Abstract:
:Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two parameters were evaluated at 44 degrees C (temperature of the two sensors) in 13 patients and 13 controls, and at 36-37 degrees C in the remaining 11. At 44 degrees C, TcPO2 was lower in SSc patients than in controls for both sclerotic and non-sclerotic skin. At 37 degrees C there was no significant difference. At 44 degrees C, LD values were decreased in patients with respect to controls for both sclerotic and and non-sclerotic skin. In contrast, at 37 degrees C the values were increased in patients only for the sclerotic skin. It can be hypothesized that the increased LD values at physiological temperature are at least in part balancing a decreased tissue oxygen tension, then a normal TcPO2 is ensured. On the other hand, the decreased LD values at 44 degrees C, when TcPO2 is also decreased, indicates that there is an inability of SSc vessels to significantly increase their flow under the stimulus of a maximal hyperaemia-inducing temperature.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Valentini G,Leonardo G,Moles DA,Apaia MR,Maselli R,Tirri G,Del Guercio Rdoi
10.1007/BF00376614subject
Has Abstractpub_date
1991-01-01 00:00:00pages
285-8issue
5eissn
0340-3696issn
1432-069Xjournal_volume
283pub_type
杂志文章abstract::Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00408223
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00418573
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00406415
更新日期:1980-01-01 00:00:00
abstract::Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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pub_type: 杂志文章
doi:10.1007/BF01105793
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01105076
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585916
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00424270
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