Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus.

Abstract:

:Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and whole genome association study (GWAS) data electronically searched were pooled to evaluate the strength of the association with odds ratios (ORs) and 95% confidence intervals (CIs).Results: Seven case-control studies involving 894 cases and 1186 controls were finally included in the meta-analysis. Overall analyses indicated that UII gene rs228648 variant was significantly associated with reduced risk of DM (allele, A vs. G: OR = 0.68, 95%CI = 0.56-0.82; dominant, AA+GA vs. GG: OR = 0.70, 95%CI = 0.53-0.91; homozygote, AA vs. GG: OR = 0.41, 95%CI = 0.28-0.61; recessive, AA vs. GA+GG: OR = 0.36, 95%CI = 0.19-0.71). In subgroup analyses based on ethnicity, the results showed a significant association of rs228648 polymorphism with decreased risk of DM in Chinese population under all five genetic models as well as in non-Chinese population under heterozygote and recessive models. Stratified analyses by specific type of DM also presented a significant association for common diabetes mellitus (CDM) under allele and homozygote as well as gestational diabetes mellitus (GDM) under all genetic models except for homozygote model. However, the synthetic analysis with GWAS data suggested an increased risk of DM with rs228648 effect allele in European population (OR = 1.01, 95%CI = 1.00-1.02).Conclusion: The present meta-analysis preliminarily suggested a potentially opposite role of rs228648 polymorphism associated with DM risk in the Chinese and European population. Further studies are in great request to verify the results.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Zhao Y,Fang S,Que K,Xu G,Zhang H,Qi C,Yang N

doi

10.1042/BSR20181275

subject

Has Abstract

pub_date

2018-12-07 00:00:00

issue

6

eissn

0144-8463

issn

1573-4935

pii

BSR20181275

journal_volume

38

pub_type

杂志文章,meta分析
  • Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1β.

    abstract::Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20171438

    authors: Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

    更新日期:2018-02-12 00:00:00

  • Suppression of microRNA-135b-5p protects against myocardial ischemia/reperfusion injury by activating JAK2/STAT3 signaling pathway in mice during sevoflurane anesthesia.

    abstract::The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20170186

    authors: Xie XJ,Fan DM,Xi K,Chen YW,Qi PW,Li QH,Fang L,Ma LG

    更新日期:2017-06-27 00:00:00

  • Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.

    abstract::Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20150314

    authors: Wang W,Shi Y,Li J,Cui W,Yang B

    更新日期:2016-04-05 00:00:00

  • Reduced lipogenesis in cafeteria-fed rats exhibiting diet-induced thermogenesis.

    abstract::Fatty-acid synthesis has been measured in vivo with 3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01122453

    authors: Rothwell NJ,Stock MJ,Trayhurn P

    更新日期:1983-03-01 00:00:00

  • The relationship between secretion and intracellular free calcium in bovine adrenal chromaffin cells.

    abstract::The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01121918

    authors: Burgoyne RD

    更新日期:1984-07-01 00:00:00

  • Down-regulation of microRNA-138 improves immunologic function via negatively targeting p53 by regulating liver macrophage in mice with acute liver failure.

    abstract::MicroRNAs (miRNAs) have been frequently identified as key mediators in almost all developmental and pathological processes, including those in the liver. The present study was conducted with aims of investigating the role of microRNA-138 (miR-138) in acute liver failure (ALF) via a mechanism involving p53 and liver ma...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20190763

    authors: Wang YQ,Lan YY,Guo YC,Yuan QW,Liu P

    更新日期:2019-07-18 00:00:00

  • Association between dectin-1 gene single nucleotide polymorphisms and fungal infection: a systemic review and meta-analysis.

    abstract:OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析

    doi:10.1042/BSR20191519

    authors: Zhou P,Xie Y,Yan Z,Liu X,Hua H

    更新日期:2019-11-29 00:00:00

  • The prognostic roles of circulating ALDH1+ tumor cell in the patients with non-small cell lung cancer.

    abstract::Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20180914

    authors: Tian S,Xing YN,Xia P

    更新日期:2018-10-31 00:00:00

  • Solvation properties of ubiquinone-10 in solvents of different polarity.

    abstract::The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01117101

    authors: Ondarroa M,Sharma SK,Quinn PJ

    更新日期:1986-09-01 00:00:00

  • Keratitis.

    abstract::Corneal inflammation or keratitis is a significant cause of ocular morbidity around the world. Fortunately, the majority of the cases are successfully managed with medical therapy, but the failure of therapy does occur, leading to devastating consequences of either losing the vision or the eye. This review attempts to...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审

    doi:10.1023/a:1017939725776

    authors: Sharma S

    更新日期:2001-08-01 00:00:00

  • Myelin basic protein inhibits the calcium response to phytohaemagglutinin in human lymphocytes.

    abstract::Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01116851

    authors: Bellini T,Degani D,Matteuzzi M,Dallocchio F

    更新日期:1990-02-01 00:00:00

  • Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway.

    abstract::Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20193431

    authors: Zhao H,Liu M,Liu H,Suo R,Lu C

    更新日期:2020-03-27 00:00:00

  • Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment.

    abstract:BACKGROUND:Breast cancer (BC) is the most common malignancy among females worldwide. The tumor microenvironment usually prevents effective lymphocyte activation and infiltration, and suppresses infiltrating effector cells, leading to a failure of the host to reject the tumor. CC chemokines play a significant role in in...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20202042

    authors: Chen B,Zhang S,Li Q,Wu S,He H,Huang J

    更新日期:2020-11-27 00:00:00

  • IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway.

    abstract:OBJECTIVE:To observe the restraining effect of IL-38 on inflammatory response in collagen-induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α signaling pathway. METHODS:40 SD rats were randomly divided into Control group, CIA group, CLL group and CLH group, with 10 rats in each group;...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20182431

    authors: Pei B,Chen K,Zhou S,Min D,Xiao W

    更新日期:2020-05-29 00:00:00

  • siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo.

    abstract::NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20140124

    authors: Hu P,Chen X,Sun J,Bie P,Zhang LD

    更新日期:2015-01-14 00:00:00

  • LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population.

    abstract::Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20171667

    authors: Zhang Z,Chang Y,Jia W,Zhang J,Zhang R,Zhu J,Yang T,Xia H,Zou Y,He J

    更新日期:2018-02-08 00:00:00

  • Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A).

    abstract::Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01145960

    authors: Malhotra R,Haurum J,Thiel S,Jensenius JC,Sim RB

    更新日期:1993-04-01 00:00:00

  • The first EGF domain of coagulation factor IX attenuates cell adhesion and induces apoptosis.

    abstract::Coagulation factor IX (FIX) is an essential plasma protein for blood coagulation. The first epidermal growth factor (EGF) motif of FIX (EGF-F9) has been reported to attenuate cell adhesion to the extracellular matrix (ECM). The purpose of the present study was to determine the effects of this motif on cell adhesion an...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20160098

    authors: Ishikawa T,Kitano H,Mamiya A,Kokubun S,Hidai C

    更新日期:2016-06-03 00:00:00

  • Glucose-induced reduction of the sodium content in beta-cell-rich pancreatic islets.

    abstract::The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resu...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01114973

    authors: Wesslén N,Bergsten P,Hellman B

    更新日期:1986-11-01 00:00:00

  • A possible adenine nucleotide storage form in normal and ischaemic rat heart.

    abstract::Perfusion of Langendorff rat hearts with [14C]adenosine yields an acid-insoluble, radioactive product whose concentration falls during ischaemia. The properties of the substance show that it is a polyribonucleotide. It is suggested that it may be mitochondrial poly A acting as a storage form of adenine nucleotides. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01117435

    authors: Fitt PS,Korecky B,Sharma N

    更新日期:1985-01-01 00:00:00

  • Localized energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22.

    abstract::The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1007/BF01114933

    authors: Hitchens GD,Kell DB

    更新日期:1982-10-01 00:00:00

  • Nobel Lecture. Yeast and cancer.

    abstract::The discovery of genes that control cell division in yeast, and their relation to cancer, is reviewed. ...

    journal_title:Bioscience reports

    pub_type: 传,历史文章

    doi:10.1023/a:1020918107706

    authors: Hartwell LH

    更新日期:2002-06-01 00:00:00

  • KRT18 is correlated with the malignant status and acts as an oncogene in colorectal cancer.

    abstract::Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20190884

    authors: Zhang J,Hu S,Li Y

    更新日期:2019-08-13 00:00:00

  • Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway.

    abstract::The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20171056

    authors: Wang XJ,Xiao JJ,Liu L,Jiao HC,Lin H

    更新日期:2017-11-17 00:00:00

  • Whole genome survey analysis and microsatellite motif identification of Sebastiscus marmoratus.

    abstract::The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20192252

    authors: Xu SY,Song N,Xiao SJ,Gao TX

    更新日期:2020-02-28 00:00:00

  • Evaluating mitochondrial membrane potential in cells.

    abstract::Permeant cationic fluorescent probes are widely employed to monitor mitochondrial transmembrane potential and its changes. The application of such potential-dependent probes in conjunction with both fluorescence microscopy and fluorescence spectroscopy allows the monitoring of mitochondrial membrane potential in indiv...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审

    doi:10.1007/s10540-007-9033-4

    authors: Solaini G,Sgarbi G,Lenaz G,Baracca A

    更新日期:2007-06-01 00:00:00

  • A promising growth promoting Meyerozyma caribbica from Solanum xanthocarpum alleviated stress in maize plants.

    abstract::Fungal endophytes are known to secrete a large array of secondary metabolites (phenols, flavonoids, indole acetic acid (IAA) etc.) that facilitate crops under stress conditions. Considering this, a potent plant growth promoting endophyte (SXSp1) from the spines and leaves of Solanum xanthocarpum L. has been isolated. ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20190290

    authors: Jan FG,Hamayun M,Hussain A,Iqbal A,Jan G,Khan SA,Khan H,Lee IJ

    更新日期:2019-10-30 00:00:00

  • Identification of a Novel Mutation in the ABCA4 Gene in a Chinese Family with Retinitis Pigmentosa Using Exome Sequencing.

    abstract::Retinitis pigmentosa (RP) is a group of hereditary, degenerative retinal disorders characterized by progressive retinal dysfunction, outer retina cell loss, and retinal tissue atrophy. It eventually leads to tunnel vision and legal, or total blindness. Here we aimed to reveal the causal gene and mutation contributing ...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1042/BSR20171300

    authors: Huang X,Yuan L,Xu H,Zheng W,Cao Y,Yi J,Guo Y,Yang Z,Li Y,Deng H

    更新日期:2018-04-27 00:00:00

  • Infantile mitochondrial disorders.

    abstract::Mitochondrial disorders encompass any medical specialty and affect patients at any age. Likewise, the spectrum of clinical and genetic signatures of these disorders is ample, making a precise diagnosis difficult. We will report some of the major clinical phenotypes observed in infancy, their underlining molecular feat...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审

    doi:10.1007/s10540-007-9039-y

    authors: Carrozzo R,Piemonte F,Tessa A,Lucioli S,Rizza T,Meschini MC,Fattori F,Santorelli FM

    更新日期:2007-06-01 00:00:00

  • Effects of D-glucose on chemokinesis and resting production of reactive oxygen species in neutrophil granulocytes of lean or obese-hyperglycemic mouse.

    abstract::The response to D-glucose (0-21 mM) was studied in neutrophil granulocytes from obese, hyperglycemic and hyperinsulinemic Umeå ob/ob mice and their lean, littermate controls in order to further elucidate the effects of in vivo and in vitro hyperglycemia on neutrophil function. Neutrophil random locomotion on glass and...

    journal_title:Bioscience reports

    pub_type: 杂志文章

    doi:10.1023/a:1027399921351

    authors: Oldenborg PA,Sehlin J

    更新日期:1997-10-01 00:00:00