Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.

Abstract:

:Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed. Some possible triggers, such as blood antigens and the effect of seasons have also been discussed briefly. Moreover, some protective factors against pemphigus have been reviewed. Considering the molecular mechanism of pemphigus and immune response alteration during this disease, some possible triggers have been suggested and discussed. Although those triggers may be a real threat, more studies are needed to support these hypotheses.

journal_name

Arch Dermatol Res

authors

Tavakolpour S

doi

10.1007/s00403-017-1790-8

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

95-106

issue

2

eissn

0340-3696

issn

1432-069X

pii

10.1007/s00403-017-1790-8

journal_volume

310

pub_type

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