The PD-1/PD-L1 pathway in murine hair cycle transition: a potential anagen phase regulator.

Abstract:

:Programmed cell death protein-1 (PD-1) is primarily recognized as an inhibitory receptor involved in the regulation of immunological tolerance. However, recent studies have indicated that PD-1/PD-L1 signaling could also regulate the functions of nonimmune cells and may be involved in regulating hair biology. In this study, we showed in a mouse model of depilation-induced hair cycling that PD-1/PD-L1 are expressed in the murine epidermis and hair follicle (HF) in a hair cycle-dependent manner. During HF morphogenesis, PD-1 expression was strongly decreased during the anagen phase compared with the catagen and telogen phases. PD-L1 expression was enhanced during the catagen phase compared with the anagen and telogen phases. Moreover, direct blockade of PD-L1 not only accelerated hair anagen phase onset but also delayed catagen progression. In conclusion, our findings indicated that PD-1/PD-L1 signaling may act as a negative regulator of hair cycle transition. Anti-PD-1/PD-L1 therapy may thus be a promising strategy for treating anagen-reduced hair loss.

journal_name

Arch Dermatol Res

authors

Zhou L,Wen L,Sheng Y,Lu J,Hu R,Wang X,Lu Z,Yang Q

doi

10.1007/s00403-020-02169-9

subject

Has Abstract

pub_date

2021-01-05 00:00:00

eissn

0340-3696

issn

1432-069X

pii

10.1007/s00403-020-02169-9

pub_type

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