Abstract:
:Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. Mild ER stress activates homeostatic UPR, while severe ER stress leads to abnormal UPR, promoting apoptosis and inflammation. Here, we investigated UV sensitivity and UVB-induced UPR in barrier-disrupted human skin and the effects of pseudoceramide-dominant emollient on UVB-induced skin responses. Tape-stripped skin of healthy volunteers showed enhanced susceptibility to erythema and augmented proinflammatory cytokines induction following suberythemal UVB irradiation. Suberythemal UVB activated XBP1 in normal skin, while increased CHOP transcription in barrier perturbed skin. After tape stripping, pseudoceramide-dominant emollient was applied for 3 days, and then, the areas were irradiated with suberythemal UVB. Pretreatment with topical pseudoceramide protected against UVB-induced upregulation of IL-1β, IL-6, and TNF-α transcription and reduced susceptibility to erythema following UVB. Topical pseudoceramide also suppressed suberythemal UVB-induced CHOP transcription in barrier-disrupted skin. Taken together, these data indicate that permeability barrier disruption increases UV sensitivity in human skin, partly via switch the UVB-induced UPR, from homeostatic signals to pro-apoptotic and proinflammatory signals. In addition, we conclude that pseudoceramide-dominant emollient suppresses excessive ER stress induction and CHOP activation following UVB in barrier damaged skin, providing evidence that pseudoceramide-dominant emollients can be promising strategies for photoprotection of the barrier damaged skin.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Lee SE,Takagi Y,Nishizaka T,Baek JH,Kim HJ,Lee SHdoi
10.1007/s00403-017-1753-0subject
Has Abstractpub_date
2017-09-01 00:00:00pages
541-550issue
7eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-017-1753-0journal_volume
309pub_type
杂志文章abstract::The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system's response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1760-1
更新日期:2017-09-01 00:00:00
abstract::Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/pl00007450
更新日期:1998-07-01 00:00:00
abstract::Previous studies have demonstrated that permeability barrier disruption by acetone treatment significantly enhances skin permeability to both hydrophilic and amphipathic compounds, but not to highly lipophilic compounds. The purpose of the present study was to investigate the dependence of permeability on molecular we...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030100229
更新日期:2001-06-01 00:00:00
abstract::The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00493466
更新日期:1990-01-01 00:00:00
abstract::A sensitive and technically simple enzyme-linked immunosorbent assay (ELISA) was developed to demonstrate circulating IgA- and IgG-class antibodies to gliadin, a component of wheat gluten. Serum samples from 24 patients with dermatitis herpetiformis (DH), 5 with coeliac disease (CD) and 75 normal controls were analyse...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00516548
更新日期:1983-01-01 00:00:00
abstract::Primary cultures of guinea pig ear keratinocytes were treated with vitamin A acid at plating, or at 14 h or 14 days after plating. The intracellular content of the cyclic nucleotides cAMP and cGMP was determined by radioimmunoassay at intervals during a period of 50 h after treatment. When added at plating, vitamin A ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00416918
更新日期:1980-01-01 00:00:00
abstract::The exposure of naked unprotected skin to solar radiation may result in numerous acute and chronic undesirable effects. Evidence suggests that silymarin, a standardized extract from Silybum marianum (L.) Gaertn. seeds, and its major component silybin suppress UVB-induced skin damage. Here, we aimed to investigate the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01928-7
更新日期:2019-08-01 00:00:00
abstract::Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clini...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417528
更新日期:1986-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) can infect epithelial cells as well as B lymphocytes. Infection of the male and female genital tracts has recently been demonstrated, and it has been suggested that the virus may be sexually transmissible. In our study we investigated whether EBV can be found in the anal region of sexually act...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00374084
更新日期:1995-01-01 00:00:00
abstract::Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatmen...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1791-7
更新日期:2018-01-01 00:00:00
abstract::The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0967-1
更新日期:2009-10-01 00:00:00
abstract::Programmed cell death protein-1 (PD-1) is primarily recognized as an inhibitory receptor involved in the regulation of immunological tolerance. However, recent studies have indicated that PD-1/PD-L1 signaling could also regulate the functions of nonimmune cells and may be involved in regulating hair biology. In this s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-020-02169-9
更新日期:2021-01-05 00:00:00
abstract::Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in whic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0664-2
更新日期:2006-06-01 00:00:00
abstract::A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505240
更新日期:1996-07-01 00:00:00
abstract::Localized scleroderma (LoSc) is rare connective tissue disease that manifests with inflammation and fibrosis of the skin. Depending on the LoSc subtype, adjacent structures such as subcutaneous tissue, fascia, muscles, bones may be affected. The hallmark of fibrosis is tissue remodelling with excess deposition of extr...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-019-01991-0
更新日期:2020-07-01 00:00:00
abstract::To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1079-7
更新日期:2011-04-01 00:00:00
abstract::The treatment of epidermolysis bullosa acquisita (EBA) is difficult and often disappointing. We report on the successful treatment of two EBA patients with colchicine. The drug was administered orally at an initial dose of 2 mg/day. After 2 weeks of therapy a dramatic improvement was observed. Most of the cutaneous an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00375841
更新日期:1994-01-01 00:00:00
abstract::As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412496
更新日期:1985-01-01 00:00:00
abstract::We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0863-0
更新日期:2008-07-01 00:00:00
abstract::Eleven dysplastic melanocytic naevi with various degrees of dysplasia, as judged by light microscopy, were studied by transmission electron microscopy, and their intra-epidermal melanocytes compared with those of five superficial spreading melanomas and seven common benign naevocellular naevi. Intra-epidermal melanocy...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372084
更新日期:1990-01-01 00:00:00
abstract::The adenylate cyclase system of an established human trichilemmoma cell line was investigated. Stimulators of human epidermal adenylate cyclase system, epinephrine, histamine, adenosine, and prostaglandin E increased cyclic AMP levels of the trichilemmoma cells. The effects of epinephrine, histamine, and adenosine wer...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00413285
更新日期:1987-01-01 00:00:00
abstract::Recent evidence indicates that the biologically active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], has an effect on the regulation of the immune response. We investigated whether topical treatment of mice with 1 alpha,25(OH)2D3 influences the contact hypersensitivity (CHS) response to...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412982
更新日期:1989-01-01 00:00:00
abstract::Wnt pathway plays an important role in controlling metabolism in cancer cells. It acts as positive modulator for both cell inflammation, through activation of NFκB, and fibrosis, through activation of TGF-β. Therefore, the aim of this study is to investigate the therapeutic effects of blocking Wnt pathway by IWP12 on ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01939-4
更新日期:2019-10-01 00:00:00
abstract::Scleroderma is a heterogeneous disease with a complex etiology. As more information is gained about the underlying mechanisms and the improved classifications of scleroderma subtypes, treatments can be better personalized. Improving scleroderma patients' early diagnosis before end organ manifestations occur should imp...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-016-1647-6
更新日期:2016-09-01 00:00:00
abstract::Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0542-3
更新日期:2005-04-01 00:00:00
abstract::Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1687-y
更新日期:2016-11-01 00:00:00
abstract::In this study we investigated the influence of keratinocytes on the phenotype of fibroblasts in an in vitro human skin equivalent. Keratinocytes were seeded at the surface of fibroblast-populated mechanically restrained type I collagen gels (lattices). Lattices without keratinocytes were handled in parallel as control...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371739
更新日期:1995-01-01 00:00:00
abstract::Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1347-4
更新日期:2013-08-01 00:00:00
abstract::Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1262-0
更新日期:2012-09-01 00:00:00
abstract::The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509237
更新日期:1985-01-01 00:00:00