Abstract:
:An antibody was raised to the synthetic pentapeptide pGluHisProGlyLys which, in radioimmunoassay (RIA), could detect the pentapeptide at a level of 10 fmole per tube and exhibited less than 0.5 per cent cross reactivity with a series of related peptides. The RIA was used to demonstrate the presence of C-terminally extended forms of thyrotropin releasing hormone (TRH) in rat hypothalamus. After extraction, the endogenous peptides were resolved by gel exclusion chromatography and TRH-extended peptides were revealed by trypsin digestion to release the pentapeptide. The TRH extended peptides occurred in substantial quantity, approximately 11 pmoles/g, indicating that only partial processing of the gene duplicated prohormone takes place.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Cockle SM,Smyth DGdoi
10.1007/BF01114948subject
Has Abstractpub_date
1986-06-01 00:00:00pages
519-26issue
6eissn
0144-8463issn
1573-4935journal_volume
6pub_type
杂志文章abstract::In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integr...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-007-9036-1
更新日期:2007-06-01 00:00:00
abstract::Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191449
更新日期:2020-01-31 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/b:bire.0000007694.71158.02
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abstract::The concentration of carbonic anhydrase III (CAIII) in male rat liver was found to be 30 times greater than that in the female. Castration of male rats led to marked reduction in liver CAIII concentrations which could be partially restored to control levels by testosterone replacement. Marked developmental and senesce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121959
更新日期:1983-05-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116457
更新日期:1988-04-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
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更新日期:2018-12-11 00:00:00
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1017939725776
更新日期:2001-08-01 00:00:00
abstract::Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181275
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abstract::Our study aimed at exploring the effects of miR-211 on the proliferation and apoptosis of lens epithelial cells in diabetic cataract mice by targetting NAD+-dependent histone deacetylase sirtulin 1 (SIRT1). Healthy male mice were assigned into normal and diabetic cataract groups. Blood glucose, lens turbidity, and apo...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170695
更新日期:2017-07-27 00:00:00
abstract::Peptide sequencing of the complement system regulatory protein, factor H, permitted the synthesis of a mixed sequence oligonucleotide probe. Human liver cDNA libraries were screened and factor H-specific clones selected. No full-length clone was obtained, but the largest available clone, R2a, was found to encode the C...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01124790
更新日期:1987-03-01 00:00:00
abstract::Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191831
更新日期:2019-08-23 00:00:00
abstract::Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...
journal_title:Bioscience reports
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更新日期:2018-10-17 00:00:00
abstract::Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regul...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182196
更新日期:2019-07-10 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a tumor that is commonly found in southern China. NPC has several risk factors, such as infection with the Epstein-Barr virus. However, we know little about the risk factors for eye metastasis (EM) in male patients with NPC. Serum lipids are well recognized as risk factors f...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201082
更新日期:2020-06-26 00:00:00
abstract::The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active subst...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01128815
更新日期:1984-09-01 00:00:00
abstract::The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20171440
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abstract::Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...
journal_title:Bioscience reports
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doi:10.1042/BSR20200799
更新日期:2020-06-26 00:00:00
abstract::The increase in % phosphorylase a associated with muscle contraction is reversed after a few minutes despite continued contractile activity. The present study was undertaken to determine whether adrenaline can activate phosphorylase after deactivation has occurred during prolonged stimulation of contraction. We found ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115118
更新日期:1982-05-01 00:00:00
abstract::We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca(2+)-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The RO...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
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abstract::Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...
journal_title:Bioscience reports
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doi:10.1042/BSR20170772
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journal_title:Bioscience reports
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doi:10.1042/BSR20181283
更新日期:2019-02-08 00:00:00
abstract::Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190108
更新日期:2020-01-31 00:00:00
abstract::The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114933
更新日期:1982-10-01 00:00:00
abstract::Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180005
更新日期:2018-07-02 00:00:00
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journal_title:Bioscience reports
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abstract::Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190100
更新日期:2019-05-02 00:00:00
abstract::Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181320
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160035
更新日期:2016-06-03 00:00:00
abstract::Native bovine parathyroid hormone (bPTH) was found to be readily cleaved with human leukocyte elastase to yield the fragments bPTH(1-41) and bPTH(42-84). These were then isolated by reverse-phase HPLC and characterised by gas-phase sequencing and amino acid analysis. The biological activities of these fragments were a...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122726
更新日期:1987-01-01 00:00:00