Abstract:
:No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Psoriasis vulgaris (PsV) lesions were included as controls. Leakage of sweat and subsequent induction of chemokine expression were immunohistochemically identified. Both baseline and thermal stimulus-induced sweating responses were markedly impaired in LP lesions, as well as in PsV lesions. A marked difference, however, was found in normal-appearing perilesional skin; "cold spots", which were defined as a 1 mm2 area with no sweat droplets, were specifically and abundantly detected in perilesional LP skin, but not perilesional PsV skin. Leakage of sweat as evidenced by the immunohistochemical detection of dermcidin was specifically observed around the acrosyringium of these "cold spots" in LP, but not PsV, lesions and associated with CXCL10 induction on neighboring keratinocytes and syringotropic migration of CXCR3+ T cells. Leakage of sweat into the dermo-epidermal junction would serve not only to decrease sweat delivery to the skin surface but also to induce T-cell recruitment to the inflammatory site. Therapies for LP may be directed not only at ameliorating inflammatory responses but also at preventing the leakage of sweat into the dermo-epidermal junction.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Mizukawa Y,Yamazaki Y,Shiohara Tdoi
10.1007/s00403-018-1882-0subject
Has Abstractpub_date
2019-01-01 00:00:00pages
71-82issue
1eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-018-1882-0journal_volume
311pub_type
杂志文章abstract::A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404624
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abstract::In the study described here we investigated the possibility of an association between the aggressiveness of melanoma and multidrug resistance phenotype by analyzing the expression and activity of P-glycoprotein (Pgp) in two genetically related transplantable hamster melanomas--a melanotic (Ma) and an amelanotic (Ab) f...
journal_title:Archives of dermatological research
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abstract::The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...
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journal_title:Archives of dermatological research
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abstract::The prolongation of the S-phase, characteristic of psoriatic keratinocytes, can be observed in cells of the eccrine sweat glands as well as in those of the infundibular part of hair follicles. In healthy individuals the average duration of DNA-synthesis time (ts) in the cells of the hair follicle is 6.8 h, in unaffect...
journal_title:Archives of dermatological research
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abstract::Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...
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pub_type: 杂志文章
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abstract::Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...
journal_title:Archives of dermatological research
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更新日期:2012-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-014-1480-8
更新日期:2014-12-01 00:00:00
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abstract::Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0542-3
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abstract::A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated. All the 13 patients with keloids revealed in the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403728
更新日期:1982-01-01 00:00:00
abstract::Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505252
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abstract::Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030000160
更新日期:2000-09-01 00:00:00
abstract::Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with at...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
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更新日期:1980-01-01 00:00:00
abstract::Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determin...
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00402227
更新日期:1994-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0610-8
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abstract::Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1397-7
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abstract::In a previous study, impedance measurements and phoreographic response were shown to quantify significant differences between involved and non-involved skin in psoriasis. The same techniques were used to objectivate the evolution on skin condition on patients treated with dioxyanthranol, difluprednate, and photochemot...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412930
更新日期:1986-01-01 00:00:00
abstract::Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-008-0857-y
更新日期:2008-07-01 00:00:00
abstract::An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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