Studies on the immunologic aspects of keloids and hypertrophic scars.

abstract：:Two male patients with longstanding contact sensitivity to chromium were treated with PUVA. One patient, suffering from concomitant photosensitivity, reacted very favorably; his skin lesions cleared and light tolerance increased. This was paralleled by a decrease in the photopatch test reactivity and by the extinction...

journal_title：Archives of dermatological research

authors： Jansén CT,Viander M,Kalimo K,Soppi AM,Soppi E

更新日期：1981-01-01 00:00:00

abstract：:The aim of this investigation was to determine whether volumetric changes occurred in differentiating layers of stratified squamous epithelium. Samples of cheek pouch mucosa from 5 hamsters were obtained, prepared for electron microscopy using carefully controlled methods, and electron micrographs obtained from define...

journal_title：Archives of dermatological research

authors： White FH,Gohari K

更新日期：1982-01-01 00:00:00

abstract：:Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...

journal_title：Archives of dermatological research

authors： Magina S,Esteves-Pinto C,Moura E,Serrão MP,Moura D,Petrosino S,Di Marzo V,Vieira-Coelho MA

更新日期：2011-04-01 00:00:00

abstract：:Acidic polysaccharides (AP) are released from Propionibacterium acnes I and II during growth. Similar antigens are released from two strains of P. avidum, but in a smaller amount. Furthermore, prostaglandin-like substances (PLS) have been isolated from the lipid fraction of P. acnes. The AP antigens give rise to a pre...

journal_title：Archives of dermatological research

authors： Dalen A,Hellgren L,Iversen OJ,Vincent J

更新日期：1980-01-01 00:00:00

abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....

journal_title：Archives of dermatological research

authors： Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LB

更新日期：2006-03-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) is regularly expressed or inducible on all major cutaneous cell populations including Langerhans cells, keratinocytes, endothelial cells and dermal fibroblasts. ICAM-1 is induced in the skin under inflammatory conditions and plays an important role in the activation of T cell...

journal_title：Archives of dermatological research

authors： Chatelain R,Wollenberg A,Martin C,Panhans-Gross A,Bieber T,Degitz K,Heckmann M

更新日期：1998-09-01 00:00:00

abstract：:Localized scleroderma (LoSc) is rare connective tissue disease that manifests with inflammation and fibrosis of the skin. Depending on the LoSc subtype, adjacent structures such as subcutaneous tissue, fascia, muscles, bones may be affected. The hallmark of fibrosis is tissue remodelling with excess deposition of extr...

journal_title：Archives of dermatological research

authors： Wolska-Gawron K,Bartosińska J,Krasowska D

更新日期：2020-07-01 00:00:00

abstract：:Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...

journal_title：Archives of dermatological research

authors： Tawfeek HM,Abou-Taleb DAE,Badary DM,Ibrahim M,Abdellatif AAH

更新日期：2020-03-01 00:00:00

abstract：:Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene thera...

journal_title：Archives of dermatological research

authors： Pfützner W,Joari MR,Foster RA,Vogel JC

更新日期：2006-06-01 00:00:00

abstract：:1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...

journal_title：Archives of dermatological research

authors： Herfst MJ,van Rees H

更新日期：1978-12-01 00:00:00

abstract：:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...

journal_title：Archives of dermatological research

authors： Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina A

更新日期：2015-05-01 00:00:00

abstract：:Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of th...

journal_title：Archives of dermatological research

authors： Hessam S,Sand M,Skrygan M,Bechara FG

更新日期：2017-09-01 00:00:00

abstract：:Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...

journal_title：Archives of dermatological research

authors： Rajan GP,Seifert B,Prümmer O,Joller-Jemelka HI,Burg G,Dummer R

更新日期：1996-08-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...

journal_title：Archives of dermatological research

authors： Moura J,da Silva L,Cruz MT,Carvalho E

更新日期：2013-09-01 00:00:00

abstract：:Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...

journal_title：Archives of dermatological research

authors： Betz RC,Indelman M,Pforr J,Schreiner F,Bauer R,Bergman R,Lentze MJ,Nöthen MM,Cichon S,Sprecher E

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...

journal_title：Archives of dermatological research

authors： Norlén L,Emilson A,Forslind B

更新日期：1997-08-01 00:00:00

abstract：:Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...

journal_title：Archives of dermatological research

authors： Kapp A,Gillitzer R,Kirchner H,Schöpf E

更新日期：1987-01-01 00:00:00

abstract：:In a previous study, impedance measurements and phoreographic response were shown to quantify significant differences between involved and non-involved skin in psoriasis. The same techniques were used to objectivate the evolution on skin condition on patients treated with dioxyanthranol, difluprednate, and photochemot...

journal_title：Archives of dermatological research

authors： Cambrai M,Clar EJ,Grosshans E,Altermatt C

更新日期：1979-03-31 00:00:00

abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...

journal_title：Archives of dermatological research

authors： Nancy AL,Yehuda S

更新日期：2009-01-01 00:00:00

abstract：:Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognitio...

journal_title：Archives of dermatological research

authors： Tavakolpour S

更新日期：2018-03-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...

journal_title：Archives of dermatological research

authors： Elder JT,Sartor CI,Boman DK,Benrazavi S,Fisher GJ,Pittelkow MR

更新日期：1992-01-01 00:00:00

abstract：:The distribution of several markers of keratinocyte differentiation was studied in normal epidermis, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs) using the immunoperoxidase technique on frozen sections of punch biopsy specimens. As markers a panel of chain-specific monoclonal antibodies (MoAbs) di...

journal_title：Archives of dermatological research

authors： Lavrijsen AP,Tieben LM,Ponec M,van der Schroeff JG,van Muijen GN

更新日期：1989-01-01 00:00:00

abstract：:The fetal development of Merkel cells-neuroendocrine cells of the skin - has been a matter of debate for a long time. Recent results have helped to confirm their intraepidermal development in humans. Simple epithelial cytokeratins (CK) nos. 8, 18, 19 and 20 are well established markers at the light microscopic level. ...

journal_title：Archives of dermatological research

authors： Moll I,Zieger W,Schmelz M

更新日期：1996-04-01 00:00:00

abstract：:CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced α-smo...

journal_title：Archives of dermatological research

authors： Hu X,Wang H,Liu J,Fang X,Tao K,Wang Y,Li N,Shi J,Wang Y,Ji P,Cai W,Bai X,Zhu X,Han J,Hu D

更新日期：2013-07-01 00:00:00

abstract：:Murine mast cell proliferation and maturation are regulated by two distinct cytokines, interleukin-3 (IL-3) and the c-kit ligand, stem cell factor (SCF). In this study using cells of the mouse mast cell line, MC/9, the effects of two immunosuppressants, FK506 and cyclosporin A (CsA), were investigated. Withdrawal of I...

journal_title：Archives of dermatological research

authors： Ito F,Toyota N,Sakai H,Takahashi H,Iizuka H

更新日期：1999-05-01 00:00:00

abstract：:A 61-year old woman developed a tumourous nodule in her left leg. Fifteen years ago a similar tumour had been removed in the same localization. Histological examination performed on biopsy material showed bundles of predominantly fusiform tumour cells with nuclear pleomorphism and many mitotic figures. Electron micros...

journal_title：Archives of dermatological research

authors： Seifert HW

更新日期：1978-11-10 00:00:00

abstract：:Exposure to a dry environment leads to depletion of water from the peripheral stratum corneum layers in a process dependent on the relative humidity (RH) and the intrinsic properties of the tissue. We hypothesized that by modulating the water content of the stratum corneum in the surface layers, RH effects the rate of...

journal_title：Archives of dermatological research

authors： Watkinson A,Harding C,Moore A,Coan P

更新日期：2001-09-01 00:00:00

abstract：:Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with insulin resistance (IR), metabolic syndrome and increased cardiovascular risk. Adipokines are biologically active, pleotropic molecules which have been involved in the development of IR and in the pathogenesis of several chronic inflammato...

journal_title：Archives of dermatological research

authors： González-López MA,Vilanova I,Ocejo-Viñals G,Arlegui R,Navarro I,Guiral S,Mata C,Pérez-Paredes MG,Portilla V,Corrales A,González-Vela MC,González-Gay MA,Blanco R,Hernández JL

更新日期：2020-10-01 00:00:00

abstract：:Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determin...

journal_title：Archives of dermatological research

authors： Aberer E,Surtov-Pudar M,Wilfinger D,Deutsch A,Leitinger G,Schaider H

更新日期：2018-03-01 00:00:00

abstract：:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous ...

journal_title：Archives of dermatological research

authors： Salem SA,Abu-Zeid RM,Nada OH

更新日期：2013-03-01 00:00:00