Abstract:
:Koebner response was studied in 35 psoriatic patients. Two punch biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after, tape stripping. Alterations in the numbers of CD1+ Langerhans cells, CD4+ and CD8+ T cells and CD11c+ macrophages were mapped morphometrically. Results were compared with lesional and non-lesional psoriatic skin, and control skin. Nine of 35 patients were Koebner-positive. No statistically significant differences were noted between non-lesional psoriatic and control skin. CD4+ T cells increased in number 2 days after trauma in both the epidermis and the dermis, whereas epidermal CD8+ T cells and CD11c+ macrophages increased only in the Koebner-positive lesional skin after 7 days. The changes in lesions induced by tape-stripping resembled those seen in lesional psoriatic skin (mature plaques). The number of CD1+ cells increased in mature psoriatic lesions only. It seems possible that trauma per se stimulates the accumulation of CD4+ T cells at the site of injury, but the development of manifest psoriatic lesions correlates with invasion of CD8+ T cells and CD11c+ macrophages into the epidermis.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Paukkonen K,Naukkarinen A,Horsmanheimo Mdoi
10.1007/BF00372065keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
375-9issue
7eissn
0340-3696issn
1432-069Xjournal_volume
284pub_type
杂志文章abstract::Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-r...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1218-4
更新日期:2012-03-01 00:00:00
abstract::The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0680-2
更新日期:2006-09-01 00:00:00
abstract::Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0868-8
更新日期:2008-10-01 00:00:00
abstract::Staphylococcus aureus is a common wound-infecting organism which can interact with cells via the extracellular matrix protein fibronectin (FN). The aim of this study was to determine the effect of the FN-binding protein (FnBP) of S. aureus on the behaviour of a human skin keratinocytes cell line (UP). FN-coated plates...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0515-y
更新日期:2004-11-01 00:00:00
abstract::Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505821
更新日期:1996-03-01 00:00:00
abstract::Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1589-4
更新日期:2015-11-01 00:00:00
abstract::Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. M...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1753-0
更新日期:2017-09-01 00:00:00
abstract::An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424270
更新日期:1989-01-01 00:00:00
abstract::Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
abstract::Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1291-8
更新日期:2012-11-01 00:00:00
abstract::Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0747-8
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02182-y
更新日期:2021-01-12 00:00:00
abstract::Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0804-3
更新日期:2008-04-01 00:00:00
abstract::Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01982-1
更新日期:2020-03-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed in some papers, the mechanism of BCC pathogenesis is not fully understood. To the best of our knowledge, VEGF gene polymorphisms have ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1471-9
更新日期:2014-08-01 00:00:00
abstract::The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404455
更新日期:1980-01-01 00:00:00
abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1095-7
更新日期:2011-07-01 00:00:00
abstract::Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050195
更新日期:1997-04-01 00:00:00
abstract::The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0967-1
更新日期:2009-10-01 00:00:00
abstract::IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02062-5
更新日期:2021-01-01 00:00:00
abstract::Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased i...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509061
更新日期:1982-01-01 00:00:00
abstract::Two male patients with longstanding contact sensitivity to chromium were treated with PUVA. One patient, suffering from concomitant photosensitivity, reacted very favorably; his skin lesions cleared and light tolerance increased. This was paralleled by a decrease in the photopatch test reactivity and by the extinction...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403929
更新日期:1981-01-01 00:00:00
abstract::Murine mast cell proliferation and maturation are regulated by two distinct cytokines, interleukin-3 (IL-3) and the c-kit ligand, stem cell factor (SCF). In this study using cells of the mouse mast cell line, MC/9, the effects of two immunosuppressants, FK506 and cyclosporin A (CsA), were investigated. Withdrawal of I...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050408
更新日期:1999-05-01 00:00:00
abstract::There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients witho...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1875-z
更新日期:2019-01-01 00:00:00
abstract::The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1487-1
更新日期:2014-10-01 00:00:00
abstract::The effect of the proteolytic enzyme savinase on human plantar skin in vitro was examined by light and electron microscopy to elucidate the morphological involvement of activated savinase in human epidermis. Light microscopic examination of incubated skin fragments demonstrated that the histological changes produced b...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371819
更新日期:1991-01-01 00:00:00
abstract::The demonstration of cytokine mRNA expression in epidermal cells by the polymerase chain reaction technique preceded by reverse transcription (RT-PCR) requires linear test conditions (i.e. that the product obtained after amplification reflects the relative amounts of starting material) and high reproducibility, specif...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00370722
更新日期:1994-01-01 00:00:00
abstract::The pathomorphological and pathophysiological reactions of the first skincycle of the mutant (Ng) were histologically investigated. 1. During the hair growth disturbances as the result of imperfect keratinisation changes of the morphology and function of different skin areas could be observed. 2. The developments of a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455574
更新日期:1978-06-29 00:00:00
abstract::This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only sl...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00694617
更新日期:1979-10-01 00:00:00
abstract::Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01262328
更新日期:1995-01-01 00:00:00