The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation.

abstract：:The expression and location of the Ki-67 antigen was investigated in 62 basal cell carcinomas (BCC) using immunostaining techniques (PAP and APAAP) on cryostat sections. The tumor samples were classified into three groups according to microarchitecture (nodular, superficial or fibrosing). The Ki-67 growth fraction dis...

journal_title：Archives of dermatological research

authors： Baum HP,Meurer I,Unteregger G

更新日期：1993-01-01 00:00:00

abstract：:The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris. It has been hypothesized that calcipotriol counteracts glucocorticoid-induced skin atrophy which is associated with changes in the extracellular matrix (ECM). To elucidate the combined effects ...

journal_title：Archives of dermatological research

authors： Norsgaard H,Kurdykowski S,Descargues P,Gonzalez T,Marstrand T,Dünstl G,Røpke M

更新日期：2014-10-01 00:00:00

abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...

journal_title：Archives of dermatological research

authors： Aubin F

更新日期：2004-10-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EH) is a genetic disorder of keratins associated with epidermal differentiation. Affected individuals carry gene mutations for conserved sequences of keratins K1 or K10. The structural alterations of tonofilaments in EH seem to be a direct consequence of the keratin gene mutations. EH epi...

journal_title：Archives of dermatological research

authors： Ishida-Yamamoto A,Iizuka H,Manabe M,O'Guin WM,Hohl D,Kartasova T,Kuroki T,Roop DR,Eady RA

更新日期：1995-01-01 00:00:00

abstract：:Human alpha 1(I) and alpha 1(III) procollagen mRNA expression in skin tissue from 15 systemic sclerosis (SSc) patients and from 7 normal control subjects was quantitatively analyzed using in situ hybridization. The grains accumulating in each area, representing procollagen mRNA expression per cell, were counted. To no...

journal_title：Archives of dermatological research

authors： Ohtsuka T,Koibuchi N,Sakai H,Yamakage A,Yamazaki S

更新日期：1999-11-01 00:00:00

abstract：:The effect of theophylline, an inhibitor of phosphodiesterase, on tyrosine (Tyr) transport across cell membrane was studied using cultured B-16 mouse melanoma cells. 1.5 mM Theophylline in culture medium increased Tyr uptake velocity in linear fashion up to 36 h, after which it reached a plateau at which the cells sho...

journal_title：Archives of dermatological research

authors： Saga K,Shimojo T

更新日期：1984-01-01 00:00:00

abstract：:Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...

journal_title：Archives of dermatological research

authors： Morioke S,Takahagi S,Iwamoto K,Shindo H,Mihara S,Kameyoshi Y,Hide M

更新日期：2010-10-01 00:00:00

abstract：:The immigration of circulating T cells into specific tissues is directed by the interaction between adhesion molecules on lymphocyte subpopulations and their ligands on vascular endothelium. Of these, endothelial leucocyte adhesion molecule (ELAM-1), weakly expressed in normal human skin (NHS), seems to be the counter...

journal_title：Archives of dermatological research

authors： Bos JD,de Boer OJ,Tibosch E,Das PK,Pals ST

更新日期：1993-01-01 00:00:00

abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...

journal_title：Archives of dermatological research

authors： Ponec M,Polano MK

更新日期：1979-05-29 00:00:00

abstract：:As the main nitrogen source in Malassezia furfur, tryptophan induces the formation of fluorochromes and pigments, which make the yeast less sensitive to UV light. To detect a chemical UV filter, M. furfur (CBS 1878) was incubated at 30 degrees C for 14 days on a pigment-inducing medium and agar extracts were purified ...

journal_title：Archives of dermatological research

authors： Mayser P,Schäfer U,Krämer HJ,Irlinger B,Steglich W

更新日期：2002-05-01 00:00:00

abstract：:Up to now, bicomponent keratohyalin has only been described for rat epithelium and human intraepidermal sweat ducts and fetal nail organ cells. In normal human interductal epidermis, the keratohyalin appears homogeneous, osmiophilic and stellate in shape. Under pathological conditions, bicomponent keratohyalin has bee...

journal_title：Archives of dermatological research

authors： Kastl I,Anton-Lamprecht I

更新日期：1990-01-01 00:00:00

abstract：:The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone wi...

journal_title：Archives of dermatological research

authors： Bucks DA,Maibach HI,Menczel E,Wester RC

更新日期：1983-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed in some papers, the mechanism of BCC pathogenesis is not fully understood. To the best of our knowledge, VEGF gene polymorphisms have ...

journal_title：Archives of dermatological research

authors： Sobjanek M,Zabłotna M,Lesiak A,Michajłowski I,Szczerkowska-Dobosz A,Sokolowska-Wojdylo M,Nowicki R

更新日期：2014-08-01 00:00:00

abstract：:Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...

journal_title：Archives of dermatological research

authors： Rajnochová Svobodová A,Gabrielová E,Michaelides L,Kosina P,Ryšavá A,Ulrichová J,Zálešák B,Vostálová J

更新日期：2018-07-01 00:00:00

abstract：:Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...

journal_title：Archives of dermatological research

authors： Bezerra MC,Teodoro WR,de Oliveira CC,Velosa AP,Ogido LT,Gauditano G,Parra ER,Capelozzi VL,Yoshinari NH

更新日期：2006-07-01 00:00:00

abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...

journal_title：Archives of dermatological research

authors： Nakao H,Yamazaki M,Tsuboi R,Ogawa H

更新日期：2006-09-01 00:00:00

abstract：:The penetration and permeation of the recombinant protein plasminogen activator inhibitor type 2 (PAI-2) in two formulations, one containing a penetration enhancer, into the psoriatic and uninvolved skin of eight patients with plaque-type psoriasis were investigated. Penetration and permeation of PAI-2 were measured b...

journal_title：Archives of dermatological research

authors： Gould AR,Sharp PJ,Smith DR,Stegink AJ,Chase CJ,Kovacs JC,Penglis S,Chatterton BE,Bunn CL

更新日期：2003-11-01 00:00:00

abstract：:Koebner response was studied in 35 psoriatic patients. Two punch biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after, tape stripping. Alterations in the numbers of CD1+ Langerhans cells, CD4+ and CD8+ T cells and CD11c+ macrophages were mapped mor...

journal_title：Archives of dermatological research

authors： Paukkonen K,Naukkarinen A,Horsmanheimo M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...

journal_title：Archives of dermatological research

authors： Reyna-Rodríguez IL,Chavez-Alvarez S,Garza-Rodríguez V,Franco-Marquez R,Gonzalez-Martinez G,Ocampo-Candiani J,Villarreal-Martinez A

更新日期：2021-01-12 00:00:00

abstract：:The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...

journal_title：Archives of dermatological research

authors： Cavey MT,Cavey D,Shroot B,Reichert U,Gazith J

更新日期：1986-01-01 00:00:00

abstract：:Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the P...

journal_title：Archives of dermatological research

authors： Grabacka M,Wieczorek J,Michalczyk-Wetula D,Malinowski M,Wolan N,Wojcik K,Plonka PM

更新日期：2017-04-01 00:00:00

abstract：:Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex...

journal_title：Archives of dermatological research

authors： Nguyen JK,Austin E,Huang A,Mamalis A,Jagdeo J

更新日期：2020-03-01 00:00:00

abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...

journal_title：Archives of dermatological research

authors： Meguro S,Arai Y,Masukawa Y,Uie K,Tokimitsu I

更新日期：2000-09-01 00:00:00

abstract：:Thrombin has recently been shown not only to exert procoagulant activities, but also to induce mitogenic responses of different cell types involved in wound healing via binding to and cleavage of the thrombin receptor. In order to further explore these aspects of thrombin function, human keratinocytes (HaCaT cell line...

journal_title：Archives of dermatological research

authors： Algermissen B,Sitzmann J,Nürnberg W,Laubscher JC,Henz BM,Bauer F

更新日期：2000-10-01 00:00:00

abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...

journal_title：Archives of dermatological research

authors： Balato A,Raimondo A,Balato N,Ayala F,Lembo S

更新日期：2016-07-01 00:00:00

abstract：:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...

journal_title：Archives of dermatological research

authors： Hachisuka H,Kusuhara M,Higuchi M,Okubo K,Sasai Y

更新日期：1988-01-01 00:00:00

abstract：:Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...

journal_title：Archives of dermatological research

authors： Magina S,Esteves-Pinto C,Moura E,Serrão MP,Moura D,Petrosino S,Di Marzo V,Vieira-Coelho MA

更新日期：2011-04-01 00:00:00

abstract：:In the case of viral acanthomas, the stratum spinosum and granulosum presents ballooned cells which contain all transitional stages from multivesicular bodies (MVB) to keratinosomes. A particularity in condylomata acuminata are the "wagon-wheel" bodies. These structures are typical for the non keratinazed squamous epi...

journal_title：Archives of dermatological research

authors： Heine H,Schaeg G,Nasemann T

更新日期：1978-01-01 00:00:00

abstract：:Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...

journal_title：Archives of dermatological research

authors： Kapp A,Gillitzer R,Kirchner H,Schöpf E

更新日期：1987-01-01 00:00:00

abstract：:No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...

journal_title：Archives of dermatological research

authors： Mizukawa Y,Yamazaki Y,Shiohara T

更新日期：2019-01-01 00:00:00