Immunoadsorber for specific apheresis of autoantibodies in the treatment of bullous pemphigoid.

Abstract:

:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these antibodies should be a rational therapeutic approach. Here, we evaluated three recombinant forms of bacterially produced BP180 NC16A, a monomer, trimer, and tetramer, together with different matrices for their efficacy to specifically adsorb autoantibodies from BP plasma samples. An adsorber consisting of NC16A-trimer coupled to NHS-activated Sepharose 4 Fast Flow revealed satisfying adsorption rates and a high specificity. The NC16A-trimer adsorber was regenerable and autoclavable. It has the potential to be used for specific immunoadsorption to treat severe and refractory BP and other pemphigoid diseases associated with BP180 NC16A reactivity.

journal_name

Arch Dermatol Res

authors

Mersmann M,Dworschak J,Ebermann K,Komorowski L,Schlumberger W,Stöcker W,Zillikens D,Probst C,Schmidt E

doi

10.1007/s00403-015-1606-7

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

31-8

issue

1

eissn

0340-3696

issn

1432-069X

pii

10.1007/s00403-015-1606-7

journal_volume

308

pub_type

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