Abstract:
:Programmed cell death protein-1 (PD-1) is primarily recognized as an inhibitory receptor involved in the regulation of immunological tolerance. However, recent studies have indicated that PD-1/PD-L1 signaling could also regulate the functions of nonimmune cells and may be involved in regulating hair biology. In this study, we showed in a mouse model of depilation-induced hair cycling that PD-1/PD-L1 are expressed in the murine epidermis and hair follicle (HF) in a hair cycle-dependent manner. During HF morphogenesis, PD-1 expression was strongly decreased during the anagen phase compared with the catagen and telogen phases. PD-L1 expression was enhanced during the catagen phase compared with the anagen and telogen phases. Moreover, direct blockade of PD-L1 not only accelerated hair anagen phase onset but also delayed catagen progression. In conclusion, our findings indicated that PD-1/PD-L1 signaling may act as a negative regulator of hair cycle transition. Anti-PD-1/PD-L1 therapy may thus be a promising strategy for treating anagen-reduced hair loss.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Zhou L,Wen L,Sheng Y,Lu J,Hu R,Wang X,Lu Z,Yang Qdoi
10.1007/s00403-020-02169-9subject
Has Abstractpub_date
2021-01-05 00:00:00eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-020-02169-9pub_type
杂志文章abstract::Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1332-y
更新日期:2013-07-01 00:00:00
abstract::Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognitio...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-017-1790-8
更新日期:2018-03-01 00:00:00
abstract::To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1079-7
更新日期:2011-04-01 00:00:00
abstract::The histological and ultrastructural effects following 3 weeks' topical treatment with two agents (all-trans retinoic acid and a new synthetic retinoid-like substance, CD271) were evaluated on the epidermis and the epithelial wall of the pseudocomedones in rhino mouse skin. The comedolytic effects of these drugs were ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371617
更新日期:1991-01-01 00:00:00
abstract::In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::This study concerns 57 patients who fulfilled histological criteria for the diagnosis allergic vasculitis. For 37 of these patients, biopsy specimen were available from lesional and adjacent non-lesional skin. Histological signs of vasculitis were found at both sites, but in clinically normal skin the perivascular inf...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00406538
更新日期:1980-01-01 00:00:00
abstract::The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404455
更新日期:1980-01-01 00:00:00
abstract::The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
doi:10.1007/s004030050231
更新日期:1997-08-01 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-014-1480-8
更新日期:2014-12-01 00:00:00
abstract::The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00407740
更新日期:1986-01-01 00:00:00
abstract::Studies aimed at understanding the pathology, genetics, and therapeutic response of vitiligo rely on asking a single question about 'physician-diagnosed' vitiligo on surveys to identify subjects for research. However, this type of self-reporting is not sufficient. Our objective was to determine if the patient-administ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1515-1
更新日期:2015-01-01 00:00:00
abstract::A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated. All the 13 patients with keloids revealed in the ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403728
更新日期:1982-01-01 00:00:00
abstract::Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. However, there are no reports concerning the effect of DHEA on the production of Th2-associated lymphokines, IL-4 ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050213
更新日期:1997-06-01 00:00:00
abstract::An aromatic retinoid (Ro 10-9359) in 13-cis retinoic acid (Ro 4-3780) were fed by gastric tube to 170 male adult Syrian hamsters daily for 30 days. A low dose of 1 or 2 mg/kg and a high dose of 20 mg/kg body weight were selected. The effects of both retinoids on the sebaceous glands were assessed planimetrically (15 g...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404284
更新日期:1980-01-01 00:00:00
abstract::Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0747-8
更新日期:2007-06-01 00:00:00
abstract::Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1397-7
更新日期:2014-03-01 00:00:00
abstract::Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin de...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412738
更新日期:1990-01-01 00:00:00
abstract::Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-018-1823-y
更新日期:2018-07-01 00:00:00
abstract::1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00446949
更新日期:1978-12-01 00:00:00
abstract::The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1298-1
更新日期:2013-04-01 00:00:00
abstract::Adult female Wistar rats (n = 48) divided into four groups of 12 were treated orally with 3 mg/kg per day thalidomide, a 0.05% hexachlorobenzene (HCB)--containing diet, with both drugs together and with the vehicles (controls) over periods of 10 and 60 days. The protein and P450 contents and the activities of aminopyr...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00402227
更新日期:1994-01-01 00:00:00
abstract::This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1734-3
更新日期:2017-07-01 00:00:00
abstract::Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-015-1582-y
更新日期:2015-10-01 00:00:00
abstract::Ionotrope glutamate receptors of the N-methyl-D-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0505-0
更新日期:2004-09-01 00:00:00
abstract::No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1882-0
更新日期:2019-01-01 00:00:00
abstract::Atopic dermatitis (AD) is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and quality of life (Qol) in AD patients and (2) to compare the results with data on other chronic skin diseases. To collect data, a non-interventional, cross-sectional nationwide p...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1402-1
更新日期:2014-04-01 00:00:00
abstract::The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1681-4
更新日期:2016-11-01 00:00:00
abstract::Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01982-1
更新日期:2020-03-01 00:00:00
abstract::A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00402624
更新日期:1990-01-01 00:00:00
abstract::Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effect...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01935-8
更新日期:2019-09-01 00:00:00