Abstract:
:We previously showed that the homeodomain protein HOXC13 is involved in the expression control of the early human hair keratin genes hHa5 and hHa2, which contain specific HOXC13 binding sites in their proximal promoters. Hox specificity is generally thought to be enhanced by the interaction with members of the TALE superclass of homeodomain proteins Pbx, Meis, and Prep. Using reverse transcription PCR with total human hair follicle RNA, we demonstrated transcripts of the major TALE proteins PBX1-4, MEIS1, 2 and PREP1, 2 in the human hair follicle. In view of the presence of MEIS/PREP responsive elements in close vicinity to the HOXC13 binding sites of the hHa5 and hHa2 promoters, we determined the expression sites of these TALE proteins in the human hair follicle. We found that MEIS1, MEIS2, PREP1 and PREP2 were differentially expressed in the three layers of the inner root sheath. In addition, MEIS2 and PREP1 exhibited expression in the mid-to upper hair cortex, with PREP1 being also expressed in the dermal papilla and the connective tissue sheath of the hair follicle. In virtually all cases, the expression of these TALE proteins was exclusively cytoplasmic. Considering that in contrast, HOXC13 is expressed in the nuclei of matrix, precortex and lower cuticle cells of the hair follicle, our data suggest that despite the presence of MEIS/PREP binding sites in the hHa5 and hHa2 promoters, the HOXC13-controlled activation of these genes in the hair follicle does not seem to involve these TALE proteins as cofactors.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Jave-Suárez LF,Schweizer Jdoi
10.1007/s00403-005-0623-3keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
372-6issue
8eissn
0340-3696issn
1432-069Xjournal_volume
297pub_type
杂志文章abstract::An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424270
更新日期:1989-01-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-013-1381-2
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abstract::Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two pa...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1606-7
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journal_title:Archives of dermatological research
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doi:10.1007/BF00440602
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0653-5
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02507101
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/BF00370712
更新日期:1994-01-01 00:00:00
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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doi:10.1007/s00403-015-1595-6
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abstract::Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050449
更新日期:1999-10-01 00:00:00
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371798
更新日期:1994-01-01 00:00:00
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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doi:
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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doi:10.1007/s004030050359
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pub_type: 临床试验,杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Archives of dermatological research
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