Cryptic I antigen activity and Mycoplasma pneumoniae-receptor activity associated with sialoglycoprotein GP-2 of bovine erythrocyte membranes.

Abstract:

:The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active substance thus far tested. Since this glycoprotein is hydrophobic and can be readily re-incorporated into cell membranes, it should be useful in future studies of the mechanism of production of autoantibodies to the I antigen which commonly arise following human infection with M. pneumoniae.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Feizi T,Gooi HC,Loomes LM,Suzuki Y,Suzuki T,Matsumoto M

doi

10.1007/BF01128815

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

743-9

issue

9

eissn

0144-8463

issn

1573-4935

journal_volume

4

pub_type

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