Transcutaneous oxygen pressure in systemic sclerosis: evaluation at different sensor temperatures and relationship to skin perfusion.

Abstract:

:Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two parameters were evaluated at 44 degrees C (temperature of the two sensors) in 13 patients and 13 controls, and at 36-37 degrees C in the remaining 11. At 44 degrees C, TcPO2 was lower in SSc patients than in controls for both sclerotic and non-sclerotic skin. At 37 degrees C there was no significant difference. At 44 degrees C, LD values were decreased in patients with respect to controls for both sclerotic and and non-sclerotic skin. In contrast, at 37 degrees C the values were increased in patients only for the sclerotic skin. It can be hypothesized that the increased LD values at physiological temperature are at least in part balancing a decreased tissue oxygen tension, then a normal TcPO2 is ensured. On the other hand, the decreased LD values at 44 degrees C, when TcPO2 is also decreased, indicates that there is an inability of SSc vessels to significantly increase their flow under the stimulus of a maximal hyperaemia-inducing temperature.

journal_name

Arch Dermatol Res

authors

Valentini G,Leonardo G,Moles DA,Apaia MR,Maselli R,Tirri G,Del Guercio R

doi

10.1007/BF00376614

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

285-8

issue

5

eissn

0340-3696

issn

1432-069X

journal_volume

283

pub_type

杂志文章
  • PUVA therapy damages psoriatic and normal lymphoid cells within milliseconds.

    abstract::Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00404352

    authors: Böhm F,Meffert H,Bauer E

    更新日期:1986-01-01 00:00:00

  • Expression of plectin and HD1 epitopes in patients with epidermolysis bullosa simplex associated with muscular dystrophy.

    abstract::Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s004030050449

    authors: Shimizu H,Masunaga T,Kurihara Y,Owaribe K,Wiche G,Pulkkinen L,Uitto J,Nishikawa T

    更新日期:1999-10-01 00:00:00

  • Plasma cluster ions decrease the antigenicity of mite allergens and suppress atopic dermatitis in NC/Nga mice.

    abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-010-1095-7

    authors: Hiramoto K,Orita K,Yamate Y,Sato EF,Okano H,Nishikawa K,Inoue M

    更新日期:2011-07-01 00:00:00

  • Anti-tumor effect of PDT using Photofrin in a mouse angiosarcoma model.

    abstract::Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-007-0820-3

    authors: Jin I,Yuji M,Yoshinori N,Makoto K,Mikio M

    更新日期:2008-04-01 00:00:00

  • [Correlation of growth hormone and aetiology of psoriasis].

    abstract::Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00408223

    authors: Weber G,Neidhardt M,Schmidt A,Geiger A

    更新日期:1981-01-01 00:00:00

  • Variations in percutaneous absorption of testosterone in the rhesus monkey due to anatomic site of application and frequency of application.

    abstract::This study determines if the anatomic region affected percutaneous absorption in the rhesus monkey, an animal model with some relevance to man. Percutaneous absorption of testosterone (13.3 microgram/cm2) from the ventral forearm was 8.8 +/- 2.5%. Absorption from the chest was slightly less (5.3 +/- 0.6%) while that f...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00403844

    authors: Wester RC,Noonan PK,Maibach HI

    更新日期:1980-01-01 00:00:00

  • The quantitative distribution of percutaneously applied caffeine in the human skin.

    abstract::The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00418573

    authors: Zesch A,Schaefer H,Stüttgen G

    更新日期:1979-11-01 00:00:00

  • Mechanical properties and Young's modulus of human skin in vivo.

    abstract::The mechanical properties of the in vivo dermis were measured by means of a torque applied to the skin. The resulting deformation of 2-6 degrees, including the immediate and delayed visco-elastic components, as well as the relaxation were measured, and the raw values corrected for a constant skin thickness. The experi...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00406415

    authors: Agache PG,Monneur C,Leveque JL,De Rigal J

    更新日期:1980-01-01 00:00:00

  • Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.

    abstract::Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-014-1494-2

    authors: López-López N,González-Curiel I,Treviño-Santa Cruz MB,Rivas-Santiago B,Trujillo-Paez V,Enciso-Moreno JA,Serrano CJ

    更新日期:2014-11-01 00:00:00

  • Effects of different doses of abobotulinumtoxinA for the treatment of anterior gingival smile.

    abstract::Botulinum toxin type A (BoNT-A) is an easy and fast treatment for gingival smile (GS). The objective of the study was to compare the reduction of gingival exposure using three different doses of abobotulinumtoxinA (ABO) in patients with different severities of anterior GS, and to assess treatment safety and patients' ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-020-02096-9

    authors: Hexsel D,Dal'Forno T,Camozzato F,Valente I,Soirefmann M,Silva AF,Siega C

    更新日期:2020-07-28 00:00:00

  • Willingness to pay and quality of life in patients with atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and quality of life (Qol) in AD patients and (2) to compare the results with data on other chronic skin diseases. To collect data, a non-interventional, cross-sectional nationwide p...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-013-1402-1

    authors: Beikert FC,Langenbruch AK,Radtke MA,Kornek T,Purwins S,Augustin M

    更新日期:2014-04-01 00:00:00

  • Sex, constancy, and skin bacteria.

    abstract::Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00509062

    authors: Marples RR

    更新日期:1982-01-01 00:00:00

  • Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients.

    abstract::Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-011-1161-9

    authors: Speeckaert R,Colebunders B,Boelaert JR,Brochez L,Van Acker J,Van Wanzeele F,Hemmer R,Speeckaert MM,Verhofstede C,De Buyzere M,Arendt V,Plum J,Delanghe JR

    更新日期:2011-12-01 00:00:00

  • Tranilast inhibits the cell growth of normal human keratinocytes in vitro.

    abstract::Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-012-1291-8

    authors: Kubo M,Zhao Y,Moriguchi T

    更新日期:2012-11-01 00:00:00

  • The expression of interleukin-8 receptor in untreated and treated psoriasis.

    abstract::The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s004030050218

    authors: Beljaards RC,Van Beek P,Nieboer C,Stoof TJ,Boorsma DM

    更新日期:1997-07-01 00:00:00

  • Altered distribution of keratinization markers in epidermolytic hyperkeratosis.

    abstract::Epidermolytic hyperkeratosis (EH) is a genetic disorder of keratins associated with epidermal differentiation. Affected individuals carry gene mutations for conserved sequences of keratins K1 or K10. The structural alterations of tonofilaments in EH seem to be a direct consequence of the keratin gene mutations. EH epi...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF01105793

    authors: Ishida-Yamamoto A,Iizuka H,Manabe M,O'Guin WM,Hohl D,Kartasova T,Kuroki T,Roop DR,Eady RA

    更新日期:1995-01-01 00:00:00

  • Tumour necrosis factors and several interleukins inhibit the growth and modulate the antigen expression of normal human melanocytes in vitro.

    abstract::In the present study the action of various cytokines as regulators of human melanocyte growth and differentiation was examined in vitro. Primary melanocyte cultures were obtained in complete medium free of 12-O-tetradecanoylphorbol-13-acetate or serum. First passage melanocytes were treated with various concentrations...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF01105076

    authors: Krasagakis K,Garbe C,Eberle J,Orfanos CE

    更新日期:1995-01-01 00:00:00

  • Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms.

    abstract::The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subject...

    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s00403-004-0465-4

    authors: Harrison LI,Skinner SL,Marbury TC,Owens ML,Kurup S,McKane S,Greene RJ

    更新日期:2004-06-01 00:00:00

  • Both Th1 and Th2 chemokines are elevated in sera of patients with autoimmune blistering diseases.

    abstract::Although chemokines are critical elements for the selective attraction and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning T helper (Th) 1 or Th2 chemokines in autoimmune blistering disease (ABD). To determine whether serum levels of chemokines that are preferenti...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-006-0661-5

    authors: Echigo T,Hasegawa M,Shimada Y,Inaoki M,Takehara K,Sato S

    更新日期:2006-06-01 00:00:00

  • Epidermal and dermal phospholipids of the human eyelid: a 31P nuclear magnetic resonance spectroscopy study.

    abstract::The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s004030050308

    authors: Greiner JV,Glonek T,Townsend DJ,Hearn SL

    更新日期:1998-06-01 00:00:00

  • Co-culture of human fibroblasts and Borrelia burgdorferi enhances collagen and growth factor mRNA.

    abstract::Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determin...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-017-1797-1

    authors: Aberer E,Surtov-Pudar M,Wilfinger D,Deutsch A,Leitinger G,Schaider H

    更新日期:2018-03-01 00:00:00

  • Circulating IgA- and IgG-class antigliadin antibodies in dermatitis herpetiformis detected by enzyme-linked immunosorbent assay.

    abstract::A sensitive and technically simple enzyme-linked immunosorbent assay (ELISA) was developed to demonstrate circulating IgA- and IgG-class antibodies to gliadin, a component of wheat gluten. Serum samples from 24 patients with dermatitis herpetiformis (DH), 5 with coeliac disease (CD) and 75 normal controls were analyse...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00516548

    authors: Vainio E,Kalimo K,Reunala T,Viander M,Palosuo T

    更新日期:1983-01-01 00:00:00

  • A family study of atopic dermatitis. Clinical and genetic characteristics of 188 patients and 2,151 family members.

    abstract::The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00493466

    authors: Küster W,Petersen M,Christophers E,Goos M,Sterry W

    更新日期:1990-01-01 00:00:00

  • Effect of RNA interference of tight junction-related molecules on intercellular barrier function in cultured human keratinocytes.

    abstract::Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-008-0868-8

    authors: Yamamoto T,Saeki Y,Kurasawa M,Kuroda S,Arase S,Sasaki H

    更新日期:2008-10-01 00:00:00

  • Effects of Gadodiamide on cell proliferation and collagen production in cultured human dermal fibroblasts.

    abstract::Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-016-1689-9

    authors: Ozawa Y,Hayashi S,Hamasaki Y,Hatamochi A

    更新日期:2016-12-01 00:00:00

  • Stratum corneum swelling. Biophysical and computer assisted quantitative assessments.

    abstract::The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...

    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004030050231

    authors: Norlén L,Emilson A,Forslind B

    更新日期:1997-08-01 00:00:00

  • Protective effect of trimethylpsoralen against UV-B erythema.

    abstract::Vitiliginous patients undergoing photochemotherapy with TMP were less susceptible to a sun burn. To investigate this point, the MED for UV-B was measured before, 2 h, and 24 h after oral intake of TMP in 10 healthy volunteers. There was an increase of MED when UV exposure had taken place 2 h after TMP intake (P < 0.01...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00403890

    authors: Agache PG,Coupez L

    更新日期:1980-01-01 00:00:00

  • Malondialdehyde, lipoprotein-a, lipoprotein ratios, comprehensive lipid tetrad index and atherogenic index as surrogate markers for cardiovascular disease in patients with psoriasis: a case-control study.

    abstract::Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/s00403-019-01896-y

    authors: Wadhwa D,Mahajan VK,Mehta KS,Chauhan PS,Yadav RS,Bhushan S,Sharma V,Sharma A,Sharma A,Chauhan S

    更新日期:2019-05-01 00:00:00

  • Cryofibrinogenemic purpura.

    abstract::A 50-year-old male patient had three episodes of acrally located purpura within 12 years without any other symptoms. The first two episodes which lasted several months coincided with the intake of beta-blockers; the third episode developed after a respiratory infection. A cryofibrinogenemia was found without any evide...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00585916

    authors: Brüngger A,Brülisauer M,Mitsuhashi Y,Schneider BV,Bollinger A,Schnyder UW

    更新日期:1987-01-01 00:00:00

  • Ultrastructural study of pseudo-Kaposi's sarcoma (Bluefarb-Stewart type).

    abstract::An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章

    doi:10.1007/BF00424270

    authors: Fimiani M,Simoni S,Miracco C,De Santi M,Luzi P,Andreassi L

    更新日期:1989-01-01 00:00:00