Immunoadsorber for specific apheresis of autoantibodies in the treatment of bullous pemphigoid.


:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these antibodies should be a rational therapeutic approach. Here, we evaluated three recombinant forms of bacterially produced BP180 NC16A, a monomer, trimer, and tetramer, together with different matrices for their efficacy to specifically adsorb autoantibodies from BP plasma samples. An adsorber consisting of NC16A-trimer coupled to NHS-activated Sepharose 4 Fast Flow revealed satisfying adsorption rates and a high specificity. The NC16A-trimer adsorber was regenerable and autoclavable. It has the potential to be used for specific immunoadsorption to treat severe and refractory BP and other pemphigoid diseases associated with BP180 NC16A reactivity.


Arch Dermatol Res


Mersmann M,Dworschak J,Ebermann K,Komorowski L,Schlumberger W,Stöcker W,Zillikens D,Probst C,Schmidt E




Has Abstract


2016-01-01 00:00:00














  • Variations in percutaneous absorption of testosterone in the rhesus monkey due to anatomic site of application and frequency of application.

    abstract::This study determines if the anatomic region affected percutaneous absorption in the rhesus monkey, an animal model with some relevance to man. Percutaneous absorption of testosterone (13.3 microgram/cm2) from the ventral forearm was 8.8 +/- 2.5%. Absorption from the chest was slightly less (5.3 +/- 0.6%) while that f...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Wester RC,Noonan PK,Maibach HI

    更新日期:1980-01-01 00:00:00

  • Pathophysiology of cutaneous inflammation.

    abstract::For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Nickoloff BJ

    更新日期:1992-01-01 00:00:00

  • Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with interferon alpha-2a combined with acitretin or PUVA.

    abstract::Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Rajan GP,Seifert B,Prümmer O,Joller-Jemelka HI,Burg G,Dummer R

    更新日期:1996-08-01 00:00:00

  • Enhanced melanogenesis of murine melanoma cells cultured on or in collagen gel.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Kono T,Furukawa M,Tanii T,Mizuno N,Taniguchi S,Ishii M,Hamada T

    更新日期:1990-01-01 00:00:00

  • Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B1 receptor: functional relevance to angiogenesis.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Mejia AJ,Matus CE,Pavicic F,Concha M,Ehrenfeld P,Figueroa CD

    更新日期:2015-11-01 00:00:00

  • Suction blister fluid as a model for interstitial fluid in rats.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Herfst MJ,van Rees H

    更新日期:1978-12-01 00:00:00

  • The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Jave-Suárez LF,Schweizer J

    更新日期:2006-02-01 00:00:00

  • Identification of differentially expressed genes HSPC016 in dermal papilla cells with aggregative behavior.

    abstract::The dermal papilla plays pivotal roles in hair follicle cycle and dermal papilla cells (DPCs) with aggregative behavior have more obviously inductive ability. In the present study, the suppression subtractive hybridization method was employed to identify the differentially expressed genes in dermal papillae cells with...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Zhiqiang S,Jiwen W,Fei H,Weibin Y,Feng Z,Xichuan Y,Chunlan L

    更新日期:2005-09-01 00:00:00

  • Epidermolytic palmoplantar keratoderma of Vörner: re-evaluation of Vörner's original family and identification of a novel keratin 9 mutation.

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    journal_title:Archives of dermatological research

    pub_type: 历史文章,杂志文章


    authors: Küster W,Reis A,Hennies HC

    更新日期:2002-08-01 00:00:00

  • Mycobacterium ulcerans mycolactone interferes with adhesion, migration and proliferation of primary human keratinocytes and HaCaT cell line.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Graziola F,Colombo E,Tiberio R,Leigheb G,Bozzo C

    更新日期:2017-04-01 00:00:00

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ito M,Yokoyama H,Ikeda K,Sato Y

    更新日期:1990-01-01 00:00:00

  • Why vitiligo is associated with fewer risk of skin cancer?: providing a molecular mechanism.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Feily A,Pazyar N

    更新日期:2011-11-01 00:00:00

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    abstract::Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LB

    更新日期:2006-03-01 00:00:00

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Greiner JV,Glonek T,Townsend DJ,Hearn SL

    更新日期:1998-06-01 00:00:00

  • Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell carcinomas of the skin.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


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    更新日期:1989-01-01 00:00:00

  • The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Hessam S,Sand M,Skrygan M,Bechara FG

    更新日期:2017-09-01 00:00:00

  • The effects of topical corticosteroids on delayed pressure urticaria.

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    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1995-01-01 00:00:00

  • Extraction and quantitation of cytokine mRNA from human epidermal blister roofs.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


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    更新日期:1994-01-01 00:00:00

  • Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: González-López MA,Vilanova I,Ocejo-Viñals G,Arlegui R,Navarro I,Guiral S,Mata C,Pérez-Paredes MG,Portilla V,Corrales A,González-Vela MC,González-Gay MA,Blanco R,Hernández JL

    更新日期:2020-10-01 00:00:00

  • Opposing effects of UVA1 phototherapy on the expression of bcl-2 and p53 in atopic dermatitis.

    abstract::Recently, medium-dose UVA1 phototherapy (50 J/cm2) has been introduced as an effective treatment for severe atopic dermatitis (AD). In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement in skin status in patients with AD, biopsy specimens from ten patients before an...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Breuckmann F,Pieck C,Kreuter A,Bacharach-Buhles M,Mannherz HG,Altmeyer P,von Kobyletzki G

    更新日期:2001-04-01 00:00:00

  • Detection of fumarate-glutathione adducts in the portal vein blood of rats: evidence for rapid dimethylfumarate metabolism.

    abstract::Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Dibbert S,Clement B,Skak-Nielsen T,Mrowietz U,Rostami-Yazdi M

    更新日期:2013-07-01 00:00:00

  • Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis.

    abstract::It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Johansson O,Liang Y,Marcusson JA,Reimert CM

    更新日期:2000-08-01 00:00:00

  • A double blind trial of H1 and H2 receptor antagonists in the treatment of atopic dermatitis.

    abstract::Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...

    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frosch PJ,Schwanitz HJ,Macher E

    更新日期:1984-01-01 00:00:00

  • Papillomavirus DNA in warts of immunosuppressed renal allograft recipients.

    abstract::Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Gassenmaier A,Fuchs P,Schell H,Pfister H

    更新日期:1986-01-01 00:00:00

  • Epicardial fat thickness is ıncreased and associated with disease severity in hidradenitis suppurativa.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Alatas ET,Biteker M,Alatas OD

    更新日期:2020-09-01 00:00:00

  • PUVA therapy damages psoriatic and normal lymphoid cells within milliseconds.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Böhm F,Meffert H,Bauer E

    更新日期:1986-01-01 00:00:00

  • Circulating IgA- and IgG-class antigliadin antibodies in dermatitis herpetiformis detected by enzyme-linked immunosorbent assay.

    abstract::A sensitive and technically simple enzyme-linked immunosorbent assay (ELISA) was developed to demonstrate circulating IgA- and IgG-class antibodies to gliadin, a component of wheat gluten. Serum samples from 24 patients with dermatitis herpetiformis (DH), 5 with coeliac disease (CD) and 75 normal controls were analyse...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Vainio E,Kalimo K,Reunala T,Viander M,Palosuo T

    更新日期:1983-01-01 00:00:00

  • Ethnic differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Furukawa F,Muto M

    更新日期:2009-01-01 00:00:00

  • The polymorphisms of IL-6/STAT3 signaling pathway may contribute to cutaneous T-cell lymphomas susceptibility.

    abstract::IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Olszewska B,Gleń J,Zabłotna M,Nowicki RJ,Sokołowska-Wojdyło M

    更新日期:2021-01-01 00:00:00

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ines D,Sonia B,Riadh BM,Amel el G,Slaheddine M,Hamida T,Hamadi A,Basma H

    更新日期:2006-09-01 00:00:00