Abstract：
:The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = 13 profiles). Phospholipid profiles included alkylacylphosphatidylcholine (AAPC), dihydrosphingomyelin (DHSM), diphosphatidylglycerol (cardiolipin), ethanolamine plasmalogen (EPLAS), lysophosphatidylcholine, phosphatidic acid, phosphatidylcholine (PC), phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, sphingomyelin, and uncharacterized phospholipids (U1 and U2, particularly enriched in the epidermis). The computed phospholipid metabolic index (n = 86 indexes) findings can be summarized as follows: a lower content of the en-ol and ether phospholipids in the epidermis relative to the dermis, internal compensation among the component phospholipids so as to maintain the choline functional group ratio, and a greater concentration of hydroxyl-containing functional groups in the epidermis. A membrane index (fmem) value of -0.37 for the epidermis deviated considerably from the value of -0.06 characteristic of living membranes and the dermis. The production of the reduced phosphatides, EPLAS and AAPC, indicates the use of alternative pathways between the two tissues. Relative to the dermis, increased PC in the epidermis coupled with decreased DHSM, EPLAS, and AAPC are factors enabling the epidermis of eyelid tissue to be an effective water barrier.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Greiner JV,Glonek T,Townsend DJ,Hearn SLdoi
10.1007/s004030050308subject
Has Abstractpub_date
1998-06-01 00:00:00pages
298-305issue
6eissn
0340-3696issn
1432-069Xjournal_volume
290pub_type
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505038
更新日期：1996-01-01 00:00:00
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更新日期：1985-01-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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更新日期：2017-09-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1998-09-01 00:00:00
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doi：10.1007/BF00511066
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