Abstract：
:In dermatophytosis, there is exocytosis of polymorphonuclear leukocytes (PMNs) toward the fungus-laden horny layer. To analyze this mechanism, we studied in vitro leukotactic properties of epidermal extracts prepared from lesions of experimental Trichophyton mentagrophytes infection in guinea pigs as well as fungus-derived chemotactic factors. Trichophyton mentagrophytes was found to release low-molecular-weight PMN chemotactic factors with its growth, like other microorganisms. Furthermore, it activated complement via the alternative pathway to produce complement-derived chemotactic factors in vitro. The epidermal extracts prepared from weakly inflammatory lesions of an early stage of T. mentagrophytes infection showed mild PMN chemotactic activity, which, as in those from irritated skin, was mostly due to the presence of low-molecular-weight chemotactic factors. After 8 days of infection, when prominent PMN migration took place together with the development of immune reactivity to fungus antigens, the epidermal extracts revealed strong leukotactic activity that showed a triphasic pattern by Sephadex G-75 chromatography similar to that observed in complement-activated serum. Since we could not demonstrate any deposition of immunoglobulins and complement on the fungal elements present in the horny layer, actual complement activation in vivo seems to occur after interaction of serum with soluble fungal components in the epidermis through both classic and alternative pathways. We think that the transepidermal migration of PMNs in dermatophytosis, together with contact sensitivity to fungal antigens, is responsible for induction of increased epidermopoiesis with resultant desquamation to eliminate the fungus-laden horny layer.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Tagami H,Natsume N,Aoshima T,Inoue F,Suehisa S,Yamada Mdoi
10.1007/BF00409248subject
Has Abstractpub_date
1982-01-01 00:00:00pages
205-17issue
3-4eissn
0340-3696issn
1432-069Xjournal_volume
273pub_type
杂志文章abstract：:The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity. In the total of 582 Czech Caucas...
journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-019-01928-7
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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更新日期：1992-01-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050408
更新日期：1999-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2013-04-01 00:00:00
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更新日期：1991-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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