Hydroperoxides in oxidized d-limonene identified as potent contact allergens.

abstract：:The effect of the proteolytic enzyme savinase on human plantar skin in vitro was examined by light and electron microscopy to elucidate the morphological involvement of activated savinase in human epidermis. Light microscopic examination of incubated skin fragments demonstrated that the histological changes produced b...

journal_title：Archives of dermatological research

authors： Imai S

更新日期：1991-01-01 00:00:00

abstract：:Using the sebum-absorbent tape technique, we have disclosed five different patterns of follicular sebum excretion rate (SER). These are the infantile, pubertal, acne, adult and aging patterns, distinguished by different densities of active sebaceous follicles, by distinct levels of follicular SER and by the relative s...

journal_title：Archives of dermatological research

authors： Piérard GE,Piérard-Franchimont C,Lê T,Lapière C

更新日期：1987-01-01 00:00:00

abstract：:Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with...

journal_title：Archives of dermatological research

authors： Furukawa F,Kashihara M,Imamura S,Ohshio G,Hamashima Y

更新日期：1986-01-01 00:00:00

abstract：:Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing glycerol in relatively high amounts, preventing drawing conclusions from direct effects. In this study, acute che...

journal_title：Archives of dermatological research

authors： Atrux-Tallau N,Romagny C,Padois K,Denis A,Haftek M,Falson F,Pirot F,Maibach HI

更新日期：2010-08-01 00:00:00

abstract：:1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...

journal_title：Archives of dermatological research

authors： Herfst MJ,van Rees H

更新日期：1978-12-01 00:00:00

abstract：:Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two pa...

journal_title：Archives of dermatological research

authors： Valentini G,Leonardo G,Moles DA,Apaia MR,Maselli R,Tirri G,Del Guercio R

更新日期：1991-01-01 00:00:00

abstract：:Although chemokines are critical elements for the selective attraction and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning T helper (Th) 1 or Th2 chemokines in autoimmune blistering disease (ABD). To determine whether serum levels of chemokines that are preferenti...

journal_title：Archives of dermatological research

authors： Echigo T,Hasegawa M,Shimada Y,Inaoki M,Takehara K,Sato S

更新日期：2006-06-01 00:00:00

abstract：:We previously showed that the homeodomain protein HOXC13 is involved in the expression control of the early human hair keratin genes hHa5 and hHa2, which contain specific HOXC13 binding sites in their proximal promoters. Hox specificity is generally thought to be enhanced by the interaction with members of the TALE su...

journal_title：Archives of dermatological research

authors： Jave-Suárez LF,Schweizer J

更新日期：2006-02-01 00:00:00

abstract：:Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased i...

journal_title：Archives of dermatological research

authors： Guarrera M,Parodi A,Cipriani C,Divano C,Rebora A

更新日期：1982-01-01 00:00:00

abstract：:Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...

journal_title：Archives of dermatological research

authors： Lu S,Syrjänen SL,Havu VK,Syrjänen S

更新日期：1996-03-01 00:00:00

abstract：:CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced α-smo...

journal_title：Archives of dermatological research

authors： Hu X,Wang H,Liu J,Fang X,Tao K,Wang Y,Li N,Shi J,Wang Y,Ji P,Cai W,Bai X,Zhu X,Han J,Hu D

更新日期：2013-07-01 00:00:00

abstract：:To elucidate the interaction between melanoma and its matrix, we cultured B16 murine melanoma cells on and in type I collagen gel and evaluated specified functions of melanoma cells; tyrosinase activity and melanin-synthesizing capacity. Proliferation of cells cultured in these environments was markedly suppressed com...

journal_title：Archives of dermatological research

authors： Kono T,Furukawa M,Tanii T,Mizuno N,Taniguchi S,Ishii M,Hamada T

更新日期：1990-01-01 00:00:00

abstract：:Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...

journal_title：Archives of dermatological research

authors： Dibbert S,Clement B,Skak-Nielsen T,Mrowietz U,Rostami-Yazdi M

更新日期：2013-07-01 00:00:00

abstract：:Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...

journal_title：Archives of dermatological research

authors： Morioke S,Takahagi S,Iwamoto K,Shindo H,Mihara S,Kameyoshi Y,Hide M

更新日期：2010-10-01 00:00:00

abstract：:In this study, a new procedure for the cultivation of dermal vascular endothelial cells from guinea pig ear lobe was established, and specific binding of [3H]mepyramine to the cultured cell membranes was demonstrated. The vascular endothelial cells were successfully isolated from the dermis of guinea pig ear lobes by ...

journal_title：Archives of dermatological research

authors： Noso N,Hide M,Nakamura K,Yamamoto S

更新日期：1990-01-01 00:00:00

abstract：:T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were...

journal_title：Archives of dermatological research

authors： Ahmed AR

更新日期：1985-01-01 00:00:00

abstract：:Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacu...

journal_title：Archives of dermatological research

authors： Ferrando J,Bombi JA

更新日期：1979-10-01 00:00:00

abstract：:Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...

journal_title：Archives of dermatological research

authors： Kubo M,Zhao Y,Moriguchi T

更新日期：2012-11-01 00:00:00

abstract：:The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...

journal_title：Archives of dermatological research

authors： Cho S,Zheng Z,Cho SB,Choi MJ,Lee KH,Bang D

更新日期：2013-04-01 00:00:00

abstract：:Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with at...

journal_title：Archives of dermatological research

authors： Søndergaard J,Kassis V,Knudsen L,Wadskov S,Wanscher B,Weismann K

更新日期：1980-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases. In this study, we applied the polymerase chain reaction technique to detect 4.977 bp-deleted mtDNA, the most common and abundant deletion of mtDNA, in normal human skin. None of the skin speci...

journal_title：Archives of dermatological research

authors： Yang JH,Lee HC,Lin KJ,Wei YH

更新日期：1994-01-01 00:00:00

abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...

journal_title：Archives of dermatological research

authors： Mitsuyama S,Abe F,Kimura M,Yoshida M,Higuchi T

更新日期：2015-08-01 00:00:00

abstract：:In human skin, epidermal differentiation occurs in two ways: normal differentiation, characterized by keratin 10 expression, and alternative differentiation. Alternative differentiation can be hyperproliferation-associated differentiation (expression of keratin 16) or the reinduction of an embryonic type of differenti...

journal_title：Archives of dermatological research

authors： van Rossum MM,Mommers JM,van de Kerkhof PC,van Erp PE

更新日期：2000-01-01 00:00:00

abstract：:Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-bind...

journal_title：Archives of dermatological research

authors： Faergemann J,Wahlstrand B,Hedner T,Johnsson J,Neubert RH,Nyström L,Maibach H

更新日期：2005-12-01 00:00:00

abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...

journal_title：Archives of dermatological research

authors： Bédane C,Prost C,Thomine E,Intrator L,Joly P,Caux F,Blecker M,Bernard P,Leboutet MJ,Tron F,Lauret P,Bonnetblanc JM,Dubertret L

更新日期：1996-06-01 00:00:00

abstract：:There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients witho...

journal_title：Archives of dermatological research

authors： Rozenblat M,Halaj A,Rozenblat T,Fisher S,Sah M,Dodiuk-Gad RP,Ziv M

更新日期：2019-01-01 00:00:00

abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...

journal_title：Archives of dermatological research

authors： Zhang M,Zhang Y,Ding J,Li X,Zang C,Yin S,Ma J,Wang Y,Cao Y

更新日期：2018-11-01 00:00:00

abstract：:The effect of theophylline, an inhibitor of phosphodiesterase, on tyrosine (Tyr) transport across cell membrane was studied using cultured B-16 mouse melanoma cells. 1.5 mM Theophylline in culture medium increased Tyr uptake velocity in linear fashion up to 36 h, after which it reached a plateau at which the cells sho...

journal_title：Archives of dermatological research

authors： Saga K,Shimojo T

更新日期：1984-01-01 00:00:00

abstract：:Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...

journal_title：Archives of dermatological research

authors： Pedrosa TD,Barros AO,Nogueira JR,Fruet AC,Rodrigues IC,Calcagno DQ,Smith MA,de Souza TP,Barros SB,de Vasconcellos MC,Silva FM,Koolen HH,Maria-Engler SS,Lima ES

更新日期：2016-11-01 00:00:00

abstract：:Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...

journal_title：Archives of dermatological research

authors： Shimizu H,Masunaga T,Kurihara Y,Owaribe K,Wiche G,Pulkkinen L,Uitto J,Nishikawa T

更新日期：1999-10-01 00:00:00