TOX expression in cutaneous B-cell lymphomas.


:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also expressed by cutaneous B-cell lymphomas, TOX immunohistochemistry was performed on skin biopsies of 44 patients with primary and secondary cutaneous B-cell proliferations. TOX was expressed not only in the reactive follicle center cells of lymph nodes, tonsils, cutaneous lymphoid hyperplasia, and primary cutaneous marginal zone lymphomas, but also by the neoplastic follicle center cells of 16/17 patients with primary cutaneous follicle center lymphoma (PCFCL) and 7/7 patients with cutaneous manifestations of systemic follicular lymphoma (FL). Notably, TOX showed a very similar expression pattern as BCL6, a marker of germinal center B-cells. In 4/10 patients with a BCL6(+) primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL,LT) and in 2/2 patients with a secondary cutaneous BCL6(+) diffuse large B-cell lymphoma (DLBCL), TOX was expressed by more than 50 % of the neoplastic B-cells. In contrast, in 3/3 BCL6(-) PCDLBCL,LT, TOX was completely negative or weakly expressed by a minor proportion of the neoplastic B-cells. In conclusion, TOX is expressed not only by neoplastic T-cells, but also by both reactive and neoplastic follicle center (germinal center) B-cells and a proportion of BCL6(+) PCDLBCL,LT and secondary cutaneous BCL6(+) DLBCL. The functional significance of TOX expression in reactive and neoplastic B-cells remains to be elucidated.


Arch Dermatol Res


Schrader AM,Jansen PM,Willemze R




Has Abstract


2016-08-01 00:00:00














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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Deshpande M,Papp S,Schaffer L,Pouyani T

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Zesch A,Schaefer H,Stüttgen G

    更新日期:1979-11-01 00:00:00

  • What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review.

    abstract::The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed b...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ayasse MT,Ahmed A,Espinosa ML,Walker CJ,Yousaf M,Thyssen JP,Silverberg JI

    更新日期:2020-11-22 00:00:00

  • Attitudes and practice among dermatologists regarding indoor tanning.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Nahar VK,Wilkerson AH,Mayer JE,Gromley Z,Berry D,Nahar L,Brodell RT

    更新日期:2020-11-01 00:00:00

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Marples RR

    更新日期:1982-01-01 00:00:00

  • Reduction of the number of immunocompetent cells in the acute stage of herpes zoster.

    abstract::Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Baadsgaard O,Lindskov R,Geisler C

    更新日期:1987-01-01 00:00:00

  • Prenatal human skin expresses the antimicrobial peptide RNase 7.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schuster C,Gläser R,Fiala C,Eppel W,Harder J,Schröder JM,Elbe-Bürger A

    更新日期:2013-08-01 00:00:00

  • Opposite regulation of tyrosinase and glutathione peroxidase by intracellular thiols in human melanoma cells.

    abstract::Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Benathan M

    更新日期:1997-05-01 00:00:00

  • [Effect of salicylic acid on the blanching effect of flumethasone pivalate (author's transl)].

    abstract::Test results are reported of the effect of salicylic acid on the vasoconstrictive effect of flumethasone pivalate. In specific, the depigmentation of the skin (identical with increase in lightness of the skin) following topical application of flumethasone pivalate was investigated with the aid of an improved spectroph...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Wienert V,Blazek V

    更新日期:1981-01-01 00:00:00

  • [Skin impedance and phoreographic index in psoriasis. Relationship with action kinetics of three treatments].

    abstract::In a previous study, impedance measurements and phoreographic response were shown to quantify significant differences between involved and non-involved skin in psoriasis. The same techniques were used to objectivate the evolution on skin condition on patients treated with dioxyanthranol, difluprednate, and photochemot...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Cambrai M,Clar EJ,Grosshans E,Altermatt C

    更新日期:1979-03-31 00:00:00

  • Isolation and amino acid sequence of a cystatin-type cysteine proteinase inhibitor from bovine hoof.

    abstract::A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tsushima H,Higashiyama K,Mine H

    更新日期:1996-07-01 00:00:00

  • iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis.

    abstract::The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Cavusoglu N,Delattre C,Donovan M,Bourassa S,Droit A,El Rawadi C,Jourdain R,Bernard D

    更新日期:2016-11-01 00:00:00

  • Gingko biloba extract reduces VEGF and CXCL-8/IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate.

    abstract::In skin inflammation, vascular endothelial growth factor (VEGF) and CXCL-8/IL-8 play an important role and are produced by activated keratinocytes. Extracts from Ginkgo biloba leaves (GBE), widely used in phytotherapy, have been reported to exert antioxidant and anti-inflammatory properties in the skin. We therefore e...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Trompezinski S,Bonneville M,Pernet I,Denis A,Schmitt D,Viac J

    更新日期:2010-04-01 00:00:00

  • A family study of atopic dermatitis. Clinical and genetic characteristics of 188 patients and 2,151 family members.

    abstract::The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Küster W,Petersen M,Christophers E,Goos M,Sterry W

    更新日期:1990-01-01 00:00:00

  • Receptor-linked adenylate cyclase in the membranes of cultured human epidermal keratinocytes.

    abstract::The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Cavey MT,Cavey D,Shroot B,Reichert U,Gazith J

    更新日期:1986-01-01 00:00:00

  • Modulation of type-IV procollagen and laminin production in A431 human squamous epidermoid carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF).

    abstract::The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Panneerselvam M,Sahai A,Salomon DS

    更新日期:1985-01-01 00:00:00

  • The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1.

    abstract::Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Saalbach A,Kraft R,Herrmann K,Haustein UF,Anderegg U

    更新日期:1998-07-01 00:00:00

  • Studies on the role of polymorphonuclear leukocyte granule elastase in Arthus reaction.

    abstract::In the present study, attempts were made to clarify the role of an elastase-like enzyme in Arthus reaction by using rabbit-peritoneal polymorphonuclear leukocytes (PMNs). It was first confirmed that the injection of large amounts of PMNs with antibody can increase tissue damage in reversed Arthus reaction. The five va...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Hamanaka K,Toki N,Tsushima H,Takasugi S

    更新日期:1984-01-01 00:00:00

  • Human malignant melanoma antigenic properties of phenol water extracts.

    abstract::Tumor-associated antigens were demonstrated in phenol water extracts of human malignant melanoma by migration tests with leukocytes from melanoma patients and controls: in 25 out of 60 melanoma patients weak reactivity was observed, usually stimulation of leukocyte migration, while leukocytes from 37 controls were neg...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Suter L,Tilkorn H,Kövary PM

    更新日期:1979-02-23 00:00:00

  • Topical application of a first porphycene dye for photodynamic therapy--penetration studies in human perilesional skin and basal cell carcinoma.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Karrer S,Abels C,Szeimies RM,Bäumler W,Dellian M,Hohenleutner U,Goetz AE,Landthaler M

    更新日期:1997-02-01 00:00:00

  • Anti-tumor effect of PDT using Photofrin in a mouse angiosarcoma model.

    abstract::Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Jin I,Yuji M,Yoshinori N,Makoto K,Mikio M

    更新日期:2008-04-01 00:00:00

  • Detection of fumarate-glutathione adducts in the portal vein blood of rats: evidence for rapid dimethylfumarate metabolism.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Dibbert S,Clement B,Skak-Nielsen T,Mrowietz U,Rostami-Yazdi M

    更新日期:2013-07-01 00:00:00

  • Sunscreen application technique amongst patients with a history of skin cancer.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Dang J,Reserva J,Tung-Hahn E,Vasicek B,Krol C,Adams W,Tung R,Alam M

    更新日期:2020-12-01 00:00:00

  • Evaluation of cutaneous algogenic responses to bradykinin and inhibition by bradykinin analogs.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schneider BK,Morelli JG,Vavrek RJ,Stewart JM,Weston WL

    更新日期:1992-01-01 00:00:00

  • The fibroblastic nature of dermatofibrosarcoma protuberans: morphological investigations in vivo and in vitro.

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    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Schmoeckel C,Albini A,Krieg T,Stets R

    更新日期:1985-01-01 00:00:00

  • PCR analysis for Wolbachia in human and canine Demodex mites.

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    pub_type: 杂志文章


    authors: Borgo SN,Sattler EC,Hogardt M,Adler K,Plewig G

    更新日期:2009-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Cruz MT,Duarte CB,Gonçalo M,Figueiredo A,Carvalho AP,Lopes MC

    更新日期:2002-12-01 00:00:00

  • Plasma oxidation status and antioxidant capacity in psoriatic children.

    abstract::Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidan...

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    pub_type: 杂志文章


    authors: Bacchetti T,Simonetti O,Ricotti F,Offidani A,Ferretti G

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    pub_type: 杂志文章


    authors: Mejia AJ,Matus CE,Pavicic F,Concha M,Ehrenfeld P,Figueroa CD

    更新日期:2015-11-01 00:00:00

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    abstract::Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the P...

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    pub_type: 杂志文章


    authors: Grabacka M,Wieczorek J,Michalczyk-Wetula D,Malinowski M,Wolan N,Wojcik K,Plonka PM

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