Abstract：
:Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with atopic dermatitis. The weal and flare reaction was not reduced in the same patients when 1.5 mg of FPL 52758 was applied topically under occlusion for a 24-h period prior to challenge with antigen. The itch and slight pain caused by antigen injection was not experienced in the FPL 52758 pretreated areas. Preliminary clinical results were obtained with the cromone FPL 52757, but due to possible hepatotoxicity this trial was not completed. Another similar cromone without hepatotoxicity was used in a double blind within-patient study. Nine patients with mild to moderate atopic dermatitis were treated with FPL 57787 (5%) ointment and matching placebo ointment. No significant improvement was observed after 4 weeks of treatment with the cromone containing ointment.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Søndergaard J,Kassis V,Knudsen L,Wadskov S,Wanscher B,Weismann Kdoi
10.1007/BF00403843subject
Has Abstractpub_date
1980-01-01 00:00:00pages
223-8issue
3eissn
0340-3696issn
1432-069Xjournal_volume
267pub_type
临床试验,杂志文章abstract：:This study determines if the anatomic region affected percutaneous absorption in the rhesus monkey, an animal model with some relevance to man. Percutaneous absorption of testosterone (13.3 microgram/cm2) from the ventral forearm was 8.8 +/- 2.5%. Absorption from the chest was slightly less (5.3 +/- 0.6%) while that f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403844
更新日期：1980-01-01 00:00:00
abstract：:Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412684
更新日期：1988-01-01 00:00:00
abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418573
更新日期：1979-11-01 00:00:00
abstract：:Human epidermal keratinocytes were grown in culture and the uptake of hematoporphyrin derivatives (HPDs) used in photodynamic therapy was estimated. Keratinocytes loaded with HPDs were irradiated with laser light of 632 nm generated by a helium-neon laser and cell toxicity was determined by the trypan blue exclusion t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00510086
更新日期：1989-01-01 00:00:00
abstract：:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1589-4
更新日期：2015-11-01 00:00:00
abstract：:The effect of theophylline, an inhibitor of phosphodiesterase, on tyrosine (Tyr) transport across cell membrane was studied using cultured B-16 mouse melanoma cells. 1.5 mM Theophylline in culture medium increased Tyr uptake velocity in linear fashion up to 36 h, after which it reached a plateau at which the cells sho...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00414014
更新日期：1984-01-01 00:00:00
abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1654-7
更新日期：2016-08-01 00:00:00
abstract：:Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403786
更新日期：1981-01-01 00:00:00
abstract：:The dependence of epithelial spread on human serum in culture has been studied. Using measured pieces of mouse ear skin epithelial outgrowth about floating explants (epiboly) and from adherent explants was studied. Where compared directly the two systems show similar results. Because of its ease of quantitation, the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417274
更新日期：1979-02-23 00:00:00
abstract：:T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509086
更新日期：1985-01-01 00:00:00
abstract：:Wnt pathway plays an important role in controlling metabolism in cancer cells. It acts as positive modulator for both cell inflammation, through activation of NFκB, and fibrosis, through activation of TGF-β. Therefore, the aim of this study is to investigate the therapeutic effects of blocking Wnt pathway by IWP12 on ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01939-4
更新日期：2019-10-01 00:00:00
abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372034
更新日期：1992-01-01 00:00:00
abstract：:Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050318
更新日期：1998-07-01 00:00:00
abstract：:Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-019-01972-3
更新日期：2020-03-01 00:00:00
abstract：:The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0967-1
更新日期：2009-10-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-013-1381-2
更新日期：2013-09-01 00:00:00
abstract：:HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409265
更新日期：1982-01-01 00:00:00
abstract：:Scleroderma is a chronic fibrosing disease, in which an early inflammatory reaction precedes the fibrotic response. Systematic analysis of the pathways involved in the development of the disease together with information derived from novel animal models have helped to better understand the mechanisms that trigger and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-007-0756-7
更新日期：2007-06-01 00:00:00
abstract：:The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1595-6
更新日期：2015-11-01 00:00:00
abstract：:Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1291-8
更新日期：2012-11-01 00:00:00
abstract：:Langerhans cells appear to be critical for IgE-mediated allergen capture and presentation in human atopic dermatitis. The present study sought to determine whether epidermal (i.e Langerhans cells) and dermal dendritic cells in the skin of dogs with atopic dermatitis are hyperplastic and expressed surface IgE. Frozen s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505260
更新日期：1996-09-01 00:00:00
abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0857-y
更新日期：2008-07-01 00:00:00
abstract：:Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large number of genes involved in immune responses, including cytokines and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0342-y
更新日期：2002-12-01 00:00:00
abstract：:Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1685-0
更新日期：2016-11-01 00:00:00
abstract：:Patients with atopic dermatitis (AD) often present with dry skin, and the reduced secretion of sebum may be responsible for the impaired skin barrier function. A sebum check film enables the patient to self-evaluate the skin sebum content. This study compared the sebum check film with a sebumeter. The skin sebum conte...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1076-x
更新日期：2010-11-01 00:00:00
abstract：:Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-011-1166-4
更新日期：2011-11-01 00:00:00
abstract：:Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372058
更新日期：1991-01-01 00:00:00
abstract：:Biopsy specimens from mixed connective tissue disease (MCTD) and discoid lupus erythematodes (DLE) skin lesions were stained with monoclonal antibodies to differentiation and activation antigens. In addition, the blast cells were studied by combining autoradiography with immunoperoxidase staining. In both disease cond...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412679
更新日期：1988-01-01 00:00:00
abstract：:The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509237
更新日期：1985-01-01 00:00:00
abstract：:The aim of this study was to explore dermatologists' practices and attitudes related to educating and counseling their adolescent patients about indoor tanning. An online survey was carried out with a convenience sample of 100 dermatologists. Findings indicated that the majority of the dermatologists are actively enga...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-02026-4
更新日期：2020-11-01 00:00:00
