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Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women.

Abstract：

:Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the association between estimated vitamin D status, derived from a prediction model incorporating lifestyle determinants of serum vitamin D, and self-reported incident AA. We evaluated dietary, supplemental, and total vitamin D intake as additional exposures. Using Cox proportional hazards models, we calculated age-adjusted and multivariate hazard ratios (HR) to evaluate risk of AA. We identified 133 cases of AA over a follow-up of 12 years. The age-adjusted HR between top vs. bottom quartiles for serum vitamin D score was 0.94 (95 % CI 0.60-1.48) and the corresponding multivariate HR was 1.08 (95 % CI 0.68-1.73). There was no significant association between dietary, supplemental, or total vitamin D intake and incident AA. This study does not support a preventive role for vitamin D in the risk of developing AA.

journal_name

Arch Dermatol Res

journal_title

Archives of dermatological research

authors

Thompson JM,Li T,Park MK,Qureshi AA,Cho E

doi

10.1007/s00403-016-1687-y

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

671-676

issue

9

eissn

0340-3696

issn

1432-069X

pii

10.1007/s00403-016-1687-y

journal_volume

308

pub_type

杂志文章

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