub_date
2006-09-01 00:00:00pages
147-52issue
4eissn
0340-3696issn
1432-069Xjournal_volume
298pub_type
杂志文章abstract::Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1687-y
更新日期:2016-11-01 00:00:00
abstract::Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1340-y
更新日期:2013-08-01 00:00:00
abstract::Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050318
更新日期:1998-07-01 00:00:00
abstract::Investigations on the nutrient requirements of Malassezia yeasts led to the preparation of a new minimal medium consisting of an amino nitrogen and a lipid source, which only allowed the growth of the species M. furfur. Carbohydrates, electrolytes, vitamins and trace elements were not required. Using the basal medium,...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050304
更新日期:1998-05-01 00:00:00
abstract::Langerhans cells appear to be critical for IgE-mediated allergen capture and presentation in human atopic dermatitis. The present study sought to determine whether epidermal (i.e Langerhans cells) and dermal dendritic cells in the skin of dogs with atopic dermatitis are hyperplastic and expressed surface IgE. Frozen s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505260
更新日期:1996-09-01 00:00:00
abstract::Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1654-7
更新日期:2016-08-01 00:00:00
abstract::A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404624
更新日期:1984-01-01 00:00:00
abstract::Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in whic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0664-2
更新日期:2006-06-01 00:00:00
abstract::The authors report 2 cases of atypical vitiligo in which they observed 1) "cockade-like" lesions resembling those of "trichrome" vitiligo (from the centre to the periphery, achromic area, hypochromic ring, normal or hyperchromic border), 2) numerous linear achromic lesions corresponding to former excoriations (Koebner...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455391
更新日期:1978-07-28 00:00:00
abstract::The goal of this study is to investigate commercially available cosmetics (foundations, skin care creams) which also claim to include a sun protection factor (SPF). Are these products, which are not considered sunscreen products, helpful or could they be harmful? Using an in vitro method, we tested the effectiveness o...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0974-2
更新日期:2009-09-01 00:00:00
abstract::Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372034
更新日期:1992-01-01 00:00:00
abstract::Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0628-y
更新日期:2006-03-01 00:00:00
abstract::Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0856-z
更新日期:2008-08-01 00:00:00
abstract::Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. B. Grassi were invited to participate in the study (n = 395). Infor...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01911-2
更新日期:2019-07-01 00:00:00
abstract::This study concerns 57 patients who fulfilled histological criteria for the diagnosis allergic vasculitis. For 37 of these patients, biopsy specimen were available from lesional and adjacent non-lesional skin. Histological signs of vasculitis were found at both sites, but in clinically normal skin the perivascular inf...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00406538
更新日期:1980-01-01 00:00:00
abstract::Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412684
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to explore dermatologists' practices and attitudes related to educating and counseling their adolescent patients about indoor tanning. An online survey was carried out with a convenience sample of 100 dermatologists. Findings indicated that the majority of the dermatologists are actively enga...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-02026-4
更新日期:2020-11-01 00:00:00
abstract::About 5% of all cutaneous squamous cell carcinomas (cSCCs) metastasize, which is the principal cause of death by this type of cancer. However, to date there are no reliable biomarkers that categorize those SCC patients that will progress to metastasis. Nuclear active IKKα diminishes Maspin levels in prostate cancer fa...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1579-6
更新日期:2015-10-01 00:00:00
abstract::Tympanic (Tty), esophageal (Tes), forehead, and hand skin temperatures, as well as the forehead evaporation rate were recorded in six men (four suffering from rosacea and two healthy controls) before, during, and after 1 h of warm bath (38 degrees-39 degrees C). During the last 30 min of the bath, the subject's face w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424276
更新日期:1989-01-01 00:00:00
abstract::Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00408223
更新日期:1981-01-01 00:00:00
abstract::Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505252
更新日期:1996-08-01 00:00:00
abstract::Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1347-4
更新日期:2013-08-01 00:00:00
abstract::The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050218
更新日期:1997-07-01 00:00:00
abstract::Immigration of neutrophils into the epidermis is a hallmark of several so-called neutrophilic dermatoses. In this study we used a frozen section adhesion assay to study the impact of different activation procedures as well as of CD11 integrins on cell-cell adhesion between neutrophils and epidermal cells. Serial secti...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050263
更新日期:1997-11-01 00:00:00
abstract::Wound infections with multi-drug resistant bacteria increase morbidity and mortality and have considerable socioeconomic impact. They can lead to impaired wound healing, resulting in rising treatment costs. The aim of this study was to investigate an ex vivo human wound infection model. Human full-thickness skin from ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-1009-8
更新日期:2010-07-01 00:00:00
abstract::Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412622
更新日期:1987-01-01 00:00:00
abstract::HaCaT keratinocytes differ from normal human epidermal keratinocytes (HEK) by constitutive expression of differentiation markers which are normally suppressed by vitamin A. In search of an explanation for this discrepancy we compared the vitamin A content, the expression of retinoid-binding proteins, and the vitamin A...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050419
更新日期:1999-06-01 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-014-1480-8
更新日期:2014-12-01 00:00:00
abstract::Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0645-5
更新日期:2006-07-01 00:00:00
abstract::The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
doi:10.1007/s004030050231
更新日期:1997-08-01 00:00:00