Abstract：
:Studies aimed at understanding the pathology, genetics, and therapeutic response of vitiligo rely on asking a single question about 'physician-diagnosed' vitiligo on surveys to identify subjects for research. However, this type of self-reporting is not sufficient. Our objective was to determine if the patient-administered Vitiligo Screening Tool (VISTO) is a sensitive and specific instrument for the detection of vitiligo in an adult population. The VISTO consists of eight closed-ended questions to assess whether the survey participant has ever been diagnosed with vitiligo by a healthcare worker and uses characteristic pictures and descriptions to inquire about the subtype and extent of any skin lesions. 159 patients at the Brigham and Women's Hospital dermatology clinic with or without a diagnosis of vitiligo were recruited. A board-certified dermatologist confirmed or excluded the diagnosis of vitiligo in each subject. 147 completed questionnaires were analyzed, 47 cases and 100 controls. The pictorial question showed 97.9% sensitivity and 98% specificity for diagnosis of vitiligo. Answering "yes" to being diagnosed with vitiligo by a dermatologist and choosing one photographic representation of vitiligo showed 95.2% sensitivity and 100% specificity for diagnosis of vitiligo. We conclude that VISTO is a highly sensitive and specific, low-burden, self-administered tool for identifying vitiligo among adult English speakers. We believe this tool will provide a simple, cost-effective way to confirm vitiligo prior to enrollment in clinical trials as well as for gathering large-scale epidemiologic data in remote populations. Future work to refine the VISTO is needed prior to use in genotype-phenotype correlation studies.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Sheth VM,Gunasekera NS,Silwal S,Qureshi AAdoi
10.1007/s00403-014-1515-1subject
Has Abstractpub_date
2015-01-01 00:00:00pages
31-8issue
1eissn
0340-3696issn
1432-069Xjournal_volume
307pub_type
杂志文章abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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abstract：:We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice. Metronidazole and tinidazole ointments (1) suppressed the late-phase reaction (LPR) ...
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doi：10.1007/s00403-002-0381-4
更新日期：2003-03-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0938-6
更新日期：2009-04-01 00:00:00
abstract：:Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this stud...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1828-6
更新日期：2018-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00371739
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pub_type： 杂志文章
doi：10.1007/BF00429984
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0974-2
更新日期：2009-09-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370816
更新日期：1993-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404352
更新日期：1986-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1606-7
更新日期：2016-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1053-4
更新日期：2010-10-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-018-1826-8
更新日期：2018-07-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00446437
更新日期：1978-11-10 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050474
更新日期：2000-04-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-003-0421-8
更新日期：2003-09-01 00:00:00
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-014-1460-z
更新日期：2014-09-01 00:00:00
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doi：10.1007/s00403-017-1734-3
更新日期：2017-07-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00510363
更新日期：1982-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412622
更新日期：1987-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371917
更新日期：1992-01-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：2000-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：2020-03-01 00:00:00
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更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s004030050444
更新日期：1999-09-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417528
更新日期：1986-01-01 00:00:00
abstract：:Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412927
更新日期：1986-01-01 00:00:00
