Abstract:
:Previous studies showed an association between various dermatological diseases and epicardial fat thickness (EFT). However, EFT, which has been accepted as a cardiometabolic risk factor in recent years, has not been studied in the context of hidradenitis suppurativa (HS). Therefore, we aimed to determine whether EFT is increased in HS patients, and whether EFT is associated with disease severity. Forty adult patients with HS and 100 age- and sex-matched controls were included. Patients with diabetes mellitus, cardiovascular diseases, chronic renal or hepatic diseases, or other inflammatory conditions were excluded. The EFT was measured by transthoracic echocardiography. Disease severity was assessed by Hurley stage, and stage III patients have been described as having severe disease. High-sensitivity C-reactive protein (hs-CRP) and EFT were significantly higher in HS patients compared to controls. There were positive correlations between EFT and the duration of the disease, hs-CRP, and Hurley stage. The EFT was proportionally increased in HS patients with increasing disease severity; the largest EFT was found in Hurley stage 3 patients (7.34 ± 2.30 mm), followed by Hurley stage 2 patients (6.12 ± 1.82 mm), and Hurley stage 1 patients (4.83 ± 0.98 mm). Multivariate analysis showed that male gender, hs-CRP, body mass index, and EFT ≥ 5.9 mm were independent predictors of severe disease. The EFT is increased in HS, and it is an independent predictor of disease severity in adult patients with HS.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Alatas ET,Biteker M,Alatas ODdoi
10.1007/s00403-019-02032-6subject
Has Abstractpub_date
2020-09-01 00:00:00pages
467-472issue
7eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-019-02032-6journal_volume
312pub_type
杂志文章abstract::The established mouse epidermis-derived cell line HEL/30 was incubated in the presence of 3H arachidonic acid (AA) for 1 h. After medium removal, cells were reincubated with fresh medium in the presence or absence of the calcium ionophore A23187 and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The AA me...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00429984
更新日期:1988-01-01 00:00:00
abstract::Painting of 3,3',4',5-tetrachlorosalicylanilide (TCSA) plus ultraviolet A (UVA) irradiation to the same site induces contact photosensitivity (CPS), but at the same time results in death of the photohapten-modified cells. Using an in vitro immune lymph node cell (LNC) proliferation system, we investigated the mechanis...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372063
更新日期:1991-01-01 00:00:00
abstract::The exposure of naked unprotected skin to solar radiation may result in numerous acute and chronic undesirable effects. Evidence suggests that silymarin, a standardized extract from Silybum marianum (L.) Gaertn. seeds, and its major component silybin suppress UVB-induced skin damage. Here, we aimed to investigate the ...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-019-01928-7
更新日期:2019-08-01 00:00:00
abstract::It has been reported that artificial restoration of barrier function by a water vapor-impermeable membrane after tape stripping induces barrier abrogation in hairless mice, impeding rather than enhancing barrier recovery. To address this issue, we examined the morphologic changes in the epidermis after tape stripping ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050280
更新日期:1998-03-01 00:00:00
abstract::In the present study, attempts were made to clarify the role of an elastase-like enzyme in Arthus reaction by using rabbit-peritoneal polymorphonuclear leukocytes (PMNs). It was first confirmed that the injection of large amounts of PMNs with antibody can increase tissue damage in reversed Arthus reaction. The five va...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00413357
更新日期:1984-01-01 00:00:00
abstract::Primary cultures of guinea pig ear keratinocytes were treated with vitamin A acid at plating, or at 14 h or 14 days after plating. The intracellular content of the cyclic nucleotides cAMP and cGMP was determined by radioimmunoassay at intervals during a period of 50 h after treatment. When added at plating, vitamin A ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00416918
更新日期:1980-01-01 00:00:00
abstract::The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1978-09-28 00:00:00
abstract::No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1882-0
更新日期:2019-01-01 00:00:00
abstract::The incidence of cutaneous malignant melanoma continues to rise. Strategies to reduce mortality in this situation include improving therapy, encouraging earlier diagnosis, and promoting prevention. New developments such as epiluminescence, sentinel node biopsy, arterial limb perfusion and the use of vaccines are discu...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/BF00370712
更新日期:1994-01-01 00:00:00
abstract::Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00409265
更新日期:1982-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00426614
更新日期:1988-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404286
更新日期:1980-01-01 00:00:00
abstract::Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050444
更新日期:1999-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0967-1
更新日期:2009-10-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1791-7
更新日期:2018-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0809-y
更新日期:2008-01-01 00:00:00
abstract::Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00511060
更新日期:1984-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505222
更新日期:1996-04-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1267-8
更新日期:2013-03-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372709
更新日期:1992-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404284
更新日期:1980-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-002-0381-4
更新日期:2003-03-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0884-8
更新日期:2008-10-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,随机对照试验
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更新日期:2006-06-01 00:00:00
abstract::Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585916
更新日期:1987-01-01 00:00:00
abstract::Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene thera...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0653-5
更新日期:2006-06-01 00:00:00
abstract::In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00373422
更新日期:1995-01-01 00:00:00