Abstract：
:Melanoma in situ (MIS) is a form of radial growth phase melanoma in which the proliferation of malignant cells is confined to the epidermis. Histologic features are invaluable in recognition of MIS. Regression occurs when the host's immune system attacks the primary melanocytic tumor cells via tumor infiltrate lymphocytes, resulting in a fibrotic component. Various criteria have been proposed to assess the extent of histologic regression. Some authors define regression based on histologic features of the dermis, which is inappropriate for MIS. Specific dermatoscopic findings of regression in MIS have been reported including peppering, grey-blue areas, white areas, and blue-whitish veils. Many studies assess the impact of histologic regression on invasive melanoma prognosis, but no studies to-date have considered the effect of histologic regression exclusively in patients with MIS. The literature to-date does not suggest evaluation and management should be modified if histologic regression is present in MIS. Studies specifically investigating the effect of histologic regression on MIS prognosis are needed to inform evidence-based practices.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Cartron AM,Aldana PC,Khachemoune Adoi
10.1007/s00403-020-02106-wsubject
Has Abstractpub_date
2020-07-06 00:00:00eissn
0340-3696issn
1432-069Xpii
10.1007/s00403-020-02106-wpub_type
杂志文章,评审abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1487-1
更新日期：2014-10-01 00:00:00
abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02507101
更新日期：1996-06-01 00:00:00
abstract：:Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-014-1525-z
更新日期：2015-03-01 00:00:00
abstract：:Murine mast cell proliferation and maturation are regulated by two distinct cytokines, interleukin-3 (IL-3) and the c-kit ligand, stem cell factor (SCF). In this study using cells of the mouse mast cell line, MC/9, the effects of two immunosuppressants, FK506 and cyclosporin A (CsA), were investigated. Withdrawal of I...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050408
更新日期：1999-05-01 00:00:00
abstract：:Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-018-1823-y
更新日期：2018-07-01 00:00:00
abstract：:We report the clinical features of 62 consecutive patients with lichen planus observed in 18 months. The largest number of cases occurred between 50 and 70 years of age. Thirty-four patients had lichen planus only. In the remainder, lichen planus was associated with chronic liver diseases (16 cases), immune-related di...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice. Metronidazole and tinidazole ointments (1) suppressed the late-phase reaction (LPR) ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0381-4
更新日期：2003-03-01 00:00:00
abstract：:To elucidate the interaction between melanoma and its matrix, we cultured B16 murine melanoma cells on and in type I collagen gel and evaluated specified functions of melanoma cells; tyrosinase activity and melanin-synthesizing capacity. Proliferation of cells cultured in these environments was markedly suppressed com...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371647
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02182-y
更新日期：2021-01-12 00:00:00
abstract：:Sixteen malignant melanoma patients with different levels of tumor progression, two patients with melanoma in situ (Clark 10 two bronchogenic carcinoma patients and nine healthy controls were tested by means of the leukocyte adherence inhibition (LAI) test to assess the function of their cellular mediated immunity. Bl...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403801
更新日期：1980-01-01 00:00:00
abstract：:A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00402624
更新日期：1990-01-01 00:00:00
abstract：:Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412622
更新日期：1987-01-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
abstract：:Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-011-1177-1
更新日期：2012-03-01 00:00:00
abstract：:Secretory component (SC) acts as a transmembrane polymeric immunoglobulin receptor of epithelial cells and is known to bind to polymeric IgA and to contribute to the secretion of secretory IgA (sIgA). We describe a new biological function for free SC (FSC) by which the expression of intercellular adhesion molecule-1 (...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00374074
更新日期：1995-01-01 00:00:00
abstract：:Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1828-6
更新日期：2018-07-01 00:00:00
abstract：:The mechanical properties of the in vivo dermis were measured by means of a torque applied to the skin. The resulting deformation of 2-6 degrees, including the immediate and delayed visco-elastic components, as well as the relaxation were measured, and the raw values corrected for a constant skin thickness. The experi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00406415
更新日期：1980-01-01 00:00:00
abstract：:Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00403-012-1297-2
更新日期：2013-04-01 00:00:00
abstract：:Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cul...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00429985
更新日期：1988-01-01 00:00:00
abstract：:When determined in vitro, the SPF of certain commercial sunscreen products can be lower than the SPF indicated on the label. The study of the composition of this type of product enabled us to note that the majority contained substances reputed to have anti-inflammatory properties. This effect is shown by inhibiting th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1257-x
更新日期：2012-12-01 00:00:00
abstract：:Tympanic (Tty), esophageal (Tes), forehead, and hand skin temperatures, as well as the forehead evaporation rate were recorded in six men (four suffering from rosacea and two healthy controls) before, during, and after 1 h of warm bath (38 degrees-39 degrees C). During the last 30 min of the bath, the subject's face w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00424276
更新日期：1989-01-01 00:00:00
abstract：:Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01976-z
更新日期：2020-01-01 00:00:00
abstract：:Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0938-6
更新日期：2009-04-01 00:00:00
abstract：:Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404352
更新日期：1986-01-01 00:00:00
abstract：:Recently a new thin layer chromatography plate (Whatman LK 6D) became available which is extremely easy to handle and permits highly reproducible qualitative and quantitative analysis. This plate proved to be of great value for the investigation of skin surface lipids. The use of a fatty acid methyl ester as an intern...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412383
更新日期：1979-07-30 00:00:00
abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418572
更新日期：1979-11-01 00:00:00
abstract：:The authors report 2 cases of atypical vitiligo in which they observed 1) "cockade-like" lesions resembling those of "trichrome" vitiligo (from the centre to the periphery, achromic area, hypochromic ring, normal or hyperchromic border), 2) numerous linear achromic lesions corresponding to former excoriations (Koebner...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455391
更新日期：1978-07-28 00:00:00
abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1517-z
更新日期：2014-12-01 00:00:00
abstract：:Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosan-activated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin a produced an increased...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409454
更新日期：1981-01-01 00:00:00
