Abstract：
:Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Speeckaert R,Colebunders B,Boelaert JR,Brochez L,Van Acker J,Van Wanzeele F,Hemmer R,Speeckaert MM,Verhofstede C,De Buyzere M,Arendt V,Plum J,Delanghe JRdoi
10.1007/s00403-011-1161-9subject
Has Abstractpub_date
2011-12-01 00:00:00pages
763-9issue
10eissn
0340-3696issn
1432-069Xjournal_volume
303pub_type
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