The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease.

abstract：:Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased i...

journal_title：Archives of dermatological research

authors： Guarrera M,Parodi A,Cipriani C,Divano C,Rebora A

更新日期：1982-01-01 00:00:00

abstract：:To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...

journal_title：Archives of dermatological research

authors： Rho HS,Ahn SM,Hwang JS

更新日期：2011-04-01 00:00:00

abstract：:Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...

journal_title：Archives of dermatological research

authors： Benathan M

更新日期：1997-05-01 00:00:00

abstract：:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cul...

journal_title：Archives of dermatological research

authors： Baturay NZ,Trombetta LD

更新日期：1988-01-01 00:00:00

abstract：:Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...

journal_title：Archives of dermatological research

authors： Frosch PJ,Schwanitz HJ,Macher E

更新日期：1984-01-01 00:00:00

abstract：:The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...

journal_title：Archives of dermatological research

authors： Landthaler M,Plewig G,Hofmann C,Braun-Falco O

更新日期：1980-01-01 00:00:00

abstract：:Using immunoblot and immunofluorescence analysis, we demonstrated the presence and localization of an immunoreactive form of erythrocyte ankyrin in human epidermal keratinocytes. Immunoblot analysis revealed that both human epidermis and cultured epidermal keratinocytes contained ankyrin-like proteins of molecular mas...

journal_title：Archives of dermatological research

authors： Shimizu T,Takakuwa Y,Koizumi H,Ishibashi T,Ohkawara A

更新日期：1996-01-01 00:00:00

abstract：:Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...

journal_title：Archives of dermatological research

authors： Gruner S,Meffert H,Karasek E,Sönnichsen N

更新日期：1984-01-01 00:00:00

abstract：:Patients with atopic dermatitis (AD) often present with dry skin, and the reduced secretion of sebum may be responsible for the impaired skin barrier function. A sebum check film enables the patient to self-evaluate the skin sebum content. This study compared the sebum check film with a sebumeter. The skin sebum conte...

journal_title：Archives of dermatological research

authors： Furuichi M,Makino T,Matsunaga K,Hamade E,Yokoi H,Shimizu T

更新日期：2010-11-01 00:00:00

abstract：:Forty-one male guinea pigs were treated orally with high doses of aromatic retinoid (Ro 10-9359) 25 mg/kg/day in oleum arachidis for 6 weeks. Twenty-three animals were investigated at the end of this treatment. The remaining 18 animals were investigated after an additional retinoid-free interval of 6 weeks. A control ...

journal_title：Archives of dermatological research

authors： Tsambaos D,Hundeiker M,Mahrle G,Orfanos CE

更新日期：1980-01-01 00:00:00

abstract：:The internal stratum corneum lipid composition was investigated in relation to depth in vivo in healthy human volunteers by extraction following one, three or five strippings. Automated multiple development high-performance thin-layer chromatography (AMD-HPTLC) and gas chromatography (GC) followed by normalized princi...

journal_title：Archives of dermatological research

authors： Bonté F,Saunois A,Pinguet P,Meybeck A

更新日期：1997-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...

journal_title：Archives of dermatological research

authors： Elder JT,Sartor CI,Boman DK,Benrazavi S,Fisher GJ,Pittelkow MR

更新日期：1992-01-01 00:00:00

abstract：:The impact of search strategies on systematic reviews (SR) of atopic dermatitis (AD) is unknown. The purpose of this review was to evaluate search strategies used in SR of AD and their impact on the frequency of manuscripts identified. MEDLINE and EMBASE were searched for SR related to AD. Simulations were performed b...

journal_title：Archives of dermatological research

authors： Ayasse MT,Ahmed A,Espinosa ML,Walker CJ,Yousaf M,Thyssen JP,Silverberg JI

更新日期：2020-11-22 00:00:00

abstract：:Although chemokines are critical elements for the selective attraction and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning T helper (Th) 1 or Th2 chemokines in autoimmune blistering disease (ABD). To determine whether serum levels of chemokines that are preferenti...

journal_title：Archives of dermatological research

authors： Echigo T,Hasegawa M,Shimada Y,Inaoki M,Takehara K,Sato S

更新日期：2006-06-01 00:00:00

abstract：:Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...

journal_title：Archives of dermatological research

authors： Badertscher K,Brönnimann M,Karlen S,Braathen LR,Yawalkar N

更新日期：2005-04-01 00:00:00

abstract：:Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...

journal_title：Archives of dermatological research

authors： Prost O,Nicollier M,Laurent R,Adessi GL

更新日期：1985-01-01 00:00:00

abstract：:HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...

journal_title：Archives of dermatological research

authors： Eggert J,Zachariae H,Svejgaard E,Svejgaard A,Kissmeyer-Nielsen F

更新日期：1982-01-01 00:00:00

abstract：:Test results are reported of the effect of salicylic acid on the vasoconstrictive effect of flumethasone pivalate. In specific, the depigmentation of the skin (identical with increase in lightness of the skin) following topical application of flumethasone pivalate was investigated with the aid of an improved spectroph...

journal_title：Archives of dermatological research

authors： Wienert V,Blazek V

更新日期：1981-01-01 00:00:00

abstract：:In order to improve the characterization of human malignant melanoma cells and their variant gene expression in vitro, a search for specifically regulated genes was performed. Four melanoma cell lines (M5, MEWO, IGR39, SKMEL13) and newly cultured normal human melanocytes were included in a comparative hybridization (d...

journal_title：Archives of dermatological research

authors： Eberle J,Garbe C,Orfanos CE

更新日期：1995-01-01 00:00:00

abstract：:Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...

journal_title：Archives of dermatological research

authors： Ramot Y,Marzani B,Pinto D,Sorbellini E,Rinaldi F

更新日期：2018-07-01 00:00:00

abstract：:Dopamine causes reflex erythema, central blanching, and piloerection depending on the dose and the type of application wheal reaction. Intracutaneous application shows from 1.5 gamma/0.1 ml wheal formation, erythema, piloerection, and blanching combined with increased heat radiation from the skin surface (AGA thermovi...

journal_title：Archives of dermatological research

authors： Stüttgen G,Dreesen R

更新日期：1979-08-01 00:00:00

abstract：:Total osmotic pressure does not differ significantly in suction blister fluid or in serum of healthy persons from blister fluid, suction blister fluid or serum of patients with dermatitis herpetiformis, bullous contact dermatitis and pemphigus vulgaris. The average values reach about 293 mOsmol/kg. This results from d...

journal_title：Archives of dermatological research

authors： Bork K

更新日期：1978-01-01 00:00:00

abstract：:Exposure of hairless mice to the light of a germicidal lamp (254 nm) under conditions which are known to induce epidermal DNA synthesis, cell proliferation, and polyamine metabolism produced a marked increase of polyamine excretion in the urine which lasted for many days. The increase was about the same for free and a...

journal_title：Archives of dermatological research

authors： Seiler N,Richards W,Knödgen B

更新日期：1981-01-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) is known to have beneficial effects on skin. It has been used extensively for the treatment of photodamaged skin. To assess the effects of all-trans retinoic acid on the dermis, specifically its effect on hyaluronate (hyaluronic acid, HA) synthesis and inhibition, tissue-engineered human...

journal_title：Archives of dermatological research

authors： Deshpande M,Papp S,Schaffer L,Pouyani T

更新日期：2014-09-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatmen...

journal_title：Archives of dermatological research

authors： de María Díaz Granados L,Quijano MA,Ramírez PA,Aguirre N,Sanclemente G

更新日期：2018-01-01 00:00:00

abstract：:Medical innovation is crucial to advancing our field, and physicians have the potential to play a leading role due to their daily patient care experiences. The objective of this study was to evaluate the interest in, and barriers to participating in innovation. Two surveys were conducted; the first cross-sectional sur...

journal_title：Archives of dermatological research

authors： Lee KC,Lee I,Okhovat JP,Ko J,Powers JG,Ellis DL,Cheeley J,Garibyan L

更新日期：2020-08-09 00:00:00

abstract：:Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...

journal_title：Archives of dermatological research

authors： Yamamoto T,Saeki Y,Kurasawa M,Kuroda S,Arase S,Sasaki H

更新日期：2008-10-01 00:00:00

abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...

journal_title：Archives of dermatological research

authors： Zesch A,Schaefer H,Stüttgen G

更新日期：1979-11-01 00:00:00

abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...

journal_title：Archives of dermatological research

authors： Nakao H,Yamazaki M,Tsuboi R,Ogawa H

更新日期：2006-09-01 00:00:00

abstract：:Two male patients with longstanding contact sensitivity to chromium were treated with PUVA. One patient, suffering from concomitant photosensitivity, reacted very favorably; his skin lesions cleared and light tolerance increased. This was paralleled by a decrease in the photopatch test reactivity and by the extinction...

journal_title：Archives of dermatological research

authors： Jansén CT,Viander M,Kalimo K,Soppi AM,Soppi E

更新日期：1981-01-01 00:00:00